Abstract:
:Late-acquired stent malapposition (LASM) is a common finding after sirolimus-eluting stent (SES) implantation and may be the cause for late stent thrombosis. Inflammation may play a pivotal role in LASM just as it plays in stent restenosis. We have therefore investigated seven polymorphisms involved in inflammatory processes, related in previous reports to restenosis, on the risk of LASM in SES patients. Patients with ST-elevation myocardial infarction who underwent SES implantation and had intravascular ultrasonography (IVUS) data available for both immediate post-intervention and 9-month follow-up were included in the present study. In total, 104 patients from the MISSION! Intervention Study were genotyped for the caspase-1 5352 G/A, eotaxin 1382 A/G, CD14 260 A/G, colony stimulating factor 2 1943 C/T, IL10 -1117 C/T, IL10 4251 C/T, and the tumor necrosis factor alpha 1211 C/T polymorphisms. LASM occurred in 26/104 (25%) of patients. We found a significantly higher risk for LASM in patients carrying the caspase-1 (CASP1) 5352 A allele (RR = 2.32; 95% CI 1.22-4.42). In addition, mean neointimal growth was significantly lower in patients carrying this LASM risk allele (1.6 vs. 4.1%, p = 0.014). The other six polymorphisms related to inflammation were not significantly related to the risk of LASM. In conclusion, carriers of the 5352 A allele in the caspase-1 gene are at increased risk of developing LASM after SES implantation. If this is confirmed in larger studies, then screening for this polymorphism in patients undergoing percutaneous coronary interventions could eventually help cardiologists to better select between commercially available stents.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Bergheanu SC,Pons D,van der Hoeven BL,Liem SS,Siegerink B,Schalij MJ,van der Bom JG,Jukema JWdoi
10.1007/s00380-010-0046-8subject
Has Abstractpub_date
2011-05-01 00:00:00pages
235-41issue
3eissn
0910-8327issn
1615-2573journal_volume
26pub_type
杂志文章,随机对照试验abstract::Hypertrophic cardiomyopathy (HCM) with severe diastolic dysfunction is a major cause of heart failure and sudden cardiac death (SCD) associated with lethal arrhythmia. Although various risk factors for cardiac events have been reported in HCM patients, previous studies have reported that some HCM patients exhibit eith...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01440-y
更新日期:2019-12-01 00:00:00
abstract::Flow-mediated dilation (FMD) is a widely used tool to investigate endothelial function. However, FMD assessment may cause mechanical damage to the arterial endothelium. In this study we investigated the effect of FMD assessment on endothelial function. We studied 20 healthy subjects (26 ± 6 years; 12 males). FMD was a...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-010-0087-z
更新日期:2011-09-01 00:00:00
abstract::Studies have demonstrated that thyroid hormone (T3) can precondition the heart against ischaemic injury and improve post-ischaemic recovery. This study investigated whether the AT2 receptor (AT2R) is involved in cardioprotection and the potential molecular mechanism responsible for this effect. Hyperthyroidism was ind...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1101-5
更新日期:2018-06-01 00:00:00
abstract::Females have increase in-hospital mortality and poorer outcomes following coronary artery bypass grafting (CABG). Biological differences in the reactivity of the graft conduits to circulating catecholamine may contribute to this sex difference. This study examined sex differences in the vasoconstrictor responses of in...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01508-9
更新日期:2020-03-01 00:00:00
abstract::In the present study, we investigated whether gallic acid (GA) can induce death in cultured vascular smooth muscle cells (VSMCs), and whether production of the hydroxyl radical (.OH) is involved in the process of GA action. GA killed cultured VSMCs from rat aorta, in a dosc- and time-dependent manner. Cytoplasmic shri...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800070038
更新日期:2000-01-01 00:00:00
abstract::Subclavian artery stenosis can cause a flow reversal-so-called steal-not only in the ipsilateral vertebral artery, but also in the internal mammary artery in patients with a history of coronary-artery bypass grafting. Subclavian artery stenosis is also associated with peripheral artery disease elsewhere. We report a n...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0821-2
更新日期:2016-11-01 00:00:00
abstract::Activation of mineralocorticoid receptor antagonists (MRAs) is cardioprotective; however, this property is lost upon blockade or inactivation of adenosine (ADO) receptor A2b. In this study, we investigated whether the effects of MRAs are mediated by an interaction between cardioprotective ADO receptors A1 and A3. Spir...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01542-7
