Abstract:
:Mechanical alternans (MA) is frequently observed in patients with heart failure, and is a predictor of cardiac events. However, there have been controversies regarding the conditions and mechanisms of MA. To clarify heart rate-dependent contractile properties related to MA, we performed incremental right atrial pacing in 17 idiopathic dilated cardiomyopathy (DCM) patients and in six control patients. The maximal increase in left ventricular dP/dt during pacing-induced tachycardia was assessed as the force gain in the force-frequency relationship (FG-FFR), and the maximal increase in left ventricular dP/dt of the first post-pacing beats was examined as the force gain in poststimulation potentiation (FG-PSP). As a result, MA was induced in 9 DCM patients (DCM MA(+)) but not in the other 8 DCM patients (DCM MA(-)), and not in any of the control patients. DCM MA(+) had significantly lower FG-FFR (34.7 ± 40.9 vs 159.4 ± 103.9 mmHg/s, P = 0.0091) and higher FG-PSP (500.0 ± 96.8 vs 321.9 ± 94.9 mmHg/s, P = 0.0017), and accordingly a wider gap between FG-PSP and FG-FFR (465.3 ± 119.4 vs 162.5 ± 123.6 mmHg/s, P = 0.0001) than DCM MA(-) patients. These characteristics of DCM MA(+) showed clear contrasts to those of the control patients. In conclusion, MA is caused with an impaired force-frequency relationship despite significant poststimulation potentiation, suggesting that MA reflects ineffective utilization of the potentiated intrinsic force during tachycardia.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Kashimura T,Kodama M,Tanaka K,Sonoda K,Watanabe S,Ohno Y,Tomita M,Obata H,Mitsuma W,Ito M,Hirono S,Hanawa H,Aizawa Ydoi
10.1007/s00380-012-0251-8subject
Has Abstractpub_date
2013-05-01 00:00:00pages
336-44issue
3eissn
0910-8327issn
1615-2573journal_volume
28pub_type
杂志文章abstract::Chronic kidney disease (CKD) is well known to be associated with an increased incidence of coronary artery disease (CAD). Diabetes mellitus (DM) and hypertension (HTN), both of which are traditional risk factors for CAD, are the two most common causes of CKD. However, the influence of CKD on coronary atherosclerosis i...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-01334-5
更新日期:2019-07-01 00:00:00
abstract::We assessed the plaque disruption in 245 consecutive patients with acute coronary syndrome undergoing percutaneous coronary intervention. The plaque fissure was diagnosed with optical coherence tomography, and intravascular ultrasound was used to determine arterial remodeling. Of them, 26 fissures were found in this s...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1271-9
更新日期:2019-03-01 00:00:00
abstract::Primary myocardial involvement is common in systemic sclerosis (SSc). We evaluated the atrial and ventricular electromechanical characteristics by using tissue Doppler echocardiography in SSc patients with subclinical cardiac involvement. Twenty-seven consecutive patients (24 women; mean age +/- SD 49.9 +/- 11.3 years...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-009-1197-3
更新日期:2010-05-01 00:00:00
abstract::In early systole, before the effects of reflected waves from the periphery become significant, the following equation applies: PA - PO = rho cu (1) where PA and PO are the instantaneous and end-diastolic pressures in the ascending aorta, rho the density of blood, c the velocity of the pulse wave in the aorta, and u th...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02073644
更新日期:1987-01-01 00:00:00
abstract::Females have increase in-hospital mortality and poorer outcomes following coronary artery bypass grafting (CABG). Biological differences in the reactivity of the graft conduits to circulating catecholamine may contribute to this sex difference. This study examined sex differences in the vasoconstrictor responses of in...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01508-9
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Predictors of left ventricular ejection fraction (LVEF) improvement after transcatheter aortic valve replacement (TAVR) in patients with a preoperative reduced LVEF are limited. OBJECTIVES:This study aimed to investigate the relationship between preprocedural valuvuloarterial impedance (ZVa), which represen...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01591-3
更新日期:2020-09-01 00:00:00
abstract::Low levels of Soluble TNF-related apoptosis induced ligand (sTRAIL) seem to be related to worse prognosis after an acute coronary syndrome. PostConditioning (PostCond) may protect the heart from reperfusion injury. We sought to evaluate the impact of PostCond on sTRAIL in relationship to infarct size (area under the c...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-016-0851-9
更新日期:2017-02-01 00:00:00
