Abstract:
:Adenosine constricted 37 of 58 isolated and perfused monkey coronary arteries, whereas it dilated dog coronary arteries in all cases. The vasoconstriction induced by 0.1-10 micrograms (0.37-37.4 nmol) of adenosine was examined, since adenosine in large doses produced tachyphylaxis. The adenosine-induced vasoconstriction was significantly attenuated by diltiazem (100 micrograms [0.24 mumol]), although it was not affected by aminophylline (100 micrograms [0.23 mumol]), phentolamine (100 micrograms [0.36 mumol]), or methysergide (10 micrograms [28 nmol]. Forty-minute treatment with indomethacin (5 x 10(-6) mol/l) completely prevented the adenosine-induced vasoconstriction, but it did not significantly inhibit vasoconstriction induced by KCl (3 mg [40 mumol])- or norepinephrine (NE, 0.1 micrograms [0.59 nmol]). These results suggest that: (1) adenosine constricts monkey coronary arteries by increasing Ca2+ influx across the smooth muscle cell membrane; (2) cyclooxygenase products may be involved in the adenosine-induced vasoconstriction; (3) adenosine receptors may not be involved in the vasoconstriction.
journal_name
Heart Vesselsjournal_title
Heart and vesselsauthors
Nakane T,Chiba Sdoi
10.1007/BF02058320subject
Has Abstractpub_date
1990-01-01 00:00:00pages
71-5issue
2eissn
0910-8327issn
1615-2573journal_volume
5pub_type
杂志文章abstract::Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0538-z
更新日期:2015-11-01 00:00:00
abstract::The aim of this study was to evaluate the relation between aortic artery distensibility, expressed by pulse pressure (PP) and autonomic nervous system function expressed by heart rate variability (HRV), among elders. During 2009, 469 individuals (50 % males, mean age 75 ± 6 years old), permanent inhabitants of Ikaria ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-012-0267-0
更新日期:2013-07-01 00:00:00
abstract::We examined mRNA expression of the clock genes (Per1, Per2, and Bmal1) and PAI-1 (plasminogen activator inhibitor-1) after aldosterone treatment every 4 h up to 48 h in H9c2 cardiomyoblasts by reverse transcription-polymerase chain reaction. To block the MR (mineralocorticoid receptor), the MR antagonist, spironolacto...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0968-3
更新日期:2007-07-01 00:00:00
abstract::The objectives of the study were to evaluate the impact of aortic angulation (AA) on success of transcatheter aortic valve replacement (TAVR) with a new generation self-expandable prosthesis (Medtronic Evolut R®). Specific anatomical conditions, such as for example the presence of a horizontal aorta with elevated AA, ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01436-8
更新日期:2019-12-01 00:00:00
abstract::Although cisplatin is indispensable for the chemotherapy treatment of many malignancies, cisplatin-associated thrombosis is attracting increasing attention. However, experience of primary percutaneous coronary intervention (PCI) and intravascular ultrasound imaging (IVUS) for coronary thrombosis, possibly due to cispl...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-011-0222-5
更新日期:2012-11-01 00:00:00
abstract::A 65-year-old man was admitted with chest pain. A diagnosis of spastic angina was made because of symptoms of recurrent anginal attacks associated with ST-segment elevations in the electrocardiogram. A selective coronary arteriogram revealed a 90% diameter narrowing of the proximal left anterior descending coronary ar...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058361
更新日期:1989-01-01 00:00:00
abstract::Between 1987 and 1989, twenty-two patients who received combined heart-lung transplantation were autopsied at La Pitie Salpetriere Hospital in Paris. With the exception of two recipients who survived for 2 months and 4 months, respectively, the majority of the patients died in the early postoperative period (the mean ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02125099
更新日期:1991-01-01 00:00:00
abstract::We investigated the therapeutic principles and strategies to treat sustained ventricular tachycardia (SVT) as five leading medical institutions in the Tokyo area and summarized the present situation of SVT treatment in Japan. Catheter ablation (ABL) has been almost established to be effective in idiopathic ventricular...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Sleep-disordered breathing (SDB) has a critical association with mortality and morbidity of patients with chronic heart failure (CHF). Troponin T is a marker of ongoing myocardial damage and predicts adverse clinical outcomes in patients with CHF. Carnitine plays an important role in the utilization of fatty acids in ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-014-0479-6
更新日期:2015-05-01 00:00:00
