Effect of serum uric acid on the positive predictive value of dobutamine stress echocardiography.

Abstract:

:There is controversial data regarding the relationship between uric acid (UA) and coronary artery disease and cardiovascular events. Despite the deleterious effects of hyperuricemia on endothelial function, the effect of UA on myocardial ischemia has not been previously studied. We aimed to investigate the relationship between UA and myocardial ischemia that was identified using dobutamine stress echocardiography (DSE). In this retrospective study, the laboratory and DSE reports of 548 patients were reviewed. The patients were divided into two groups based on the presence of ischemia and further subdivided into three groups according to the extent of ischemia (none, ischemia in 1-3 segments, ischemia in >3 segments). Serum UA levels were compared. Determinants of ischemia were assessed using a regression model. UA was increased in patients with ischemia and was correlated with the number of ischemic segments (p < 0.001). A cutoff value of UA > 5 mg/dl had 63.9 % sensitivity, 62.0 % specificity, 42.5 % positive predictive value (PPV), and 79.6 % negative predictive value for ischemia. When the positive DSE exams were further sorted according to the UA cutoff, the PPV of DSE increased from 80.2 to 94.0 %. Uric acid (odds ratio 1.51; 95 % CI 1.14-1.99), diabetes mellitus, HDL and glomerular filtration rate were found to be independent determinants of myocardial ischemia in DSE. Increased UA is associated with both the presence and extent of DSE-identified myocardial ischemia. A UA cutoff may be a good method to improve the PPV of DSE.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Aribas A,Akilli H,Kayrak M,Alibasic H,Yildirim O,Sertdemir AL,Karanfil M,Ozdemir K

doi

10.1007/s00380-014-0609-1

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

382-9

issue

3

eissn

0910-8327

issn

1615-2573

pii

10.1007/s00380-014-0609-1

journal_volume

31

pub_type

杂志文章
  • Increased circulating CD3+/CD31+ T cells in patients with acute coronary syndrome.

    abstract::The number of circulating endothelial progenitor cells (EPCs) is considered to be a surrogate marker for coronary artery disease (CAD). Recent studies have identified a novel T-cell subset labeled with CD3(+)/CD31(+), which is necessary for EPC colony formation and constitutes the central cluster. However, the clinica...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-012-0284-z

    authors: Kakizaki M,Nobori K,Watanabe H,Iino K,Ishida M,Ito H

    更新日期:2013-09-01 00:00:00

  • Assessment of vascular autonomic function using peripheral arterial tonometry.

    abstract::Peripheral autonomic function is impaired in diabetic polyneuropathy. However, it is difficult to evaluate it due to the lack of non-invasive quantitative assessment. We aimed to establish a novel index to evaluate vascular autonomic function using reactive hyperemia peripheral arterial tonometry (RH-PAT), a widely pe...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-016-0870-6

    authors: Hamada S,Oono A,Ishihara Y,Hasegawa Y,Akaza M,Sumi Y,Inoue Y,Izumiyama H,Hirao K,Isobe M,Sasano T

    更新日期:2017-03-01 00:00:00

  • Insulin resistance and acute coronary syndrome in the young Japanese population have a strong association.

    abstract::There are few data regarding acute coronary syndrome (ACS) in young Japanese patients. We examined the risk factors for ACS in young Japanese patients, especially impaired glucose metabolism. From a database of 789 consecutive patients admitted to our hospital with ACS between 2000 and 2005, we compared risk factors o...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-006-0956-7

    authors: Ikeda N,Nakajima R,Tsunoda T,Nakamura M,Sugi K

    更新日期:2007-05-01 00:00:00

  • An adult case of Bland-White-Garland syndrome with collaterals from the bronchial artery.

    abstract::We report herein an adult case of anomalous origin of the left coronary artery from the pulmonary artery (Bland-White-Garland syndrome; BWG syndrome). The patient had chest discomfort during exercise and signs of mitral regurgitation. We diagnosed him as having BWG syndrome by angiography, and performed surgical treat...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01746067

    authors: Ishihata T,Takeda H,Katohno E,Techigawara M,Owada K,Murata N,Ohta H,Maruyama Y