abstract::Coronary slow flow (CSF) is characterized by delayed opacification of coronary arteries in the absence epicardial occlusive disease. QT duration and dispersion have been reported to be longer in patients with CSF. ACE inhibitors may improve CSF through positive effects on endothelial function. The study included 32 pa...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0058-4
更新日期:2011-07-01 00:00:00
abstract::Atrial tachyarrhythmias often originate from the superior vena cava (SVC), and right superior (RSPV) and inferior pulmonary veins (RIPV). However, a precise differentiation of those origins is challenging using the standard 12-lead electrocardiogram (ECG) P-wave morphology due to the anatomical proximity. The recently...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01483-1
更新日期:2020-02-01 00:00:00
abstract::The relations of the light chains of myosins of the atria, ventricles, and atrioventricular conducting tissue (specialized myocardial tissue) and the distribution of the light chains of myosin in different regions of the atrioventricular conducting tissue in bovine heart were examined. Two-dimensional gel electrophore...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02059969
更新日期:1986-01-01 00:00:00
abstract::We recently reported that preoperative endothelial dysfunction [i.e., reactive hyperemia index (RHI) ≤ 1.64] predicted short-term postoperative adverse events in patients undergoing cardiovascular surgery. However, the relationship between preoperative RHI and long-term cardiovascular risk in these patients is unclear...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1248-8
更新日期:2019-02-01 00:00:00
abstract::In a mass chest computed tomography (CT) screening using a mobile helical CT unit, we measured the aortic diameter at three segments to confirm standard values and also attempted to detect any asymptomatic aortic aneurysms. The population screened in the present study consisted of 6971 subjects (3847 men and 3124 wome...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s380-002-8315-1
更新日期:2002-01-01 00:00:00
abstract::High levels of serum phosphate are associated with calcification of human smooth muscle cells (HSMCs). We investigated whether inhibition of protein kinase A (PKA) and mitogen-activated protein kinase (MAPK) signals [p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK)] can reduce inorga...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0427-x
更新日期:2014-09-01 00:00:00
abstract::This study was designed to investigate the effect of low-dose nesiritide on renal function and major cardiac events in patients with acute decompensated heart failure following acute myocardial infarction. Sixty patients were randomized into nesiritide (loading dose 0.5 microg/kg, maintenance dose 0.0075 microg/kg/min...
journal_title:Heart and vessels
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00380-009-1171-0
更新日期:2010-03-01 00:00:00
abstract::It is well known that silent myocardial ischemia (SMI) often complicates patients with cerebral infarction and that stroke patients often die of ischemic heart disease. Therefore, it is considered important to treat myocardial ischemia in stroke patients. This study investigated SMI complicating Japanese patients with...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0210-9
更新日期:2013-01-01 00:00:00
abstract::The subendocardial side of myocardium makes a major contribution to left ventricular (LV) contraction and is very susceptible to ischemia. In this study we sought to quantify regional wall motion during low-dose dobutamine stress echocardiography (DSE) by using the myocardial velocity gradient (MVG) derived from tissu...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s003800070042
更新日期:2000-01-01 00:00:00
abstract::Cardiac systolic (left ventricular ejection fraction) and diastolic (mitral inflow velocity pattern and/or mitral deceleration time) function were reported as predictors of clinical outcome or left ventricular remodeling in patients with acute myocardial infarction (AMI). Recently, a new index (Doppler-derived index c...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-003-0735-7
更新日期:2004-03-01 00:00:00
abstract::Sex-related factors play an important role in the pathophysiology of heart failure (HF). However, trends in sex-related differences in hospital management for HF are not clear. We identified patients hospitalized for HF through a nationwide database (National Health Insurance in Taiwan), containing 722,272 subjects fr...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0299-5
更新日期:2013-11-01 00:00:00
abstract::T cells are involved in the pathogenesis of atherosclerosis. We aimed to search for any association between the peripheral T-cell activities and atherogenic risk factors in healthy subjects. Fifty male volunteers (age 22.0 +/- 2.4 years) were enrolled. No subject had any chronic disease or was under any drug treatment...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-005-0893-x