abstract::Previous studies have reported the prognostic value of objective nutritional indices such as the Controlling Nutritional Status (CONUT) score, Geriatric Nutritional Risk Index (GNRI) and Prognostic Nutritional Index (PNI). However, the effects of these indices in patients with coronary artery disease (CAD) who have un...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1201-x
更新日期:2018-12-01 00:00:00
abstract::We have theoretically proposed "systolic pressure-volume area" (PVA) as a measure of total mechanical energy generated by ventricular contraction. We then experimentally showed that PVA closely correlates with left ventricular oxygen consumption (Vo2) regardless of ventricular loading conditions in a stable contractil...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058751
更新日期:1991-01-01 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) with severe diastolic dysfunction is a major cause of heart failure and sudden cardiac death (SCD) associated with lethal arrhythmia. Although various risk factors for cardiac events have been reported in HCM patients, previous studies have reported that some HCM patients exhibit eith...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01440-y
更新日期:2019-12-01 00:00:00
abstract::MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression. It seems that microRNA-21 (miR-21) and Visfatin, a novel adipocytokine, play roles in inflammation and atherosclerosis. The aim of this study was to investigate the association of miR-21 with Visfatin, inflammation, atherosclerosis and acute c...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0913-z
更新日期:2017-05-01 00:00:00
abstract::Ischemic cardiomyopathy complicated by severe mitral regurgitation (MR) has a poor prognosis. In such cases, whether mitral valve repair for MR improves the prognosis of survival remains unclear. In this study, 50 patients diagnosed with ischemic cardiomyopathy at our hospital between August 1991 and August 1996 were ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-004-0763-y
更新日期:2004-07-01 00:00:00
abstract::To assess left ventricular diastolic properties in response to dynamic exercise, mitral inflow velocity integrals were measured by pulsed-wave Doppler echocardiography in ten patients with myocardial infarction and in ten normal subjects, and simultaneous left ventricular pressure was obtained with micromanometry in t...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::This study aimed to investigate the combined efficacy in prediction of major adverse cardiac events (MACE) by coronary regional physiological indices including coronary flow reserve (CFR) or fractional flow reserve (FFR) and high-sensitivity cardiac troponin-I (hs-cTnI) or N-terminal pro brain natriuretic peptide (NT-...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-018-1260-z
更新日期:2019-03-01 00:00:00
abstract::The coronary flow velocity reserve (CFVR), a measure of endothelial function in coronary circulation, can be measured semi-invasively in the left anterior descending coronary artery by using stress transesophageal echocardiography (TEE). During the same stress TEE, aortic distensibility indices (elastic modulus [E(p)]...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0939-8
更新日期:2007-03-01 00:00:00
abstract::Dilated cardiomyopathy (DCM) is a common primary myocardial disease leading to congestive heart failure, arrhythmia and sudden cardiac death. Increasing studies demonstrate substantial genetic determinants for DCM. Nevertheless, DCM is of substantial genetic heterogeneity, and the genetic basis for DCM in most patient...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-017-1110-4
更新日期:2018-07-01 00:00:00
abstract::Transcatheter MitraClip repair is a new tool for the management of severe mitral regurgitation in patients at very high risk for conventional surgery. Aim of our study was reporting one-year clinical outcomes in candidates to MitraClip procedures, divided into three groups according to the cardiovascular medicine hear...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-015-0772-z
更新日期:2016-10-01 00:00:00
abstract::Peripheral artery disease (PAD) is a risk factor for the development of heart failure and mortality. The serum levels of carboxy-terminal telopeptide of type I collagen (I-CTP), a marker for collagen degradation derived from the extracellular matrix of vascular and myocardial tissue, is reportedly a useful marker for ...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-016-0858-2
更新日期:2017-02-01 00:00:00
abstract::Although the number of pregnancies in women with cardiac disease is increasing worldwide, there are few data concerning their clinical characteristics and peripartum outcomes. Using the Diagnosis Procedure Combination database between 2008 and 2014 in Japan, we retrospectively identified pregnant women who underwent h...