    更新日期:1994-01-01 00:00:00

  • Correction to: Increased prevalence of cerebral microbleeds in patients with low left ventricular systolic function.

    abstract::In the original publication of the article, under the results section, the following sentence. ...

    journal_title:Heart and vessels

    pub_type: 已发布勘误

    doi:10.1007/s00380-020-01574-4

    authors: Watanabe T,Kanzaki Y,Yamauchi Y,Ito T,Nishida Y,Yamamura K,Komori T,Sohmiya K,Hoshiga M

    更新日期:2020-05-01 00:00:00

  • Immunological features in a case of hypereosinophilic syndrome and myocarditis.

    abstract::The clinical and immunological follow-up of a 38-year-old female patient with hypereosinophilic syndrome and classical cardiac involvement, but without demonstrable degranulation of eosinophils and lacking binding of a specific antibody for activated eosinophils, is presented. Instead, the patient demonstrated all the...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02058696

    authors: Maisch B,Drude L,Kochsiek K

    更新日期:1990-01-01 00:00:00

  • Regional work of the ventricle: wall tension--area relation.

    abstract::We clarified that the set of the isotropic component (T) of wall tension and the area (A) of a selected region of the left ventricular wall expresses the regional work with sufficient accuracy. The area surrounded by the locus of the T-A relation in the T-A plane is approximately equal to the real work done by that re...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02066408

    authors: Sugawara M,Tamiya K,Nakano K

    更新日期:1985-08-01 00:00:00

  • The effects of enoximone (MDL-17043) on forearm venous circulation in healthy volunteers and patients with heart failure.

    abstract::The effect of intravenous enoximone on forearm venous circulation was studied in ten healthy volunteers (group A) and in ten patients with NYHA class III-IV congestive heart failure (group B). Distensibility of the forearm capacitance vessels was assessed from pressure-volume curves by venous occlusion plethysmography...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02058791

    authors: Branzi A,Berardi C,Ferretti RM,Beato E,Magnani G,Melandri G,Zannoli R,Magnani B

    更新日期:1987-01-01 00:00:00

  • Vascular endothelial growth factor stimulates angiogenesis without improving collateral blood flow following hindlimb ischemia in rabbits.

    abstract::This study was designed to test the ability of adenovirus-delivered vascular endothelial growth factor (Ad-VEGF) to stimulate angiogenesis and arteriogenesis in the rabbit hindlimb following the induction of ischemia and to evaluate the functional changes in the collateral circulation. Ten days after the surgical indu...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-003-0694-z

    authors: Hershey JC,Baskin EP,Corcoran HA,Bett A,Dougherty NM,Gilberto DB,Mao X,Thomas KA,Cook JJ

    更新日期:2003-07-01 00:00:00

  • A low prevalence of sarcomeric gene variants in a Chinese cohort with left ventricular non-compaction.

    abstract::Left ventricular non-compaction (LVNC) is genetically heterogeneous. It has been previously shown that LVNC is associated with defects in TAZ, DNTA, LDB3, YWHAE, MIB1, PRDM16, and sarcomeric genes. This study was aimed to investigate sarcomeric gene mutations in a Chinese population with LVNC. From 2004 to 2010, 57 un...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-014-0503-x

    authors: Tian T,Wang J,Wang H,Sun K,Wang Y,Jia L,Zou Y,Hui R,Zhou X,Song L

    更新日期:2015-03-01 00:00:00

  • A large conus artery in patients with hypertrophic cardiomyopathy.

    abstract::We retrospectively analyzed coronary arteriograms in 66 patients with hypertrophic cardiomyopathy (HCM) who underwent coronary arteriography. Four of these patients showed a large conus artery supplying the interventricular septum, and the characteristics of their echocardiograms revealed a marked interventricular sep...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01745868

    authors: Sumimoto T,Hamada M,Ohtani T,Shigematsu Y,Fujiwara Y,Sekiya M,Hiwada K

    更新日期:1992-01-01 00:00:00

  • Expression of vascular endothelial growth factor in human myocardial infarction.

