Abstract:
:Hydrogen peroxide (H2O2) elicited concentration-dependent relaxation of endothelium-denuded rings of porcine coronary arteries. The relaxation induced by the H2O2 was markedly attenuated by 10 microM 1H-[1,2,4]oxadiazolo [4,3,a]quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase, or by 100 nM charybdotoxin, an inhibitor of large-conductance Ca2+-activated K+ (KCa) channels. A combination of the ODQ and charybdotoxin abolished the H2O2-induced relaxation. Pretreatment with 25 microM of an Rp stereoisomer of adenosine-3',5'-cyclic monophosphothioate (Rp-cAMPS), 20 microM glibenclamide, or 1 mM 4-aminopyridine did not affect the vascular response to H2O2. The presence of catalase at 1000 U/ml significantly attenuated the H2O2-induced relaxation. Exposure of cultured smooth muscle cells to H2O2 activated KCa channels in a concentration-dependent manner in cell-attached patches. Pretreatment with catalase significantly inhibited the activation of KCa channels. Rp-cAMPS did not inhibit the H2O2-induced activation of KCa channels. The activation of KCa channels by H2O2 was markedly decreased in the presence of ODQ. However, even in the presence of ODQ, H2O2 activated KCa channels in a concentration-dependent manner. In inside-out patches, H2O2 significantly activated KCa channels through a process independent of cyclic guanosine 3',5'-monophosphate (cGMP). In conclusion, H2O2 elicits vascular relaxation due to activation of KCa channels, which is mediated partly by a direct action on the channel and partly by activation of soluble guanylate cyclase, resulting in the generation of cGMP.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Hayabuchi Y,Nakaya Y,Matsuoka S,Kuroda Ydoi
10.1007/BF02750638subject
Has Abstractpub_date
1998-01-01 00:00:00pages
9-17issue
1eissn
0910-8327issn
1615-2573journal_volume
13pub_type
杂志文章abstract::During cardiopulmonary bypass (CPB) mechanical stress and the contact of blood with artificial surfaces lead to the activation of pro- and anticoagulant systems and the complement cascade, and to changes in cellular components. This phenomenon causes the "postperfusion-syndrome", with leukocytosis, increased capillary...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01747190
更新日期:1996-01-01 00:00:00
abstract::Liver cirrhosis (LC), which may result in hepatic failure or cancer, has been reported in patients after Fontan procedure. The purpose of this study was to clarify the frequency and histological characteristics of LC, and to evaluate the risk factors and serological markers of LC with Fontan circulation. Retrospective...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0743-4
更新日期:2016-09-01 00:00:00
abstract::Aortic dissection is a life-threatening cardiovascular disease with high in-hospital mortality. However, the risk factors of aortic dissection have not been fully elucidated. Obstructive sleep apnea (OSA) has been increasingly recognized as an independent cardiovascular risk factor. Among the underlying mechanisms to ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0149-x
更新日期:2012-05-01 00:00:00
abstract::Sleep-disordered breathing (SDB) has a critical association with mortality and morbidity of patients with chronic heart failure (CHF). Troponin T is a marker of ongoing myocardial damage and predicts adverse clinical outcomes in patients with CHF. Carnitine plays an important role in the utilization of fatty acids in ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0479-6
更新日期:2015-05-01 00:00:00
abstract::Previous studies suggested that sleep-disordered breathing was associated with cardiovascular diseases such as heart failure (HF). Recently, algorithms of cardiac implantable electronic devices (CIEDs) have been developed to detect advanced sleep apnea (SA); the Apnea Scan (AP Scan) being an example. The purpose of th...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01551-6
更新日期:2020-06-01 00:00:00
abstract::In the original publication of the article, the unit of hand in Fig. 2 was wrongly given as "N/kg" instead of "kg". ...