更新日期:2006-07-01 00:00:00
abstract::Aortic dissection is a life-threatening cardiovascular disease with high in-hospital mortality. However, the risk factors of aortic dissection have not been fully elucidated. Obstructive sleep apnea (OSA) has been increasingly recognized as an independent cardiovascular risk factor. Among the underlying mechanisms to ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0149-x
更新日期:2012-05-01 00:00:00
abstract::Scanning electron microscopy was used to compare the shape, size, and connection of left ventricular (LV) myocytes between spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) at 3, 8, 15, 35, and 63 weeks of age. For either strain at each age, five rats were studied, in which LV myocytes consisted of a c...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02481739
更新日期:1999-01-01 00:00:00
abstract::The use of cine-computed tomography scanning is described in evaluating cardiac function in a patient with a bileaflet mitral valve prosthesis (St. Jude medical valve) and in a second patient with both mitral and aortic bileaflet prostheses. Both biventricular and prosthesis function were assessed successfully. ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058316
更新日期:1987-01-01 00:00:00
abstract::Although drug-eluting stents (DES) for percutaneous coronary intervention (PCI) have dramatically reduced the incidence of in-stent restenosis, their deployment for large-size coronary lesions is still controversial because of problems such as late in-stent thrombosis and late catch-up in DES. We aimed to evaluate the...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0655-3
更新日期:2016-05-01 00:00:00
abstract::The purpose of this study was to examine factors influencing readmission to hospital in patients with heart failure. This multicenter, retrospective cohort study analyzed 197 heart failure patients admitted to the research cooperation facilities between January 2017 and November 2017. We defined the readmission group ...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-019-01500-3
更新日期:2020-03-01 00:00:00
abstract::Although drug-eluting stents have improved clinical outcomes, percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) remains a challenging procedure in terms of thrombus management. A new-generation P2Y12 receptor inhibitor, prasugrel, provides more rapid and potent antiplatelet action compared wit...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01686-x
更新日期:2020-09-09 00:00:00
abstract::While recent guidelines for the treatment of acute heart failure syndromes (AHFS) recommend pharmacotherapy with vasodilators in patients without excessively low blood pressure (BP), few reports have compared the relative efficiency of vasodilators on hemodynamics in AHFS patients. The present study aimed to assess th...
journal_title:Heart and vessels
pub_type: 临床试验,杂志文章
doi:10.1007/s00380-012-0252-7
更新日期:2013-05-01 00:00:00
abstract::Little evidence exists regarding the need for a reduction in postoperative heart rate after repair of type A acute aortic dissection. This single-center retrospective study was conducted to determine if lower heart rate during the early postoperative phase is associated with improved long-term outcomes after surgery f...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0486-7
更新日期:2015-05-01 00:00:00
abstract::In order to clarify the pathogenesis of acute myocardial infarction (MI) in hearts with normal coronary arteries, infarct size, and the extent of contraction band necrosis (CBN), coagulation necrosis, and hemorrhage were quantitatively examined using an image analyzer in 5 autopsy cases of MI with normal or nearly nor...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02301880
更新日期:1990-01-01 00:00:00
abstract::Subclavian artery stenosis can cause a flow reversal-so-called steal-not only in the ipsilateral vertebral artery, but also in the internal mammary artery in patients with a history of coronary-artery bypass grafting. Subclavian artery stenosis is also associated with peripheral artery disease elsewhere. We report a n...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0821-2
更新日期:2016-11-01 00:00:00
abstract::Liver cirrhosis (LC), which may result in hepatic failure or cancer, has been reported in patients after Fontan procedure. The purpose of this study was to clarify the frequency and histological characteristics of LC, and to evaluate the risk factors and serological markers of LC with Fontan circulation. Retrospective...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0743-4
更新日期:2016-09-01 00:00:00