Abstract:
:The hydrostatic pressure (perfusion pressure) of the isovolumic isolated perfused rat heart regulated the hydrodynamics (water movement) of the myocardium. An abrupt (10 s) decrease in hydrostatic pressure caused an immediate decrease in oxygen consumption, left ventricular developed pressure, and wall thickness. Wall thickness was determined by two-dimensional echocardiography. When the perfusion pressure was again returned to the control values (140 cm H2O) oxygen consumption, developed pressure, and wall thickness returned to control values within 10-30 s. An abrupt decrease in perfusion pressure also caused an immediate decrease in both extracellular and intracellular water in the heart as determined by H-1 NMR (nuclear magnetic resonance) with the shift reagent Dy(TTHA)3- (Dysprosium triethylene tetramine-hexaacetate). Similar findings were obtained using K(CoEDTA) (potassium cobalt ethylenediaminetetraacetate) utilized as an extracellular marker. With a decrease in intracellular water in the heart, there was a concurrent decrease in intracellular calcium.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Watters TA,Bouchard A,Wu ST,Parmley WW,Wikman-Coffelt Jdoi
10.1007/BF02058424subject
Has Abstractpub_date
1988-01-01 00:00:00pages
128-35issue
3eissn
0910-8327issn
1615-2573journal_volume
4pub_type
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