当前位置： SCI文献检索 > HEART AND VESSELS期刊下所有文献 > Insulin resistance functionally limits endothelium-dependent coronary vasodilation in nondiabetic patients.

Insulin resistance functionally limits endothelium-dependent coronary vasodilation in nondiabetic patients.

Abstract：

:Insulin resistance (IR) is now considered to be a risk factor for coronary arterial atherosclerosis and is likely to be involved in a limited endothelium-dependent vasodilatory function in peripheral circulation. We investigated whether IR impairs endothelial vasodilator function in the noninfarcted coronary artery. In 14 nondiabetic patients (10 males, 66 +/- 6 years) who were selected from 214 patients underwent IR evaluation by glucose clamp, a Doppler flow wire was used to measure coronary flow changes (percent volume flow index, %VFI) during intracoronary administration of papaverin (10 mg) and stepwise administration of acetylcholine (Ach; 1, 3, 10 microg/ml per minute) into the non-infarcted left circumflex coronary artery. Insulin resistance was comparatively evaluated by an euglycemic hyperinsulinemic glucose clamp (M value, mg/m(2) per minute) or by a 75g-oral glucose tolerance test (120-min immunoreactive insulin; 120' IRI, pmol/l). Eight patients (57%) were defined as having IR on the basis of results obtained by both the glucose clamp method (M values <167 mg/m(2) per minute) and 120' IRI (>384 pmol/l). There was no difference between papaverin-induced %VFI increases in IR and non-IR subjects (328% +/- 43% vs. 361% +/- 87%). However, IR subjects showed significantly lower Ach-induced %VFI increases in a dose-dependent manner (P < 0.05), especially when low (1 microg/ml per minute) and moderate (3 microg/ml per minute) doses of Ach were used (165% +/- 18% or 248% +/- 29% in non-IR subjects vs. 130% +/- 20% or 183% +/- 41% in IR subjects, P < 0.001, respectively). Moreover, %VFI increase at a low dose of Ach infusion significantly correlated with M values or 120' IRI ([%VFI Ach 1 microg] = 85.9 + 0.35 [M values], r = 0.58, P = 0.038; [%VFI Ach 1 microg] = 176.8 - 0.47.[120' IRI], r = -0.57, P = 0.035). Insulin resistance limits endothelium-dependent coronary vasodilation in association with the severity of IR in non-diabetic patients.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Fujii N,Tsuchihashi K,Sasao H,Eguchi M,Miurakami H,Hase M,Higashiura K,Yuda S,Hashimoto A,Miura T,Ura N,Shimamoto K

doi

10.1007/s00380-007-1002-0

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

9-15

issue

eissn

0910-8327

issn

1615-2573

journal_volume

pub_type

杂志文章

在线工具

Insulin resistance functionally limits endothelium-dependent coronary vasodilation in nondiabetic patients.