    abstract::To define mechanisms that may influence collateral circulation and angiogenesis, we investigated vascular endothelial growth factor (VEGF) mRNA expression in human hearts. In non-ischemic human hearts, VEGF mRNA was not detected in vessels, but was found in cardiomyocytes. In hearts with myocardial infarction, the int...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01745169

    authors: Shinohara K,Shinohara T,Mochizuki N,Mochizuki Y,Sawa H,Kohya T,Fujita M,Fujioka Y,Kitabatake A,Nagashima K

    更新日期:1996-01-01 00:00:00

  • Does additional coronary artery bypass grafting to aortic valve replacement in elderly patients affect the early and long-term outcome?

    abstract::Early and long-term outcomes in elderly patients who underwent isolated aortic valve replacement (iAVR) are well defined. Conflicting data exist in elderly patients who underwent AVR plus coronary artery bypass grafting (CABG). We sought to evaluate the early and long-term outcomes of combined AVR + CABG in patients o...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01519-6

    authors: Formica F,Mariani S,D'Alessandro S,Singh G,Di Mauro M,Cerrito MG,Messina LA,Scianna S,Papesso F,Sangalli F

    更新日期:2020-04-01 00:00:00

  • The quantitative aspect of photoplethysmography revised.

    abstract::The overall transfer function of a photoplethysmograph (PPG) converting changes in intravascular volume to changes in recorder pen deflection was investigated. The specifications of the apparatus working as a red cell densitometer were assessed in vitro, and it was found that PPG output is a logarithmic function of re...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02128146

    authors: Jespersen LT,Pedersen OL

    更新日期:1986-01-01 00:00:00

  • Aortic dissection is associated with intermittent hypoxia and re-oxygenation.

    abstract::Aortic dissection is a life-threatening cardiovascular disease with high in-hospital mortality. However, the risk factors of aortic dissection have not been fully elucidated. Obstructive sleep apnea (OSA) has been increasingly recognized as an independent cardiovascular risk factor. Among the underlying mechanisms to ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-011-0149-x

    authors: Naito R,Sakakura K,Kasai T,Dohi T,Wada H,Sugawara Y,Kubo N,Yamashita S,Narui K,Ishiwata S,Ohno M,Ako J,Momomura S

    更新日期:2012-05-01 00:00:00

  • Comparison of magnetic wire navigation with the conventional wire technique for percutaneous coronary intervention of chronic total occlusions: a randomised, controlled study.

    abstract::Wire crossing of a chronic total coronary occlusion (CTO) is time consuming and limited by the amount of contrast agent and time of radiation exposure. Magnetic wire navigation (MWN) might accelerate wire crossing by maintaining a coaxial vessel orientation. This study compares MWN with the conventional approach for r...

    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00380-015-0739-0

    authors: Roth C,Berger R,Scherzer S,Krenn L,Gangl C,Dalos D,Delle-Karth G,Neunteufl T

    更新日期:2016-08-01 00:00:00

  • Association between valvuloarterial impedance after transcatheter aortic valve implantation and 2-year mortality in elderly patients with severe symptomatic aortic stenosis: the OCEAN-TAVI registry.

    abstract::Pre-procedural valvuloarterial impedance (Zva) is considered as a useful predictor of mortality in patients diagnosed as having severe aortic stenosis (AS) who undergo transcatheter aortic valve implantation (TAVI). However, the prognostic significance of post-procedural Zva remains unclear. We aimed to evaluate the p...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-01329-2

    authors: Nagura F,Kataoka A,Hara M,Kozuma K,Watanabe Y,Nakashima M,Hioki H,Kawashima H,Nara Y,Shirai S,Tada N,Araki M,Naganuma T,Yamanaka F,Ueno H,Tabata M,Mizutani K,Higashimori A,Takagi K,Yamamoto M,Hayashida K,OCEAN-T

