Abstract:
:Coronary slow flow (CSF) is characterized by delayed opacification of coronary arteries in the absence epicardial occlusive disease. QT duration and dispersion have been reported to be longer in patients with CSF. ACE inhibitors may improve CSF through positive effects on endothelial function. The study included 32 patients having CSF and 25 subjects having normal coronary arteries in coronary angiography. The patients were evaluated with 12-leads electrocardiography and echocardiography before and 3 months after treatment with perindopril. Compared to the control group, maximum corrected QT duration (QTcmax) (432.0 ± 28.9 vs. 407.0 ± 39.1 ms, p = 0.008) and QT dispersion (QTcD) (64.0 ± 16.5 vs. 37.3 ± 12.1 ms, p < 0.001), mitral inflow deceleration time (DT) (251.3 ± 49.4 vs. 218.8 ± 44.5 ms, p = 0.013), and isovolumetric relaxation time (IVRT) (115.8 ± 18.4 vs. 107.2 ± 22.9 ms, p < 0.001) were significantly longer and E/A ratio 0.85 ± 0.2 vs. 1.1 ± 0.3, p = 0.004) was lower in patients with CSF. QTcmax (to 407.0 ± 28.0 ms, p = 0.001), QTcD (to 44.5 ± 11.4 ms, p < 0.001), DT (to 221.6 ± 37.7 ms, p < 0.001) and IVRT (to 103.8 ± 16.1 ms, p < 0.001) were significantly decreased and E/A ratio (to 0.98 ± 0.3, p < 0.001) was significantly increased after treatment with perindopril. Coronary slow may be associated with prolonged QT interval and increased QT dispersion and impaired diastolic filling. Perindopril may be helpful in restoration of these findings.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Guntekin U,Gumrukcuoglu HA,Gunes Y,Gunes A,Simsek H,Sahin M,Sezen Y,Akdağ S,Tuncer Mdoi
10.1007/s00380-010-0058-4subject
Has Abstractpub_date
2011-07-01 00:00:00pages
357-62issue
4eissn
0910-8327issn
1615-2573journal_volume
26pub_type
杂志文章abstract::Coronary blood flow was quantified using the thrombosis in myocardial infarction (TIMI) frame-count method. This measurement has been significantly correlated with flow velocity measured invasively by use of a Doppler flow wire. Coronary artery ectasia or aneurysm (CEA) is thought to be present in patients with a slow...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0831-y
更新日期:2005-09-01 00:00:00
abstract::Hyperuricemia is known to be associated with adverse outcomes in cardiovascular intensive care patients, but its mechanisms are unknown. A total of 569 emergency department patients were prospectively analyzed and assigned to intensive care (ICU group, n = 431) or other departments (n = 138). Uric acid (UA) levels wer...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01608-x
更新日期:2020-10-01 00:00:00
abstract::Pleural effusions following coronary artery bypass grafting (CABG) have been reported in 65%-89% of the cases. The majority of pleural effusions are left-sided, of little significance, and resolve spontaneously. However, a few pleural effusions require specific therapeutics. We report clinical and pleural histologic f...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0930-4
更新日期:2007-01-01 00:00:00
abstract::T cells are involved in the pathogenesis of atherosclerosis. We aimed to search for any association between the peripheral T-cell activities and atherogenic risk factors in healthy subjects. Fifty male volunteers (age 22.0 +/- 2.4 years) were enrolled. No subject had any chronic disease or was under any drug treatment...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0893-x
更新日期:2006-07-01 00:00:00
abstract::An expandable polytetrafluoroethylene (ePTFE) covered stent is generally employed to seal coronary artery perforation. The frequency of ePTFE covered stent use is relatively low; thus, only a handful of studies have reported neointimal coverage and endothelialization inside the deployed ePTFE and clinical time course ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0964-9
更新日期:2017-06-01 00:00:00
abstract::Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary arterial pressure and vascular resistance. Despite advances in therapy for PAH, its treatment and prognosis remain poor. We aimed to investigate whether the transplantation of bone marrow mesenchymal stem cells (MSCs) overexp...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0395-1
更新日期:2014-07-01 00:00:00
abstract::The use of cine-computed tomography scanning is described in evaluating cardiac function in a patient with a bileaflet mitral valve prosthesis (St. Jude medical valve) and in a second patient with both mitral and aortic bileaflet prostheses. Both biventricular and prosthesis function were assessed successfully. ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058316
更新日期:1987-01-01 00:00:00
