Abstract:
:MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression. It seems that microRNA-21 (miR-21) and Visfatin, a novel adipocytokine, play roles in inflammation and atherosclerosis. The aim of this study was to investigate the association of miR-21 with Visfatin, inflammation, atherosclerosis and acute coronary syndrome (ACS). Based on coronary angiography and electrocardiogram (ECG), 53 patients with ACS and 52 patients with stable CAD were enrolled in this study. We assayed serum miR-21, Visfatin, and routine chemistries using quantitative reverse transcriptase polymerase chain reaction (QRT-PCR), enzyme-linked immunosorbent assay (ELISA) and automated analyzer, respectively. We used a regression analysis to describe the relationship between the variables. Serum miR-21 level in 2-ΔCt value was significantly higher in ACS patients (10.52 ± 1.01-fold) than the stable CAD patients (4.4 ± 0.79-fold) (F = 4.59, p < 0.001). In addition, serum Visfatin was significantly higher in ACS patients (17.5 ± 0.61 ng/ml) than the stable CAD patients (12.7 ± 0.49 ng/ml) (F = 2.62, p < 0.001). Furthermore, the serum miR-21 level correlated positively with serum Visfatin level (r = 0.26, p = 0.008), hs-CRP (r = 0.29, p = 0.003), age (r = 0.21, p = 0.034) and negatively with HDL-cholesterol (r = -0.28, p = 0.004). We concluded that the increased serum miR-21 and Visfatin may be involved in the pathogenesis of ACS through promoting inflammation or may result from inflammatory responses to ACS. Furthermore, the potential role of miR-21 and Visfatin in plaque instability and inflammation warrants further investigations.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Darabi F,Aghaei M,Movahedian A,Elahifar A,Pourmoghadas A,Sarrafzadegan Ndoi
10.1007/s00380-016-0913-zsubject
Has Abstractpub_date
2017-05-01 00:00:00pages
549-557issue
5eissn
0910-8327issn
1615-2573pii
10.1007/s00380-016-0913-zjournal_volume
32pub_type
杂志文章abstract::Acromegaly, when left untreated, is associated with premature mortality which is chiefly related to cardiovascular complications. We report on a 50-year-old acromegalic woman, resistant to therapy, who died suddenly because of thoracic aortic rupture and massive bleeding into the left pleural space. The postmortem exa...
journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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pub_type: 杂志文章,多中心研究
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 已发布勘误
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0930-4
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0880-4
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pub_type: 杂志文章
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