    更新日期:2019-06-01 00:00:00

  • Clinical value of regression of electrocardiographic left ventricular hypertrophy after aortic valve replacement.

    abstract::Electrocardiographic left ventricular hypertrophy (ECG-LVH) gradually regressed after aortic valve replacement (AVR) in patients with severe aortic stenosis. Sokolow-Lyon voltage (SV1 + RV5/6) is possibly the most widely used criterion for ECG-LVH. The aim of this study was to determine whether decrease in Sokolow-Lyo...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-015-0761-2

    authors: Yamabe S,Dohi Y,Higashi A,Kinoshita H,Sada Y,Hidaka T,Kurisu S,Shiode N,Kihara Y,HERO (Hiroshima Heart Study Group) Investigators.

    更新日期:2016-09-01 00:00:00

  • Hydrogen peroxide-induced vascular relaxation in porcine coronary arteries is mediated by Ca2+-activated K+ channels.

    abstract::Hydrogen peroxide (H2O2) elicited concentration-dependent relaxation of endothelium-denuded rings of porcine coronary arteries. The relaxation induced by the H2O2 was markedly attenuated by 10 microM 1H-[1,2,4]oxadiazolo [4,3,a]quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase, or by 100 nM charybdotox...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02750638

    authors: Hayabuchi Y,Nakaya Y,Matsuoka S,Kuroda Y

    更新日期:1998-01-01 00:00:00

  • Mechanotransduction and intracellular signaling mechanisms of stretch-induced remodeling in endothelial cells.

    abstract::We investigated the signaling mechanism of stretch-induced cell remodeling in human umbilical vein endothelial cells (HUVECs). Freshly dissociated HUVECs were cultured on an elastic silicon membrane and subjected to uniaxial cyclic stretch (20% in length, 1 Hz). The cells started to change their morphology as early as...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:

    authors: Sokabe M,Naruse K,Sai S,Yamada T,Kawakami K,Inoue M,Murase K,Miyazu M

    更新日期:1997-01-01 00:00:00

  • The P wave morphology in lead V7 on the synthesized 18-lead ECG is a useful parameter for identifying arrhythmias originating from the right inferior pulmonary vein.

    abstract::Atrial tachyarrhythmias often originate from the superior vena cava (SVC), and right superior (RSPV) and inferior pulmonary veins (RIPV). However, a precise differentiation of those origins is challenging using the standard 12-lead electrocardiogram (ECG) P-wave morphology due to the anatomical proximity. The recently...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01483-1

    authors: Hisazaki K,Miyazaki S,Hasegawa K,Kaseno K,Amaya N,Shiomi Y,Tama N,Ikeda H,Fukuoka Y,Morishita T,Ishida K,Uzui H,Tada H

    更新日期:2020-02-01 00:00:00

  • Distribution of light chains and ATPase activity of myosin in the atrioventricular conducting tissue of bovine heart.

    abstract::The relations of the light chains of myosins of the atria, ventricles, and atrioventricular conducting tissue (specialized myocardial tissue) and the distribution of the light chains of myosin in different regions of the atrioventricular conducting tissue in bovine heart were examined. Two-dimensional gel electrophore...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02059969

    authors: Tamura Y,Orino S,Saijyo Y,Nishimoto T,Nagase N,Mori H

    更新日期:1986-01-01 00:00:00

  • Effects of atorvastatin on inflammation and oxidative stress.

    abstract::Treatment with inhibitors of 3-hydroxyl-3-methylglutaryl coenzyme A reductase (statins) reduces the incidence of cardiovascular events, but it is unclear whether the beneficial effects are mediated solely by their lipid-lowering properties. We therefore investigated whether atorvastatin reduces inflammation and oxidat...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-005-0833-9

    authors: Sugiyama M,Ohashi M,Takase H,Sato K,Ueda R,Dohi Y

    更新日期:2005-07-01 00:00:00

  • Re-elevation of T-wave from day 2 to day 4 after successful percutaneous coronary intervention predicts chronic cardiac systolic dysfunction in patients with first anterior acute myocardial infarction.

