Abstract:
:Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type fatty acid-binding protein (uL-FABP) for early detection of AKI in these patients, comparing their performance with another group of cardiac surgery patients. Biomarkers were measured in 193 patients, 12 h after intervention. In the ROC analysis, AUC for KIM-1, NGAL and L-FABP was 0.713, 0.958 and 0.642, respectively, in the coronary angiography group, and 0.716, 0.916 and 0.743 in the cardiac surgery group. Urinary KIM-1 12 h after intervention is predictive of AKI in adult patients undergoing coronary angiography, but NGAL shows higher sensitivity and specificity. L-FABP provides inferior discrimination for AKI than KIM-1 or NGAL in contrast to its performance after cardiac surgery. This is the first study showing the predictive capacity of KIM-1 for AKI after coronary angiography. Further studies are still needed to answer relevant questions about the clinical utility of biomarkers for AKI in different clinical settings.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Torregrosa I,Montoliu C,Urios A,Andrés-Costa MJ,Giménez-Garzó C,Juan I,Puchades MJ,Blasco ML,Carratalá A,Sanjuán R,Miguel Adoi
10.1007/s00380-014-0538-zsubject
Has Abstractpub_date
2015-11-01 00:00:00pages
703-11issue
6eissn
0910-8327issn
1615-2573pii
10.1007/s00380-014-0538-zjournal_volume
30pub_type
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