Abstract:
:To define mechanisms that may influence collateral circulation and angiogenesis, we investigated vascular endothelial growth factor (VEGF) mRNA expression in human hearts. In non-ischemic human hearts, VEGF mRNA was not detected in vessels, but was found in cardiomyocytes. In hearts with myocardial infarction, the intensity of the VEGF signal was much higher in smooth muscle cells of arterioles adjacent to necrosis and in infiltrating macrophages than in myocytes around the site of the necrosis. This study suggests that levels of VEGF expression are high in smooth muscle cells and macrophages around infarcted areas after myocardial infarction and that VEGF may play a role in promoting collateral circulation and angiogenesis in human ischemic hearts.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Shinohara K,Shinohara T,Mochizuki N,Mochizuki Y,Sawa H,Kohya T,Fujita M,Fujioka Y,Kitabatake A,Nagashima Kdoi
10.1007/BF01745169subject
Has Abstractpub_date
1996-01-01 00:00:00pages
113-22issue
3eissn
0910-8327issn
1615-2573journal_volume
11pub_type
杂志文章abstract::This study was designed to investigate the effect of low-dose nesiritide on renal function and major cardiac events in patients with acute decompensated heart failure following acute myocardial infarction. Sixty patients were randomized into nesiritide (loading dose 0.5 microg/kg, maintenance dose 0.0075 microg/kg/min...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-009-1171-0
更新日期:2010-03-01 00:00:00
abstract::Intracellular Na(+) ([Na(+)](i)) regulation plays a crucial role in the structural, mechanical, and electrical properties of myocardium. It is assumed that the [Na(+)](i) handling system may differ not only between normal and diseased hearts but also regionally within a heart. To gain new insight concerning disease- a...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-008-1071-8
更新日期:2009-01-01 00:00:00
abstract::Mitral valve morphology after mitral valve surgery affects postoperative intraventricular flow patterns and long-term cardiac performance. We visualized ventricular flow by echocardiography vector flow mapping (VFM) to reveal the impact of different mitral valve procedures. Eleven cases of mechanical mitral valve repl...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-0967-6
更新日期:2017-09-01 00:00:00
abstract::Peripheral artery disease (PAD) is a risk factor for the development of heart failure and mortality. The serum levels of carboxy-terminal telopeptide of type I collagen (I-CTP), a marker for collagen degradation derived from the extracellular matrix of vascular and myocardial tissue, is reportedly a useful marker for ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0858-2
更新日期:2017-02-01 00:00:00
abstract::We report the case of a newborn with an aneurysmal aorto-left ventricular tunnel causing significant paravalvular aortic regurgitation and obstruction of the right ventricular outflow tract (RVOT), coexisting with a bicuspid aortic valve. The coexistence of the two malformations together with the obstruction of the RV...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0445-8
更新日期:2015-01-01 00:00:00
abstract::The aim of this study was to examine the efficacy and safety of this novel epicardial circumferential left atrial ablation (CLAA) with pulmonary vein isolation (PVI) in sustained atrial fibrillation (AF). Thirty domestic pigs were divided equally into 3 groups: AF without ablation (AF group), AF with PVI (PVI group), ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0594-4
更新日期:2015-09-01 00:00:00
abstract::Balneotherapy has been shown to reduce systemic blood pressure in healthy volunteers. Hyperthermia might ameliorate the inflammatory status in heart failure through improving cardiac function. The purpose of this study was to examine the beneficial effects of balneotherapy in patients with chronic heart failure (CHF)....
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-011-0220-7
更新日期:2013-03-01 00:00:00
abstract::It is known that the heart of an athlete has been physiologically adapted by prolonged training. There are a large number of echocardiographic studies which have focused on left ventricular wall thickness and dilatation, but there are few studies concerning right heart function in the athlete's heart. The aim of this ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800200018
更新日期:2002-07-01 00:00:00
abstract::This study aimed to search genes altered in expression after long-term treatment with the angiotensin II type 1 receptor (AT1) antagonist, CV-11974, in volume-overloaded hearts. Arteriovenous shunt was made between the common carotid artery and jugular vein in Japanese White rabbits. Shunt-operated rabbits were random...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800200040
更新日期:2002-11-01 00:00:00
abstract::Although the ultimate cause for the myocardial dysfunction of hypertensive heart disease is still unclear, a crucial role of the myocardial energy metabolism has been suggested. Therefore, the aim of the present study was to investigate whether age-related myocardial dysfunction in hearts of spontaneously hypertensive...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/pl00007270
更新日期:2000-01-01 00:00:00
abstract::To test the therapeutic efficacy of levamisole, 5-week-old DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units of encephalo-myocarditis virus. Levamisole (2.5 mg/kg/per day) was administered intraperitoneally daily, starting simultaneously with the virus inoculation, in experiment I for 14 days, ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02820869
更新日期:1997-01-01 00:00:00
abstract::Pleural effusions following coronary artery bypass grafting (CABG) have been reported in 65%-89% of the cases. The majority of pleural effusions are left-sided, of little significance, and resolve spontaneously. However, a few pleural effusions require specific therapeutics. We report clinical and pleural histologic f...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0930-4
更新日期:2007-01-01 00:00:00
abstract::An excess of thyroid hormone is known to produce cardiac dysfunction and failure, i.e., thyrotoxic heart. We studied the protective effect of coenzyme Q10 (CoQ10) on the thyrotoxic heart in 29 rabbits. A group treated with 1-thyroxine sodium salt (T4; 167 micrograms/kg) for 3 weeks showed marked decreases in the myoca...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058524
更新日期:1987-01-01 00:00:00
abstract::Previous studies assessing vascular responses in nonexercising beds during exercise in patients with chronic heart failure (CHF) have yielded varying results. We proposed that the clinical and hemodynamic severity of heart failure may explain some of the variation. We reasoned that diastolic ventricular interaction (D...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