abstract::Thoracic outlet syndrome (TOS) is caused by compression of peripheral nerves and vascular structures along their course through the upper thoracic aperture to the axilla. The aim of our study was to analyze long-term outcomes of different treatments stratified by symptom severity. We performed a retrospective analysis...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0112-2
更新日期:2011-11-01 00:00:00
abstract::We report the case of a newborn with an aneurysmal aorto-left ventricular tunnel causing significant paravalvular aortic regurgitation and obstruction of the right ventricular outflow tract (RVOT), coexisting with a bicuspid aortic valve. The coexistence of the two malformations together with the obstruction of the RV...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0445-8
更新日期:2015-01-01 00:00:00
abstract::The relationship between central pulse pressure (CPP) measured at the time of primary percutaneous coronary intervention (PPCI) and long-term prognosis after ST-segment elevation myocardial infarction (STEMI) has not been investigated. CPP measurements were performed in 1348 patients with STEMI (327 women; mean age 62...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-019-01344-x
更新日期:2019-07-01 00:00:00
abstract::The aim of this study was to examine the efficacy and safety of this novel epicardial circumferential left atrial ablation (CLAA) with pulmonary vein isolation (PVI) in sustained atrial fibrillation (AF). Thirty domestic pigs were divided equally into 3 groups: AF without ablation (AF group), AF with PVI (PVI group), ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0594-4
更新日期:2015-09-01 00:00:00
abstract::Subintimal or false lumen stent deployment is a rare complication of percutaneous coronary interventions. The most balloon-induced small non-flow limiting dissections heal spontaneously and can be treated medically with close observation if distal coronary flow is not compromised. However, the complex and severe flow-...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1052-y
更新日期:2008-07-01 00:00:00
abstract::In addition to plaque rupture (PR), calcified nodule (CN) may also have the potential to develop into arterial thrombus in the peripheral arteries. This study evaluated the distribution of plaque ruptures and calcified nodules in the peripheral arteries and their impact on the outcome of endovascular therapy (EVT). Co...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0984-5
更新日期:2017-10-01 00:00:00
abstract::Myocardial fibrosis and microvascular dysfunction are key determinants of outcome in heart failure (HF); we examined their relationship in patients with HF. Our study included 61 consecutive patients with HF but without coronary stenosis. All underwent gadolinium-enhanced cardiac magnetic resonance to evaluate late ga...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0816-z
更新日期:2016-12-01 00:00:00
abstract::Primary cardiac osteosarcomas are uncommon tumors. Their growth pattern is aggressive and the prognosis is poor. A 34-year-old, 7-month pregnant woman with a primary cardiac osteosarcoma associated with the anterior mitral leaflet and connected to the interatrial septum, causing nearly subtotal obstruction of the mitr...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0830-z
更新日期:2006-01-01 00:00:00
abstract::We explored the influence of global longitudinal strain (GLS) measured with two-dimensional speckle-tracking echocardiography on left ventricular mass regression (LVMR) in patients with pure aortic stenosis (AS) and normal left ventricular function undergoing aortic valve replacement (AVR). The study population includ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0308-8
更新日期:2013-11-01 00:00:00
abstract::The purpose of this study was to investigate the use of hepatocyte growth factor as a biochemical marker for acute myocardial infarction. Several biochemical markers are used for noninvasive detection of acute myocardial infarction. However, hepatocyte growth factor has not been used previously for this purpose. We me...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02766790
更新日期:1997-01-01 00:00:00
abstract::The modulation of L-type Ca2+ currents (I(Ca,L)) by the basal activities of G proteins was studied in adult guinea pig ventricular myocytes by whole-cell patch-clamp techniques. With intrapipette guanosine triphosphate (GTP) (100 microM), a specific inhibition of G1 proteins by pertussis toxin (PTX) produced an increa...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800070013
更新日期:2000-01-01 00:00:00
abstract::Hydrogen peroxide (H2O2) elicited concentration-dependent relaxation of endothelium-denuded rings of porcine coronary arteries. The relaxation induced by the H2O2 was markedly attenuated by 10 microM 1H-[1,2,4]oxadiazolo [4,3,a]quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase, or by 100 nM charybdotox...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02750638
