Aldosterone induces circadian gene expression of clock genes in H9c2 cardiomyoblasts.

Abstract:

:We examined mRNA expression of the clock genes (Per1, Per2, and Bmal1) and PAI-1 (plasminogen activator inhibitor-1) after aldosterone treatment every 4 h up to 48 h in H9c2 cardiomyoblasts by reverse transcription-polymerase chain reaction. To block the MR (mineralocorticoid receptor), the MR antagonist, spironolactone, was added to the medium 1 h before aldosterone treatment. Aldosterone induced an initial increase and rhythmic expression of Per1, while spironolactone attenuated the acute increase in Per1 mRNA induced by aldosterone. On the other hand, aldosterone did not increase the Per2 mRNA in the acute phase, but thereafter induced a rhythmic expression of Per2. Aldosterone also induced rhythmic expression of Bmal1, a positive element of the clock genes. The rhythm of Bmal1 mRNA was anti-phase of that of Per2 mRNA. Aldosterone induced an acute increase in PAI-1 mRNA, but did not induce rhythmic expression of PAI-1. The present study demonstrated first that aldosterone regulates expression of the clock genes Per1, Per2, and Bmal1, and increases PAI-1 expression in H9c2 cardiomyoblasts. Second, an acute increase in Per1 mRNA after aldosterone treatment is mediated through MR. Third, clock genes are not related to PAI-1 expression in H9c2 cardiomyoblasts.

journal_name

Heart Vessels

journal_title

Heart and vessels

authors

Tanaka K,Ashizawa N,Kawano H,Sato O,Seto S,Nishihara E,Terazono H,Isomoto S,Shinohara K,Yano K

doi

10.1007/s00380-006-0968-3

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

254-60

issue

4

eissn

0910-8327

issn

1615-2573

journal_volume

22

pub_type

杂志文章
  • Systolic pressure-volume area (PVA) as the energy of contraction in Starling's law of the heart.

    abstract::We have theoretically proposed "systolic pressure-volume area" (PVA) as a measure of total mechanical energy generated by ventricular contraction. We then experimentally showed that PVA closely correlates with left ventricular oxygen consumption (Vo2) regardless of ventricular loading conditions in a stable contractil...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02058751

    authors: Suga H,Goto Y,Futaki S,Kawaguchi O,Yaku H,Hata K,Takasago T

    更新日期:1991-01-01 00:00:00

  • Total absence of pulmonary vein potentials in a patient with paroxysmal atrial fibrillation: was it really isolated?

    abstract::We herein present a case (72 years, male) with total absence of pulmonary veins (PVs) potentials at the beginning of the first procedure for paroxysmal atrial fibrillation (AF), demonstrating dormant conduction between the left atrium and all PVs revealed by adenosine triphosphate provocation with relation to the inci...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-016-0928-5

    authors: Yokoyama K,Yamashita S,Tokutake K,Narui R,Kato M,Tanigawa S,Tokuda M,Inada K,Matsuo S,Shibayama K,Miyanaga S,Yoshimura M,Yamane T

    更新日期:2017-04-01 00:00:00

  • Oxidative stress versus antioxidant defenses in patients with acute myocardial infarction.

    abstract::Acute myocardial infarction (AMI) is a highly dynamic event, which is associated with increasing production of reactive oxygen species (ROS). The imbalance between ROS production and antioxidant defenses leads to the condition known as oxidative stress. The most widely recognized effect of increasing oxidative stress ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-010-0029-9

    authors: Bagatini MD,Martins CC,Battisti V,Gasparetto D,da Rosa CS,Spanevello RM,Ahmed M,Schmatz R,Schetinger MR,Morsch VM

    更新日期:2011-01-01 00:00:00

  • Taurine prevents beta-glycerophosphate-induced calcification in cultured rat vascular smooth muscle cells.

    abstract::Vascular calcification is an ectopic calcification that commonly occurs in atherosclerosis. Because taurine was previously shown to protect against cardiovascular diseases, the effect of taurine on vascular calcification was evaluated in calcified vascular smooth muscle cells (VSMCs) of rat in vitro in the present stu...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-003-0744-6

    authors: Li J,Zhang B,Huang Z,Wang S,Tang C,Du J

    更新日期:2004-05-01 00:00:00

  • Development of suction force during early diastole from the left atrium to the left ventricle in infants, children, and adolescents.

