Abstract:
:This study was designed to test the ability of adenovirus-delivered vascular endothelial growth factor (Ad-VEGF) to stimulate angiogenesis and arteriogenesis in the rabbit hindlimb following the induction of ischemia and to evaluate the functional changes in the collateral circulation. Ten days after the surgical induction of hindlimb ischemia, either a control virus (1 x 10(9) pfu) or an adenovirus containing the gene for VEGF(165) (1 x 10(6), 1 x 10(7), 1 x 10(8), or 1 x 10(9) pfu) was administered intramuscularly into the ischemic limb. Thirty days after administration of the adenoviral vectors, skeletal muscle capillary density was assessed and angiography was performed as markers of angiogenesis and arteriogenesis, respectively. Hindlimb blood flow was directly measured and hyperemic tests were performed to evaluate the functional improvements in collateral blood flow. Animals treated with Ad-VEGF at 1 x 10(8) and 1 x 10(9) pfu showed elevated levels of circulating VEGF and dose-dependent hindlimb edema. These doses also led to a robust angiogenic response (i.e., increase in capillary density), but failed to improve collateral blood flow. Consistent with the lack of a functional response, there was no angiographic evidence of enhanced arteriogenesis with any dose of Ad-VEGF. Following the induction of hindlimb ischemia, administration of Ad-VEGF stimulated capillary sprouting (i.e., angiogenesis), but did not increase the growth and development of larger conduit vessels (i.e., arteriogenesis) or improve collateral blood flow. These results support the concept that VEGF may not be expected to have therapeutic utility for the treatment of peripheral or myocardial ischemia.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Hershey JC,Baskin EP,Corcoran HA,Bett A,Dougherty NM,Gilberto DB,Mao X,Thomas KA,Cook JJdoi
10.1007/s00380-003-0694-zsubject
Has Abstractpub_date
2003-07-01 00:00:00pages
142-9issue
3eissn
0910-8327issn
1615-2573journal_volume
18pub_type
杂志文章abstract::We assessed the plaque disruption in 245 consecutive patients with acute coronary syndrome undergoing percutaneous coronary intervention. The plaque fissure was diagnosed with optical coherence tomography, and intravascular ultrasound was used to determine arterial remodeling. Of them, 26 fissures were found in this s...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1271-9
更新日期:2019-03-01 00:00:00
abstract::The progression of cardiac hypertrophy and failure is associated with marked changes in cardiac autonomic innervation, and there are sympathetic-parasympathetic interactions in the regulation of cardiac function. Although the indexes of sympathetic innervation have been found to be depressed with the development of he...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058280
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abstract::Coexistence of hypertension and diabetes mellitus (DM) increases the risk of cardiovascular disease. However, factors associated with future development of DM have not been well elucidated in patients already having essential hypertension. This study prospectively included 168 patients (mean age 41 +/- 7 years, 112 me...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-009-1218-2
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abstract::We herein present a case (72 years, male) with total absence of pulmonary veins (PVs) potentials at the beginning of the first procedure for paroxysmal atrial fibrillation (AF), demonstrating dormant conduction between the left atrium and all PVs revealed by adenosine triphosphate provocation with relation to the inci...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0928-5
更新日期:2017-04-01 00:00:00
abstract::Left ventricular non-compaction (LVNC) is genetically heterogeneous. It has been previously shown that LVNC is associated with defects in TAZ, DNTA, LDB3, YWHAE, MIB1, PRDM16, and sarcomeric genes. This study was aimed to investigate sarcomeric gene mutations in a Chinese population with LVNC. From 2004 to 2010, 57 un...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0503-x
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abstract::Several miRNAs have been demonstrated to be involved in endothelial dysfunction during atherosclerosis (AS). However, the detailed roles and underlying mechanisms of miR-34a in AS-associated endothelial cell apoptosis are far from being addressed. Apolipoprotein E-deficient (ApoE-/-) mice fed with high-fat diet (HFD) ...
journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
abstract::We reported the results of stroke prevention following modified endoscopic procedure for atrial fibrillation. 82 patients underwent modified endoscopic procedure for atrial fibrillation (AF), in whom 47 had paroxysmal, 28 had persistent, and 7 had long-standing atrial fibrillation. CHA2DS2VASC median score was 3 (rang...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0749-y
更新日期:2016-09-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0831-y
更新日期:2005-09-01 00:00:00
abstract::Cardiac systolic (left ventricular ejection fraction) and diastolic (mitral inflow velocity pattern and/or mitral deceleration time) function were reported as predictors of clinical outcome or left ventricular remodeling in patients with acute myocardial infarction (AMI). Recently, a new index (Doppler-derived index c...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-003-0735-7
更新日期:2004-03-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0235-8
更新日期:2013-01-01 00:00:00
abstract::Hyperuricemia is common in chronic kidney disease (CKD), but data regarding the relationship between serum uric acid levels and the long-term outcomes of CKD patients have been limited. The present study evaluated the associations between baseline serum uric acid levels with mortality and end-stage renal disease (ESRD...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0396-0
更新日期:2014-07-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1087-0
更新日期:2009-03-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01745239
更新日期:1994-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2020-11-02 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0251-8
更新日期:2013-05-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0833-9
更新日期:2005-07-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058361
更新日期:1989-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
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journal_title:Heart and vessels
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journal_title:Heart and vessels
pub_type: 杂志文章
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1201-x
更新日期:2018-12-01 00:00:00
abstract::Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0538-z
更新日期:2015-11-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058320
更新日期:1990-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
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