更新日期:1998-01-01 00:00:00
abstract::Ischemic cardiomyopathy complicated by severe mitral regurgitation (MR) has a poor prognosis. In such cases, whether mitral valve repair for MR improves the prognosis of survival remains unclear. In this study, 50 patients diagnosed with ischemic cardiomyopathy at our hospital between August 1991 and August 1996 were ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-004-0763-y
更新日期:2004-07-01 00:00:00
abstract::Eicosapentaenoic acid (EPA), a member of the omega-3 polyunsaturated fatty acid family, prevents cardiovascular disease. C-reactive protein (CRP) is a marker of inflammation, which promotes atherosclerosis. The aim of this study was to investigate the relationship among EPA, CRP, and the prevalence of peripheral arter...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0384-4
更新日期:2014-07-01 00:00:00
abstract::Etiopathogenesis of coronary artery ectasia (CAE), which is defined as abnormal dilatation of a segment of the coronary artery to 1.5 times of an adjacent normal coronary artery segment, is unclear. However, it is speculated that CAE develops in the atherosclerosis process through degeneration of coronary artery media...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1087-0
更新日期:2009-03-01 00:00:00
abstract::Although the suction force that moves blood into the left ventricle during early diastole is thought to play an important role in diastolic function, there have been a few studies of this phenomenon in normal children. Suction force is measured as the intraventricular pressure difference (IVPD) and intraventricular pr...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1239-9
更新日期:2019-02-01 00:00:00
abstract::Compared to conscious sedation (CS), the use of general anesthesia (GA) in pulmonary vein isolation (PVI) is associated with a lower recurrence rate of atrial fibrillation (AF). GA may improve catheter stability and mapping system accuracy compared to CS, but its influence on contact force (CF) parameters during ipsil...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0961-z
更新日期:2017-08-01 00:00:00
abstract::While recent guidelines for the treatment of acute heart failure syndromes (AHFS) recommend pharmacotherapy with vasodilators in patients without excessively low blood pressure (BP), few reports have compared the relative efficiency of vasodilators on hemodynamics in AHFS patients. The present study aimed to assess th...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
doi:10.1007/s00380-012-0252-7
更新日期:2013-05-01 00:00:00
abstract::Compared to the general population, elderly patients with cardiovascular disease have a higher prevalence of sarcopenia, and it shows an association with increased mortality risk. Although several studies have indicated that atherosclerosis may cause sarcopenia in community dwelling elderly subjects, the association b...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01554-8
更新日期:2020-06-01 00:00:00
abstract::The thrombotest (TT) technique has been widely used in Japan for monitoring oral anticoagulant therapy (OAT). The therapeutic range was originally recommended to be 10%-25%. However, the International Committee for Standardization in Hematology/International Committee on Thrombosis and Hemostasis (ICSH/ICTH) recommend...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
doi:10.1007/pl00007265
更新日期:2000-01-01 00:00:00
abstract::Due to the complex profile of atherosclerotic risk factors, an integrated analysis of a specific individual is difficult. Endothelial function reflects a composite of various risk factors, and may be used as an optimal tool to estimate the overall atherosclerotic risk. In this study, we investigated the value of digit...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1118-4
更新日期:2018-07-01 00:00:00
abstract::Although drug-eluting stents have improved clinical outcomes, percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) remains a challenging procedure in terms of thrombus management. A new-generation P2Y12 receptor inhibitor, prasugrel, provides more rapid and potent antiplatelet action compared wit...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01686-x
更新日期:2020-09-09 00:00:00
abstract::Direct oral anticoagulants (DOACs), such as rivaroxaban, reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (NVAF). However, it is still unclear whether the stroke reduction benefit outweighs the bleeding risk in elderly Japanese patients with NVAF. The Xarelto Post-Author...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01487-x
更新日期:2020-03-01 00:00:00