journal_title:Heart and vessels
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00380-018-1132-6
更新日期:2018-07-01 00:00:00
abstract::It is well known the relationship between oxidative stress and vascular function. However, association between total antioxidative capacity and arterial stiffness was not studied in patients with hypertension (HT). This study investigated whether total antioxidative capacity is associated with arterial stiffness and w...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1129-7
更新日期:2009-09-01 00:00:00
abstract::The inducibility of reentry was compared for four QT patterns in a heart conduction simulation model. Local (L) and gradual (G) QT prolongation models are more susceptible to reentry induction than the no (N) QT prolongation model (reentry induced episodes for N, L, and G numbered 90, 120, and 122, respectively). This...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::High levels of serum phosphate are associated with calcification of human smooth muscle cells (HSMCs). We investigated whether inhibition of protein kinase A (PKA) and mitogen-activated protein kinase (MAPK) signals [p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK)] can reduce inorga...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0427-x
更新日期:2014-09-01 00:00:00
abstract::Anatomic continuity between the anterior mitral leaflet and the aortic root may predispose those patients with aortic root pathology to functional changes of the mitral valve without any involvement of this valve. A 34-year-old man presented with aortic valve endocarditis. Transthoracic echocardiograpy showed severe a...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-004-0761-0
更新日期:2005-02-01 00:00:00
abstract::Therapeutic devices for acute myocardial infarction (AMI) have evolved dramatically in recent years. However, the impact of the Killip classification of AMI outcomes in patients undergoing aggressive percutaneous coronary intervention remains unclear. We performed a 10-year retrospective review of 2062 patients diagno...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1017-0
更新日期:2017-12-01 00:00:00
abstract::Existing methods to calculate pre-test probability of obstructive coronary artery disease (CAD) have been established using selected high-risk patients who were referred to conventional coronary angiography. The purpose of this study is to develop and validate our new method for pre-test probability of obstructive CAD...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0515-6
更新日期:2015-09-01 00:00:00
abstract::Early and long-term outcomes in elderly patients who underwent isolated aortic valve replacement (iAVR) are well defined. Conflicting data exist in elderly patients who underwent AVR plus coronary artery bypass grafting (CABG). We sought to evaluate the early and long-term outcomes of combined AVR + CABG in patients o...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01519-6
更新日期:2020-04-01 00:00:00
abstract::Although drug-eluting stents have improved clinical outcomes, percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) remains a challenging procedure in terms of thrombus management. A new-generation P2Y12 receptor inhibitor, prasugrel, provides more rapid and potent antiplatelet action compared wit...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01686-x
更新日期:2020-09-09 00:00:00
abstract::It has been demonstrated that S1P receptors affect heart ischaemia-reperfusion (IR) induced injury. However, whether S1P receptors affect IR-induced cardiac death has not been investigated. The aim of this paper is to demonstrate the role of S1P receptors in IR-induced cardiac death. Healthy adult male Sprague-Dawley ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-01323-8
更新日期:2019-06-01 00:00:00
abstract::An 18-year-old woman with catecholaminergic polymorphic ventricular tachycardia (CPVT) underwent pulmonary vein isolation (PVI) because of frequent and inappropriate shocks from an implantable cardioverter defibrillator (ICD) associated with atrial fibrillation (AF) with a rapid ventricular response. While the PVI did...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-009-1214-6
更新日期:2010-09-01 00:00:00
abstract::Transcatheter aortic valve implantation (TAVI) is recommended for patients who are inoperable or at high risk for surgical aortic valve replacement (SAVR). Corticosteroid therapy is considered to be a risk factor for SAVR, but there is a paucity of information about TAVI in patients taking corticosteroids. The aim of ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0996-1
更新日期:2017-10-01 00:00:00
abstract::Incretin hormones have been reported to have cytoprotective actions in addition to their glucose-lowering effects. We evaluated whether teneligliptin, a novel dipeptidyl peptidase-4 (DPP-4) inhibitor, affects left ventricular (LV) function in patients with type 2 diabetes mellitus (T2DM). Twenty-nine T2DM patients not...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0724-7
