Abstract:
:This study examined whether brief repeated myocardial ischemia altered free radical generating and scavenging activity in a dog model. In dogs preconditioned with four 5-min left anterior descending coronary artery (LAD) occlusions and reperfusions, we examined transcardiac changes in both the function of neutrophils, cells which are major free radical generators, and in myocardial antioxidant enzyme activity, as an indication of free radical scavenging. Neutrophil function was assessed by determining luminol-enhanced whole blood chemiluminescence (CL) induced by zymosan. Blood was taken simultaneously from the carotid artery and the cardiac vein running along the occluded LAD. Preconditioning with sublethal ischemia significantly reduced whole blood CL in the cardiac vein compared with the carotid artery after the first and fourth 5-min reperfusions, while there was no difference in neutrophil count between these sampling sites. Immediately after brief repeated ischemia and reperfusion, manganese-superoxide dismutase (SOD) activity was significantly enhanced, and glutathione reductase activity was markedly reduced in the ischemic, compared with the non-ischemic, myocardium. There were no differences in the myocardial activities of copper, zinc-SOD, glutathione peroxidase, and glutathione S-transferase between the ischemic and non-ischemic regions. Also, no difference was observed between the reduced myocardial glutathione levels in these regions, although the oxidized glutathione level was significantly higher in the ischemic regions of the subepicardial and subendocardial areas. We demonstrated that brief repeated ischemia affects free radical generating and scavenging systems in the ischemic myocardium.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Hoshida S,Kuzuya T,Yamashita N,Oe H,Fuji H,Hori M,Tada M,Kamada Tdoi
10.1007/BF01744795subject
Has Abstractpub_date
1993-01-01 00:00:00pages
115-20issue
3eissn
0910-8327issn
1615-2573journal_volume
8pub_type
杂志文章abstract::The coronary flow velocity reserve (CFVR), a measure of endothelial function in coronary circulation, can be measured semi-invasively in the left anterior descending coronary artery by using stress transesophageal echocardiography (TEE). During the same stress TEE, aortic distensibility indices (elastic modulus [E(p)]...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0939-8
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02059969
更新日期:1986-01-01 00:00:00
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
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journal_title:Heart and vessels
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s00380-015-0743-4
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journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-019-01344-x
更新日期:2019-07-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0914-4
更新日期:2006-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058316
更新日期:1987-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
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更新日期:2011-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-07-01 00:00:00
abstract::There is no proven therapy for heart failure with preserved ejection fraction (HFpEF). Research has shown beneficial responses to cardiac rehabilitation (CR) among HF patients. To date, there are no reports comparing those responses between patients with HFpEF and those with reduced ejection fraction (HFrEF). The purp...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1128-2
更新日期:2018-08-01 00:00:00