Increased prevalence of cerebral microbleeds in patients with low left ventricular systolic function.

Abstract:

:Gradient-echo T2-star (T2*)-weighted magnetic resonance imaging (MRI) is a sensitive method to detect cerebral microbleeds (CMBs). The presence of CMBs was reported to be a marker of future cardiovascular mortality and is associated with various cardiovascular risk factors, use of antithrombotic drugs, and cognitive dysfunction. However, the relationship between cardiac function and CMBs remains unclear. We investigated the association between cardiac function and presence of CMBs in patients with cardiovascular diseases. This single-center retrospective study included a total of 424 participants (mean age 70 ± 12 years; men 286 (67%); mean left ventricular ejection fraction (LVEF) 61% ± 12%] who underwent echocardiography and brain T2*-weighted MRI within 1 month without neurologic abnormality. CMBs were found in 118 (28%) patients. There was no significant relationship between CMBs and anticoagulant or antiplatelet therapy. LVEF was significantly lower in patients with CMBs than in those without CMBs (59% ± 13% vs. 62% ± 11%, P < 0.05). On multivariate logistic analysis, lower LVEF [odds ratio (OR) 0.98, 95% confidence interval (CI) 0.96-1.00; P < 0.05] and age (OR 1.02, 95% CI 1.00-1.05; P < 0.05) were significantly associated with CMBs. The presence of CMBs was frequently observed in the patients with cardiovascular disease and was significantly associated with age and LVEF.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Watanabe T,Kanzaki Y,Yamauchi Y,Ito T,Nishida Y,Yamamura K,Komori T,Sohmiya K,Hoshiga M

doi

10.1007/s00380-019-01503-0

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

384-390

issue

3

eissn

0910-8327

issn

1615-2573

pii

10.1007/s00380-019-01503-0

journal_volume

35

pub_type

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