更新日期:2016-08-01 00:00:00
abstract::We recently reported that preoperative endothelial dysfunction [i.e., reactive hyperemia index (RHI) ≤ 1.64] predicted short-term postoperative adverse events in patients undergoing cardiovascular surgery. However, the relationship between preoperative RHI and long-term cardiovascular risk in these patients is unclear...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1248-8
更新日期:2019-02-01 00:00:00
abstract::Pleural effusions following coronary artery bypass grafting (CABG) have been reported in 65%-89% of the cases. The majority of pleural effusions are left-sided, of little significance, and resolve spontaneously. However, a few pleural effusions require specific therapeutics. We report clinical and pleural histologic f...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0930-4
更新日期:2007-01-01 00:00:00
abstract::The coronary flow velocity reserve (CFVR), a measure of endothelial function in coronary circulation, can be measured semi-invasively in the left anterior descending coronary artery by using stress transesophageal echocardiography (TEE). During the same stress TEE, aortic distensibility indices (elastic modulus [E(p)]...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0939-8
更新日期:2007-03-01 00:00:00
abstract::There is no proven therapy for heart failure with preserved ejection fraction (HFpEF). Research has shown beneficial responses to cardiac rehabilitation (CR) among HF patients. To date, there are no reports comparing those responses between patients with HFpEF and those with reduced ejection fraction (HFrEF). The purp...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1128-2
更新日期:2018-08-01 00:00:00
abstract::Little evidence exists regarding the need for a reduction in postoperative heart rate after repair of type A acute aortic dissection. This single-center retrospective study was conducted to determine if lower heart rate during the early postoperative phase is associated with improved long-term outcomes after surgery f...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0486-7
更新日期:2015-05-01 00:00:00
abstract::Morphological and functional changes of free arterial grafts in dogs were studied for 3 weeks after implantation and the changes were compared to those in implanted free vein grafts. In the arterial grafts, endothelial cells with abundant pinocytotic vesicles and some cytoplasmic folds were observed by transmission an...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744868
更新日期:1992-01-01 00:00:00
abstract::It has been shown that green tea catechins (GTC) suppress proliferation of vascular smooth muscle cells (VSMCs) and that epigallocatechin-3-gallate (EGCG), which is a major constituent of GTC, selectively inhibits the platelet-derived growth factor-BB (PDGF-BB)-induced intracellular signaling transduction pathway. Vas...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-004-0768-6
更新日期:2004-09-01 00:00:00
abstract::Based on the unique property of fluorine-18 fluorodeoxyglucose, localization and follow-up of hypermetabolic processes is possible with positron emission tomography (PET). The dual-modality PET/computed tomography (CT) systems provide intrinsically fused morphologic and functional data in a single examination. We repo...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-004-0808-2
更新日期:2005-07-01 00:00:00
abstract::A drawback of visual assessment for late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) is the subjectivity and reproducibility of the results. The aim of this study was to investigate the relationship between left ventricular (LV) reverse remodeling in response to optimal pharmacotherapies and the d...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1196-3
更新日期:2018-12-01 00:00:00
abstract::Between 1987 and 1989, twenty-two patients who received combined heart-lung transplantation were autopsied at La Pitie Salpetriere Hospital in Paris. With the exception of two recipients who survived for 2 months and 4 months, respectively, the majority of the patients died in the early postoperative period (the mean ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02125099
更新日期:1991-01-01 00:00:00
abstract::In addition to plaque rupture (PR), calcified nodule (CN) may also have the potential to develop into arterial thrombus in the peripheral arteries. This study evaluated the distribution of plaque ruptures and calcified nodules in the peripheral arteries and their impact on the outcome of endovascular therapy (EVT). Co...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0984-5
更新日期:2017-10-01 00:00:00
abstract::While recent guidelines for the treatment of acute heart failure syndromes (AHFS) recommend pharmacotherapy with vasodilators in patients without excessively low blood pressure (BP), few reports have compared the relative efficiency of vasodilators on hemodynamics in AHFS patients. The present study aimed to assess th...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
doi:10.1007/s00380-012-0252-7
更新日期:2013-05-01 00:00:00