doi:10.1007/BF03257232
更新日期:1998-01-01 00:00:00
abstract::The clinical and immunological follow-up of a 38-year-old female patient with hypereosinophilic syndrome and classical cardiac involvement, but without demonstrable degranulation of eosinophils and lacking binding of a specific antibody for activated eosinophils, is presented. Instead, the patient demonstrated all the...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058696
更新日期:1990-01-01 00:00:00
abstract::We have theoretically proposed "systolic pressure-volume area" (PVA) as a measure of total mechanical energy generated by ventricular contraction. We then experimentally showed that PVA closely correlates with left ventricular oxygen consumption (Vo2) regardless of ventricular loading conditions in a stable contractil...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058751
更新日期:1991-01-01 00:00:00
abstract::The association between periprocedural hypotension and conscious sedation (CS) during defibrillator implantation remains to be elucidated. The aim of the present study was to compare the occurrence of periprocedural hypotension after CS or local anesthesia (LA) during defibrillator implantation in a retrospective coho...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01462-6
更新日期:2020-01-01 00:00:00
abstract::An unusual case of total occlusion of aorta just distal to the left subclavian artery, bicuspid aortic valve, and occluded left external iliac artery in a 21-year-old man who was admitted with headache and severe hypertension is presented. We wish to report this case because so far there have been none reported with s...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0947-8
更新日期:2007-03-01 00:00:00
abstract::A 53-year-old woman with end-stage renal disease and hypertension, who had received regular artificial hemodialysis for 10 years, has been treated with candesartan in a dose of 8 mg/day against her hypertension, but premature ventricular contractions were often observed during the hemodialysis. QT interval was 445 ms ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0865-3
更新日期:2017-01-01 00:00:00
abstract::A transient left ventricular apical ballooning (so-called "ampulla" or "Takotsubo-shaped" cardiomyopathy) with type I CD36 deficiency is described in a 71-year-old woman. The patient was referred because of chest pain and worsening of dyspnea. Electrocardiogram showed T-wave inversions on the precordal leads, and acut...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-004-0787-3
更新日期:2005-05-01 00:00:00
abstract::Hyperuricemia is common in chronic kidney disease (CKD), but data regarding the relationship between serum uric acid levels and the long-term outcomes of CKD patients have been limited. The present study evaluated the associations between baseline serum uric acid levels with mortality and end-stage renal disease (ESRD...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0396-0
更新日期:2014-07-01 00:00:00
abstract::Based on the unique property of fluorine-18 fluorodeoxyglucose, localization and follow-up of hypermetabolic processes is possible with positron emission tomography (PET). The dual-modality PET/computed tomography (CT) systems provide intrinsically fused morphologic and functional data in a single examination. We repo...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-004-0808-2
更新日期:2005-07-01 00:00:00
abstract::Normoxic isolated rat hearts were perfused for 30 or 60 min with Krebs-Henseleit bicarbonate buffer (KHB) (in which the Pi concentration was adjusted to 0, 1.2, 2.4, or 10 mM) in both the presence and the absence of glucose as exogenous substrate. Functional performance and coronary flow were monitored throughout the ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058588
更新日期:1988-01-01 00:00:00
abstract::Coronary artery spasm is involved in the pathogenesis of various cardiac disorders. We investigated patients with a history of syncope who underwent elective coronary angiography. We retrospectively analyzed 5781 consecutive patients who had diagnostic or follow-up angiography during a 26-year period. During this peri...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1046-8
更新日期:2018-02-01 00:00:00
abstract::Hyperuricemia is known to be associated with adverse outcomes in cardiovascular intensive care patients, but its mechanisms are unknown. A total of 569 emergency department patients were prospectively analyzed and assigned to intensive care (ICU group, n = 431) or other departments (n = 138). Uric acid (UA) levels wer...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01608-x
更新日期:2020-10-01 00:00:00
abstract::The purpose of this study was to investigate the use of hepatocyte growth factor as a biochemical marker for acute myocardial infarction. Several biochemical markers are used for noninvasive detection of acute myocardial infarction. However, hepatocyte growth factor has not been used previously for this purpose. We me...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02766790
更新日期:1997-01-01 00:00:00
abstract::Although the suction force that moves blood into the left ventricle during early diastole is thought to play an important role in diastolic function, there have been a few studies of this phenomenon in normal children. Suction force is measured as the intraventricular pressure difference (IVPD) and intraventricular pr...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1239-9
更新日期:2019-02-01 00:00:00
abstract::Renin-angiotensin system (RAS) inhibitors may be useful in preventing the occurrence of paroxysmal atrial fibrillation (PAF). However, evaluation of such effect is difficult because many PAF episodes are asymptomatic and not all episodes are detected by intermittent electrocardiographic monitoring. A pacemaker has bee...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-015-0627-7
更新日期:2016-03-01 00:00:00
abstract::Thoracic outlet syndrome (TOS) is caused by compression of peripheral nerves and vascular structures along their course through the upper thoracic aperture to the axilla. The aim of our study was to analyze long-term outcomes of different treatments stratified by symptom severity. We performed a retrospective analysis...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0112-2
更新日期:2011-11-01 00:00:00
abstract::The subendocardial side of myocardium makes a major contribution to left ventricular (LV) contraction and is very susceptible to ischemia. In this study we sought to quantify regional wall motion during low-dose dobutamine stress echocardiography (DSE) by using the myocardial velocity gradient (MVG) derived from tissu...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800070042
更新日期:2000-01-01 00:00:00