    abstract::Although the suction force that moves blood into the left ventricle during early diastole is thought to play an important role in diastolic function, there have been a few studies of this phenomenon in normal children. Suction force is measured as the intraventricular pressure difference (IVPD) and intraventricular pr...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-018-1239-9

    authors: Takahashi K,Nii M,Takigiku K,Toyono M,Iwashima S,Inoue N,Tanaka N,Matsui K,Shigemitsu S,Yamada M,Kobayashi M,Yazaki K,Itatani K,Shimizu T

    更新日期:2019-02-01 00:00:00

  • Changes in coagulation and fibrinolytic parameters caused by extracorporeal circulation.

    abstract::During cardiopulmonary bypass (CPB) mechanical stress and the contact of blood with artificial surfaces lead to the activation of pro- and anticoagulant systems and the complement cascade, and to changes in cellular components. This phenomenon causes the "postperfusion-syndrome", with leukocytosis, increased capillary...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01747190

    authors: Grossmann R,Babin-Ebell J,Misoph M,Schwender S,Neukam K,Hickethier T,Elert O,Keller F

    更新日期:1996-01-01 00:00:00

  • An unusual case of multiple aortic abnormalities: total occlusion of aortic arch, left external iliac artery, and bicuspid aortic valve in a 21-year-old man.

    abstract::An unusual case of total occlusion of aorta just distal to the left subclavian artery, bicuspid aortic valve, and occluded left external iliac artery in a 21-year-old man who was admitted with headache and severe hypertension is presented. We wish to report this case because so far there have been none reported with s...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-006-0947-8

    authors: Tanindi A,Tavil Y,Mutluay R,Taktak H,Cengel A

    更新日期:2007-03-01 00:00:00

  • Prognostic impact of mitral L-wave in patients with hypertrophic cardiomyopathy without risk factors for sudden cardiac death.

    abstract::Hypertrophic cardiomyopathy (HCM) with severe diastolic dysfunction is a major cause of heart failure and sudden cardiac death (SCD) associated with lethal arrhythmia. Although various risk factors for cardiac events have been reported in HCM patients, previous studies have reported that some HCM patients exhibit eith...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01440-y

    authors: Sugiura Y,Morimoto R,Aoki S,Yamaguchi S,Haga T,Kuwayama T,Yokoi T,Hiraiwa H,Kondo T,Watanabe N,Kano N,Fukaya K,Sawamura A,Okumura T,Murohara T

    更新日期:2019-12-01 00:00:00

  • Body mass index is associated with prognosis in Japanese elderly patients with atrial fibrillation: an observational study from the outpatient clinic.

    abstract::The relationship between body mass index (BMI) and the prognosis of elderly patients with atrial fibrillation (AF) is unknown. We aimed to examine the association of body weight with the clinical outcomes among Japanese elderly patients with a history of documented AF. This observational study of AF patients from an o...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-015-0765-y

    authors: Yanagisawa S,Inden Y,Yoshida N,Kato H,Miyoshi-Fujii A,Mizutani Y,Ito T,Kamikubo Y,Kanzaki Y,Hirai M,Murohara T

    更新日期:2016-09-01 00:00:00

  • The distribution of calcified nodule and plaque rupture in patients with peripheral artery disease: an intravascular ultrasound analysis.

    abstract::In addition to plaque rupture (PR), calcified nodule (CN) may also have the potential to develop into arterial thrombus in the peripheral arteries. This study evaluated the distribution of plaque ruptures and calcified nodules in the peripheral arteries and their impact on the outcome of endovascular therapy (EVT). Co...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-0984-5

    authors: Horimatsu T,Fujii K,Fukunaga M,Miki K,Nishimura M,Naito Y,Shibuya M,Imanaka T,Kawai K,Tamaru H,Sumiyoshi A,Saita T,Masuyama T,Ishihara M

    更新日期:2017-10-01 00:00:00

  • U-shaped association of central pulse pressure with long-term prognosis after ST-segment elevation myocardial infarction.

    abstract::The relationship between central pulse pressure (CPP) measured at the time of primary percutaneous coronary intervention (PPCI) and long-term prognosis after ST-segment elevation myocardial infarction (STEMI) has not been investigated. CPP measurements were performed in 1348 patients with STEMI (327 women; mean age 62...

    journal_title:Heart and vessels

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00380-019-01344-x

    authors: Ndrepepa G,Cassese S,Kufner S,Xhepa E,Fusaro M,Laugwitz KL,Schunkert H,Kastrati A

    更新日期:2019-07-01 00:00:00

  • The 5352 A allele of the pro-inflammatory caspase-1 gene predicts late-acquired stent malapposition in STEMI patients treated with sirolimus stents.

