Abstract:
:While recent guidelines for the treatment of acute heart failure syndromes (AHFS) recommend pharmacotherapy with vasodilators in patients without excessively low blood pressure (BP), few reports have compared the relative efficiency of vasodilators on hemodynamics in AHFS patients. The present study aimed to assess the differences in hemodynamic responses between intravenous carperitide and nicorandil in patients with AHFS. Thirty-eight consecutive patients were assigned to receive 48-h continuous infusion of carperitide (n = 19; 0.0125-0.05 μg/kg/min) or nicorandil (n = 19; 0.05-0.2 mg/kg/h). Hemodynamic parameters were estimated at baseline, and 2, 24, and 48 h after drug administration using echocardiography. After 48 h of infusion, systolic BP was significantly more decreased in the carperitide group compared with that in the nicorandil group (22.1 ± 20.0 % vs 5.3 ± 10.4 %, P = 0.003). While both carperitide and nicorandil significantly improved hemodynamic parameters, improvement of estimated pulmonary capillary wedge pressure was greater in the carperitide group (38.2 ± 14.5 % vs 26.5 ± 18.3 %, P = 0.036), and improvement of estimated cardiac output was superior in the nicorandil group (52.1 ± 33.5 % vs 11.4 ± 36.9 %, P = 0.001). Urine output for 48 h was greater in the carperitide group, but not to a statistically significant degree (4203 ± 1542 vs 3627 ± 1074 ml, P = 0.189). Carperitide and nicorandil were differentially effective in improving hemodynamics in AHFS patients. This knowledge may enable physicians in emergency wards to treat and manage patients with AHFS more effectively and safely.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Hattori H,Minami Y,Mizuno M,Yumino D,Hoshi H,Arashi H,Nuki T,Sashida Y,Higashitani M,Serizawa N,Yamada N,Yamaguchi J,Mori F,Shiga T,Hagiwara Ndoi
10.1007/s00380-012-0252-7subject
Has Abstractpub_date
2013-05-01 00:00:00pages
345-51issue
3eissn
0910-8327issn
1615-2573journal_volume
28pub_type
临床试验,杂志文章abstract::A drawback of visual assessment for late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) is the subjectivity and reproducibility of the results. The aim of this study was to investigate the relationship between left ventricular (LV) reverse remodeling in response to optimal pharmacotherapies and the d...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1196-3
更新日期:2018-12-01 00:00:00
abstract::Distal anastomosis technique affects graft patency and long-term outcomes in coronary artery bypass grafting, however, there is no standard for the appropriate length of distal anastomosis. The purpose of this study is to evaluate whether longer distal anastomosis provides higher quality of distal anastomosis and bett...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0880-4
更新日期:2017-01-01 00:00:00
abstract::Morphological and functional changes of free arterial grafts in dogs were studied for 3 weeks after implantation and the changes were compared to those in implanted free vein grafts. In the arterial grafts, endothelial cells with abundant pinocytotic vesicles and some cytoplasmic folds were observed by transmission an...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744868
更新日期:1992-01-01 00:00:00
abstract::An expandable polytetrafluoroethylene (ePTFE) covered stent is generally employed to seal coronary artery perforation. The frequency of ePTFE covered stent use is relatively low; thus, only a handful of studies have reported neointimal coverage and endothelialization inside the deployed ePTFE and clinical time course ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0964-9
更新日期:2017-06-01 00:00:00
abstract::Downregulation of glucose and fatty acid oxidation occurs in heart failure (HF). Trimetazidine reduces fatty acid oxidation and increases glucose oxidation. In this single-blind study, trimetazidine, 20 mg three times per day (n = 51) or placebo (n = 36) was added to treatment of 87 HF patients receiving optimal HF th...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1118-x
更新日期:2009-07-01 00:00:00
abstract::Levels of testosterone and estradiol influence the incidence of cardiovascular diseases: generally, estrogens in females are protective before menopause; coronaropathies, hypertension, and dyslipidemias in normal men are more frequent at comparable ages. We investigated the modulation by castration of in vitro vasorea...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1098-x
更新日期:2009-03-01 00:00:00
abstract::Sleep-disordered breathing (SDB) has a critical association with mortality and morbidity of patients with chronic heart failure (CHF). Troponin T is a marker of ongoing myocardial damage and predicts adverse clinical outcomes in patients with CHF. Carnitine plays an important role in the utilization of fatty acids in ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0479-6