更新日期:2020-05-01 00:00:00
abstract::Coronary artery spasm is involved in the pathogenesis of various cardiac disorders. We investigated patients with a history of syncope who underwent elective coronary angiography. We retrospectively analyzed 5781 consecutive patients who had diagnostic or follow-up angiography during a 26-year period. During this peri...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1046-8
更新日期:2018-02-01 00:00:00
abstract::We report herein an adult case of anomalous origin of the left coronary artery from the pulmonary artery (Bland-White-Garland syndrome; BWG syndrome). The patient had chest discomfort during exercise and signs of mitral regurgitation. We diagnosed him as having BWG syndrome by angiography, and performed surgical treat...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01746067
更新日期:1994-01-01 00:00:00
abstract::We investigated the incidence of post-intubation hypotension (PIH) in hemodynamically stable patients with STEMI requiring rapid sequences intubation (RSI) and medicated with ketamine or midazolam as induction agent. STEMI patients admitted between 1st January 2009 and 1st January 2017 who did not receive any type of ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1049-5
更新日期:2018-03-01 00:00:00
abstract::Atrial fibrillation (AF) is a complex disease with multiple inter-relating causes culminating in rapid atrial activation and atrial structural remodeling. The contribution of endoplasmic reticulum and mitochondria stress to AF has been highlighted. As the class III antiarrhythmic agent, ibutilide are widely used to AF...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0891-1
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:An increase in epicardial adipose tissue (EAT) volume is associated with the development of atrial fibrillation (AF) and coronary artery disease (CAD), but little is known about differences in its distribution. METHODS AND RESULTS:We included 50 patients with paroxysmal AF (PAF), 50 patients with CAD, and 5...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01575-3
更新日期:2020-08-01 00:00:00
abstract::Balneotherapy has been shown to reduce systemic blood pressure in healthy volunteers. Hyperthermia might ameliorate the inflammatory status in heart failure through improving cardiac function. The purpose of this study was to examine the beneficial effects of balneotherapy in patients with chronic heart failure (CHF)....
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-011-0220-7
更新日期:2013-03-01 00:00:00
abstract::Transcatheter MitraClip repair is a new tool for the management of severe mitral regurgitation in patients at very high risk for conventional surgery. Aim of our study was reporting one-year clinical outcomes in candidates to MitraClip procedures, divided into three groups according to the cardiovascular medicine hear...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0772-z
更新日期:2016-10-01 00:00:00
abstract::Eicosapentaenoic acid (EPA), a member of the omega-3 polyunsaturated fatty acid family, prevents cardiovascular disease. C-reactive protein (CRP) is a marker of inflammation, which promotes atherosclerosis. The aim of this study was to investigate the relationship among EPA, CRP, and the prevalence of peripheral arter...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0384-4
更新日期:2014-07-01 00:00:00
abstract::Contrast echocardiography with sonicated radiographic contrast agents has been used for the qualitative and quantitative determination of myocardial blood flow. One major problem has been the size of the microbubbles since only bubbles smaller than 8 microns are expected to pass the capillary bed and larger bubbles ma...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744500
更新日期:1995-01-01 00:00:00
abstract::The resting full-cycle ratio (RFR), a novel resting index, is well correlated with and shows good diagnostic accuracy to the fractional flow reserve (FFR). However, discordance results between the RFR and FFR have been observed to occur in about 20% of cases. This study aimed to clarify the prevalence and factors of d...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01763-1
更新日期:2021-01-05 00:00:00
abstract::High levels of serum phosphate are associated with calcification of human smooth muscle cells (HSMCs). We investigated whether inhibition of protein kinase A (PKA) and mitogen-activated protein kinase (MAPK) signals [p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK)] can reduce inorga...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0427-x
更新日期:2014-09-01 00:00:00
