Expression of vascular endothelial growth factor in human myocardial infarction.

Abstract:

:To define mechanisms that may influence collateral circulation and angiogenesis, we investigated vascular endothelial growth factor (VEGF) mRNA expression in human hearts. In non-ischemic human hearts, VEGF mRNA was not detected in vessels, but was found in cardiomyocytes. In hearts with myocardial infarction, the intensity of the VEGF signal was much higher in smooth muscle cells of arterioles adjacent to necrosis and in infiltrating macrophages than in myocytes around the site of the necrosis. This study suggests that levels of VEGF expression are high in smooth muscle cells and macrophages around infarcted areas after myocardial infarction and that VEGF may play a role in promoting collateral circulation and angiogenesis in human ischemic hearts.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Shinohara K,Shinohara T,Mochizuki N,Mochizuki Y,Sawa H,Kohya T,Fujita M,Fujioka Y,Kitabatake A,Nagashima K

doi

10.1007/BF01745169

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

113-22

issue

3

eissn

0910-8327

issn

1615-2573

journal_volume

11

pub_type

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