更新日期:2015-05-01 00:00:00
abstract::The aim of the study was to evaluate systemic right ventricular (RV) dyssynchrony in patients with congenitally corrected transposition of the great arteries (CCTGA) and transposition of the great arteries (TGA) with New York Heart Association functional class (NYHA FC) < III. We used cardiac magnetic resonance (CMR) ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1144-2
更新日期:2018-09-01 00:00:00
abstract::During cardiopulmonary bypass (CPB) mechanical stress and the contact of blood with artificial surfaces lead to the activation of pro- and anticoagulant systems and the complement cascade, and to changes in cellular components. This phenomenon causes the "postperfusion-syndrome", with leukocytosis, increased capillary...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01747190
更新日期:1996-01-01 00:00:00
abstract::Lamotrigine has been used for patients with epilepsy and/or bipolar disorder, overdose of which induced the hypotension, elevation of the atrial pacing threshold, cardiac conduction delay, wide complex tachycardia, cardiac arrest and Brugada-like electrocardiographic pattern. To clarify how lamotrigine induces those c...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01716-8
更新日期:2020-11-02 00:00:00
abstract::The hemodynamic load due to physical activity leads to structural and functional cardiac adaptations known as "Athlete's heart". We aimed to compare myocardial performance in different groups of trained athletes by means of 3D echocardiography and 3D speckle tracking echocardiography (3D-STE). 66 athletes [26 strength...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0520-9
更新日期:2015-05-01 00:00:00
abstract::Cardiopulmonary polygraphy (PG) demonstrates not only parameters for sleep disordered breathing (SDB) but also hemodynamics. We previously developed a software that detects lung to fingertip circulation time (LFCT) derived from PG dataset and reported that those LFCT reflected the cardiac output. The purpose of this s...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01657-2
更新日期:2021-01-01 00:00:00
abstract::Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) resulted in different degrees of damage to the heart muscle, and yet, when factors related to in-hospital outcomes were examined, these two subsets were often lumped together as non-STelevation acute coronary syndrome. Therefore, we investigated ...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-008-1141-y
更新日期:2009-11-01 00:00:00
abstract::Compared to the general population, elderly patients with cardiovascular disease have a higher prevalence of sarcopenia, and it shows an association with increased mortality risk. Although several studies have indicated that atherosclerosis may cause sarcopenia in community dwelling elderly subjects, the association b...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01554-8
更新日期:2020-06-01 00:00:00
abstract::Atrial tachyarrhythmias often originate from the superior vena cava (SVC), and right superior (RSPV) and inferior pulmonary veins (RIPV). However, a precise differentiation of those origins is challenging using the standard 12-lead electrocardiogram (ECG) P-wave morphology due to the anatomical proximity. The recently...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01483-1
更新日期:2020-02-01 00:00:00
abstract::There is controversial data regarding the relationship between uric acid (UA) and coronary artery disease and cardiovascular events. Despite the deleterious effects of hyperuricemia on endothelial function, the effect of UA on myocardial ischemia has not been previously studied. We aimed to investigate the relationshi...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0609-1
更新日期:2016-03-01 00:00:00
abstract::Coronary blood flow was quantified using the thrombosis in myocardial infarction (TIMI) frame-count method. This measurement has been significantly correlated with flow velocity measured invasively by use of a Doppler flow wire. Coronary artery ectasia or aneurysm (CEA) is thought to be present in patients with a slow...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0831-y
更新日期:2005-09-01 00:00:00
abstract::Intracellular Na(+) ([Na(+)](i)) regulation plays a crucial role in the structural, mechanical, and electrical properties of myocardium. It is assumed that the [Na(+)](i) handling system may differ not only between normal and diseased hearts but also regionally within a heart. To gain new insight concerning disease- a...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1071-8
更新日期:2009-01-01 00:00:00