abstract::Compared to conscious sedation (CS), the use of general anesthesia (GA) in pulmonary vein isolation (PVI) is associated with a lower recurrence rate of atrial fibrillation (AF). GA may improve catheter stability and mapping system accuracy compared to CS, but its influence on contact force (CF) parameters during ipsil...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0961-z
更新日期:2017-08-01 00:00:00
abstract::Insulin resistance (IR) is now considered to be a risk factor for coronary arterial atherosclerosis and is likely to be involved in a limited endothelium-dependent vasodilatory function in peripheral circulation. We investigated whether IR impairs endothelial vasodilator function in the noninfarcted coronary artery. I...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-007-1002-0
更新日期:2008-01-01 00:00:00
abstract::Coexistence of hypertension and diabetes mellitus (DM) increases the risk of cardiovascular disease. However, factors associated with future development of DM have not been well elucidated in patients already having essential hypertension. This study prospectively included 168 patients (mean age 41 +/- 7 years, 112 me...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-009-1218-2
更新日期:2010-09-01 00:00:00
abstract::A cardiac angiotensin II-generating system is thought to be involved in cardiac fibrosis. Both angiotensin-converting enzyme (ACE) and human chymase can convert angiotensin I to angiotensin II. However, the relative contributions of these two enzymatic pathways to angiotensin II generation in vivo remain to be clarifi...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Prolongation of the pulmonary artery potentials (PAPs) in response to short coupling intervals was related to polymorphic QRS configurations during the ventricular tachycardia originating above the pulmonary valve (PA-VT). This prospective study was aimed to investigate the mechanisms of polymorphic changes during the...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1209-2
更新日期:2019-01-01 00:00:00
abstract::Wave intensity (WI) is a new hemodynamic index, which is defined as (dP/dt)(dU/dt) at any site of the circulation, where dP/dt and dU/dt are the time derivatives of blood pressure and velocity, respectively. Arterial WI in normal subjects has two positive sharp peaks. The first peak occurs during early systole when a ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF03257237
更新日期:1999-01-01 00:00:00
abstract::To assess left ventricular diastolic properties in response to dynamic exercise, mitral inflow velocity integrals were measured by pulsed-wave Doppler echocardiography in ten patients with myocardial infarction and in ten normal subjects, and simultaneous left ventricular pressure was obtained with micromanometry in t...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Gradient-echo T2-star (T2*)-weighted magnetic resonance imaging (MRI) is a sensitive method to detect cerebral microbleeds (CMBs). The presence of CMBs was reported to be a marker of future cardiovascular mortality and is associated with various cardiovascular risk factors, use of antithrombotic drugs, and cognitive d...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01503-0
更新日期:2020-03-01 00:00:00
abstract::Adenosine constricted 37 of 58 isolated and perfused monkey coronary arteries, whereas it dilated dog coronary arteries in all cases. The vasoconstriction induced by 0.1-10 micrograms (0.37-37.4 nmol) of adenosine was examined, since adenosine in large doses produced tachyphylaxis. The adenosine-induced vasoconstricti...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058320
更新日期:1990-01-01 00:00:00
abstract::Lamotrigine has been used for patients with epilepsy and/or bipolar disorder, overdose of which induced the hypotension, elevation of the atrial pacing threshold, cardiac conduction delay, wide complex tachycardia, cardiac arrest and Brugada-like electrocardiographic pattern. To clarify how lamotrigine induces those c...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01716-8
更新日期:2020-11-02 00:00:00
abstract::Chronic inflammation has received a great deal of attention due to the role it plays in cardiovascular disease (CVD). The cardio-ankle vascular index (CAVI) has recently been developed to evaluate arterial stiffness. This index is independent of blood pressure at the time that it is measured, making it a better measur...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0182-9
更新日期:2012-09-01 00:00:00
abstract::Ventricular arrhythmias play a critical role in chronic heart failure (CHF) and are associated with adverse clinical outcomes. Sleep-disordered breathing (SDB) is associated with arrhythmias and/or a poor prognosis in CHF. Adaptive servo-ventilation (ASV) is a ventilatory support system designed to normalize ventilati...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0394-2
更新日期:2014-07-01 00:00:00