journal_title:Heart and vessels
pub_type: 杂志文章,多中心研究
doi:10.1007/s00380-018-1137-1
更新日期:2018-08-01 00:00:00
abstract::We analyzed whether smoking was associated with major adverse cardiovascular events (MACE) and the progression of coronary atherosclerosis as assessed by coronary computed tomography angiography (CCTA) as screening for coronary artery disease (CAD). We enrolled 443 patients who had all undergone CCTA and either were c...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-020-01727-5
更新日期:2020-11-27 00:00:00
abstract::The inotropic effects of 5-hydroxytryptamine (5-HT) on mammalian heart muscles were investigated. 5-HT (10(-8)-10(-3)M) produced increases in the contractile tension of atrial and ventricular muscles isolated from guinea pigs, Japanese monkeys, and humans, but not in rat heart preparations. The maximum percent increas...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01744594
更新日期:1996-01-01 00:00:00
abstract::The presence of myocardial interstitial edema in acute myocarditis (AM) leads to thickening of the ventricular wall, and conduction disturbances, such as complete atrioventricular block (CAV), also frequently develop. This study was undertaken in order to clarify the relationship between conduction disturbances and my...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-006-0922-4
更新日期:2006-11-01 00:00:00
abstract::The overall transfer function of a photoplethysmograph (PPG) converting changes in intravascular volume to changes in recorder pen deflection was investigated. The specifications of the apparatus working as a red cell densitometer were assessed in vitro, and it was found that PPG output is a logarithmic function of re...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02128146
更新日期:1986-01-01 00:00:00
abstract::Hyperuricemia is common in chronic kidney disease (CKD), but data regarding the relationship between serum uric acid levels and the long-term outcomes of CKD patients have been limited. The present study evaluated the associations between baseline serum uric acid levels with mortality and end-stage renal disease (ESRD...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-013-0396-0
更新日期:2014-07-01 00:00:00
abstract::Early and long-term outcomes in elderly patients who underwent isolated aortic valve replacement (iAVR) are well defined. Conflicting data exist in elderly patients who underwent AVR plus coronary artery bypass grafting (CABG). We sought to evaluate the early and long-term outcomes of combined AVR + CABG in patients o...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-019-01519-6
更新日期:2020-04-01 00:00:00
abstract::Thoracic outlet syndrome (TOS) is caused by compression of peripheral nerves and vascular structures along their course through the upper thoracic aperture to the axilla. The aim of our study was to analyze long-term outcomes of different treatments stratified by symptom severity. We performed a retrospective analysis...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/s00380-010-0112-2
更新日期:2011-11-01 00:00:00
abstract::The distribution and structure of lymphatic and blood capillaries in the rabbit heart conduction system were investigated by transmission electron microscopy. The sinuatrial node, atrioventricular node, and atrioventricular bundle possessed a rich network of lymphatic capillaries, which were situated not only at the p...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF02058423
更新日期:1988-01-01 00:00:00
abstract::To define mechanisms that may influence collateral circulation and angiogenesis, we investigated vascular endothelial growth factor (VEGF) mRNA expression in human hearts. In non-ischemic human hearts, VEGF mRNA was not detected in vessels, but was found in cardiomyocytes. In hearts with myocardial infarction, the int...
journal_title:Heart and vessels
pub_type: 杂志文章
doi:10.1007/BF01745169
更新日期:1996-01-01 00:00:00