abstract::Coronary artery spasm is involved in the pathogenesis of various cardiac disorders. We investigated patients with a history of syncope who underwent elective coronary angiography. We retrospectively analyzed 5781 consecutive patients who had diagnostic or follow-up angiography during a 26-year period. During this peri...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1046-8
更新日期:2018-02-01 00:00:00
abstract::Even though drug-coated balloon (DCB) angioplasty has emerged as a treatment option for drug-eluting stent in-stent restenosis (DES-ISR), the most effective treatment strategy for DES-ISR is still under debate. Therefore, we compared long-term clinical outcomes following DCB treatment of DES-ISR with those following 2...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0741-6
更新日期:2016-09-01 00:00:00
abstract::Insulin resistance (IR) is now considered to be a risk factor for coronary arterial atherosclerosis and is likely to be involved in a limited endothelium-dependent vasodilatory function in peripheral circulation. We investigated whether IR impairs endothelial vasodilator function in the noninfarcted coronary artery. I...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-007-1002-0
更新日期:2008-01-01 00:00:00
abstract::The efficacy of second-generation drug-eluting stent (DES) for the treatment of left main disease (LM) and/or three vessel disease (3VD) remains unclear. We compared 2-year outcomes of second- versus first -generation DES implantation among patients with LM and/or 3VD and to assess the differential of risk by complexi...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0824-z
更新日期:2016-12-01 00:00:00
abstract::During left nephrectomy in a 35-year-old woman with a left renal cell carcinoma extending into the inferior vena cava (IVC) and right atrium, cardiac arrest occurred. Immediate transesophageal echocardiography demonstrated that the event was caused by a pulmonary tumor embolism. Emergent cardiopulmonary bypass (CPB) w...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02767048
更新日期:1997-01-01 00:00:00
abstract::The purpose of this study was to investigate the use of hepatocyte growth factor as a biochemical marker for acute myocardial infarction. Several biochemical markers are used for noninvasive detection of acute myocardial infarction. However, hepatocyte growth factor has not been used previously for this purpose. We me...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02766790
更新日期:1997-01-01 00:00:00
abstract::The effects of nifedipine on regional dysfunction during pacing-induced ischemia were studied in eight patients with coronary artery disease. Single-plane left ventriculograms were obtained using a high-fidelity micromanometer-tipped catheter in the control and post-pacing periods both before and after pretreatment wi...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02073655
更新日期:1985-11-01 00:00:00
abstract::The clinical and immunological follow-up of a 38-year-old female patient with hypereosinophilic syndrome and classical cardiac involvement, but without demonstrable degranulation of eosinophils and lacking binding of a specific antibody for activated eosinophils, is presented. Instead, the patient demonstrated all the...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058696
更新日期:1990-01-01 00:00:00
abstract::Recent evidence has shown that apoptotic cells are present in human atherosclerotic lesions. However, the molecular mechanism of the induction of apoptosis in atherosclerotic lesions is not clear. Since T cells are present in almost all stages of atherosclerosis, we examined whether T cells can modulate the expression...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Although a previous randomized study showed that the use of atrial natriuretic peptide (carperitide) improved the long-term prognosis of patients with heart failure, its effect on short-term prognosis remains unclear. We retrospectively identified patients who were admitted to our tertiary-care center with acute decom...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0952-0
更新日期:2017-08-01 00:00:00
abstract::Chronic kidney disease (CKD) is well known to be associated with an increased incidence of coronary artery disease (CAD). Diabetes mellitus (DM) and hypertension (HTN), both of which are traditional risk factors for CAD, are the two most common causes of CKD. However, the influence of CKD on coronary atherosclerosis i...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-01334-5
更新日期:2019-07-01 00:00:00
abstract::Pre-procedural valvuloarterial impedance (Zva) is considered as a useful predictor of mortality in patients diagnosed as having severe aortic stenosis (AS) who undergo transcatheter aortic valve implantation (TAVI). However, the prognostic significance of post-procedural Zva remains unclear. We aimed to evaluate the p...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-01329-2
更新日期:2019-06-01 00:00:00