    abstract::This study evaluates the clinical significance of re-elevation of T-wave in patients with ST segment elevation acute myocardial infarction (STEMI) undergoing successful percutaneous coronary intervention (PCI). Resolution of ST elevation within 24 h after reperfusion is associated with better outcome. However, little ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-012-0313-y

    authors: Nishizaki F,Tomita H,Yokoyama H,Higuma T,Abe N,Suzuki A,Endo T,Tateyama S,Ishida Y,Osanai T,Okumura K

    更新日期:2013-11-01 00:00:00

  • Increased prevalence of cerebral microbleeds in patients with low left ventricular systolic function.

    abstract::Gradient-echo T2-star (T2*)-weighted magnetic resonance imaging (MRI) is a sensitive method to detect cerebral microbleeds (CMBs). The presence of CMBs was reported to be a marker of future cardiovascular mortality and is associated with various cardiovascular risk factors, use of antithrombotic drugs, and cognitive d...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01503-0

    authors: Watanabe T,Kanzaki Y,Yamauchi Y,Ito T,Nishida Y,Yamamura K,Komori T,Sohmiya K,Hoshiga M

    更新日期:2020-03-01 00:00:00

  • Impact of pharmacological spasm provocation test in patients with a history of syncope.

    abstract::Coronary artery spasm is involved in the pathogenesis of various cardiac disorders. We investigated patients with a history of syncope who underwent elective coronary angiography. We retrospectively analyzed 5781 consecutive patients who had diagnostic or follow-up angiography during a 26-year period. During this peri...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-1046-8

    authors: Sueda S,Kohno H

    更新日期:2018-02-01 00:00:00

  • Serum uric acid levels and long-term outcomes in chronic kidney disease.

    abstract::Hyperuricemia is common in chronic kidney disease (CKD), but data regarding the relationship between serum uric acid levels and the long-term outcomes of CKD patients have been limited. The present study evaluated the associations between baseline serum uric acid levels with mortality and end-stage renal disease (ESRD...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-013-0396-0

    authors: Miyaoka T,Mochizuki T,Takei T,Tsuchiya K,Nitta K

    更新日期:2014-07-01 00:00:00

  • Relationship between blood pressure obtained from the upper arm with a cuff-type sphygmomanometer and central blood pressure measured with a catheter-tipped micromanometer.

    abstract::Recently, the importance of central blood pressure for cardiovascular risk stratification has been emphasized. Accordingly, the differences in peak systolic and bottom diastolic pressures between the ascending aorta and the brachial artery should be clarified. Study subjects consisted of 82 consecutive patients with s...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-007-0998-5

    authors: Ohte N,Saeki T,Miyabe H,Sakata S,Mukai S,Hayano J,Niki K,Sugawara M,Kimura G

    更新日期:2007-11-01 00:00:00

  • Vasoconstrictor effects of endogenous digitalis-like factors extracted from urine of hypertensive patients.

    abstract::The vascular effects of endogenous digitalis-like factors (EDLFs) extracted from the urine of hypertensive patients were investigated in isolated and perfused intermediate auricular and mesenteric arterial preparations of dogs. EDLFs produced a transient vasoconstriction in a dose-related manner in intermediate auricu...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02058788

    authors: Chiba S,Tsukada M,Katsuyama Y,Tada A,Zenda H

    更新日期:1987-01-01 00:00:00

  • Combined effect of nutritional status on long-term outcomes in patients with coronary artery disease undergoing percutaneous coronary intervention.

    abstract::Previous studies have reported the prognostic value of objective nutritional indices such as the Controlling Nutritional Status (CONUT) score, Geriatric Nutritional Risk Index (GNRI) and Prognostic Nutritional Index (PNI). However, the effects of these indices in patients with coronary artery disease (CAD) who have un...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1201-x

    authors: Wada H,Dohi T,Miyauchi K,Endo H,Tsuboi S,Ogita M,Kasai T,Okazaki S,Isoda K,Suwa S,Daida H

    更新日期:2018-12-01 00:00:00