Abstract:
:Sensitive cardiac troponin I (cTnI) predicts all-cause and cardiovascular mortality in various clinical settings. However, its clinical significance in hemodialysis (HD) patients with preserved left ventricular ejection fraction (LVEF) has not been fully elucidated. This study investigated the association of cTnI with LV morphology and function, and its long-term outcome in HD patients with preserved LVEF. This prospective study consists of 96 HD patients with preserved LVEF (69 ± 8 years and 63% male) who underwent two-dimensional echocardiographic examination and biomarker tests including cTnI, brain natriuretic peptide, and high-sensitive C-reactive protein. The primary endpoint was all-cause death and secondary endpoint was cardiovascular death. Factors independently associated with cTnI were systolic blood pressure (β = - 0.239, p = 0.011), heart rate (β = 0.216, p = 0.021), LV mass index (β = 0.231, p = 0.020), and E to e' ratio (β = 0.237, p = 0.016). During a mean follow-up of 3.6 years, primary and secondary endpoints were observed in 23 (24%) and 18 (19%) patients, respectively. In the multivariate Cox proportional hazard analysis, the upper cTnI tertile has significantly increased risk of all-cause mortality [hazard ratio (HR), 2.69; 95% confidence interval (CI), 1.139-6.386; p = 0.024] and that of cardiovascular death (HR, 4.56; 95% CI 2.021-16.968; p = 0.006) independent of echocardiographic measures and other serum biomarkers. In HD patients with preserved LVEF, serum cTnI levels were significantly associated with diastolic function and risk of mortality independent of echocardiographic variables and other biomarkers.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Otsuka K,Nakanishi K,Shimada K,Nakamura H,Inanami H,Nishioka H,Fujimoto K,Kasayuki N,Yoshiyama Mdoi
10.1007/s00380-018-1192-7subject
Has Abstractpub_date
2018-11-01 00:00:00pages
1334-1342issue
11eissn
0910-8327issn
1615-2573pii
10.1007/s00380-018-1192-7journal_volume
33pub_type
杂志文章abstract::We assessed the plaque disruption in 245 consecutive patients with acute coronary syndrome undergoing percutaneous coronary intervention. The plaque fissure was diagnosed with optical coherence tomography, and intravascular ultrasound was used to determine arterial remodeling. Of them, 26 fissures were found in this s...
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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