    abstract::Late-acquired stent malapposition (LASM) is a common finding after sirolimus-eluting stent (SES) implantation and may be the cause for late stent thrombosis. Inflammation may play a pivotal role in LASM just as it plays in stent restenosis. We have therefore investigated seven polymorphisms involved in inflammatory pr...

    journal_title:Heart and vessels

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00380-010-0046-8

    authors: Bergheanu SC,Pons D,van der Hoeven BL,Liem SS,Siegerink B,Schalij MJ,van der Bom JG,Jukema JW

    更新日期:2011-05-01 00:00:00

  • Aberrant right coronary artery occlusion during the percutaneous pulmonary trunk stenting in a patient with tetralogy of Fallot.

    abstract::Aberrant coronary arteries are frequently observed in patients presenting with Fallot's tetralogy (TOF). Before the complete surgical repair of the TOF, the percutaneously performed pulmonary trunk (PT) angioplasty is often performed in order to temporarily increase the pulmonary circulation, thus increasing the pulmo...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-007-1023-8

    authors: Perret X,Bonvini RF,Aggoun Y,Verin V

    更新日期:2008-03-01 00:00:00

  • Castration modifies aortic vasoreactivity and serum fatty acids in a sucrose-fed rat model of metabolic syndrome.

    abstract::Levels of testosterone and estradiol influence the incidence of cardiovascular diseases: generally, estrogens in females are protective before menopause; coronaropathies, hypertension, and dyslipidemias in normal men are more frequent at comparable ages. We investigated the modulation by castration of in vitro vasorea...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-008-1098-x

    authors: Perez I,El Hafidi M,Carvajal K,Baños G

    更新日期:2009-03-01 00:00:00

  • Successful treatment of intraoperative pulmonary tumor embolism from renal cell carcinoma.

    abstract::During left nephrectomy in a 35-year-old woman with a left renal cell carcinoma extending into the inferior vena cava (IVC) and right atrium, cardiac arrest occurred. Immediate transesophageal echocardiography demonstrated that the event was caused by a pulmonary tumor embolism. Emergent cardiopulmonary bypass (CPB) w...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF02767048

    authors: Nagasaka S,Taniguchi S,Kobayashi S,Kawata T,Mizuguchi K,Hirao Y,Kitamura S

    更新日期:1997-01-01 00:00:00

  • Myocardial deformational adaptations to different forms of training: a real-time three-dimensional speckle tracking echocardiographic study.

    abstract::The hemodynamic load due to physical activity leads to structural and functional cardiac adaptations known as "Athlete's heart". We aimed to compare myocardial performance in different groups of trained athletes by means of 3D echocardiography and 3D speckle tracking echocardiography (3D-STE). 66 athletes [26 strength...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-014-0520-9

    authors: Monte IP,Mangiafico S,Buccheri S,Bottari VE,Lavanco V,Arcidiacono AA,Leggio S,Deste W,Tamburino C

    更新日期:2015-05-01 00:00:00

  • Aneurysmal aorto-left ventricular tunnel causing right ventricular outflow tract obstruction, associated with bicuspid aortic valve.

    abstract::We report the case of a newborn with an aneurysmal aorto-left ventricular tunnel causing significant paravalvular aortic regurgitation and obstruction of the right ventricular outflow tract (RVOT), coexisting with a bicuspid aortic valve. The coexistence of the two malformations together with the obstruction of the RV...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-013-0445-8

    authors: Toganel R,Benedek T,Suteu C,Benedek I

    更新日期:2015-01-01 00:00:00

  • Brief myocardial ischemia affects free radical generating and scavenging systems in dogs.

    abstract::This study examined whether brief repeated myocardial ischemia altered free radical generating and scavenging activity in a dog model. In dogs preconditioned with four 5-min left anterior descending coronary artery (LAD) occlusions and reperfusions, we examined transcardiac changes in both the function of neutrophils,...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01744795

    authors: Hoshida S,Kuzuya T,Yamashita N,Oe H,Fuji H,Hori M,Tada M,Kamada T

    更新日期:1993-01-01 00:00:00

  • Points to note from indications for heart transplantation to post-heart transplant care: from the care of patients with refractory heart failure and overseas heart transplantation.

    abstract::To examine important points surrounding the indications for heart transplantation (HTX) to care after HTX, we reviewed 22 patients with refractory heart failure aged less than 60 years who had been observed for the past 6 years. Sixteen patients had dilated cardiomyopathy; 1, dilated hypertrophic cardiomyopathy; 3, re...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:

    authors: Nunoda S,Kurosawa R,Kogashi K,Yamagishi S,Mitsui F,Funabashi W

    更新日期:1997-01-01 00:00:00

  • Serum uric acid levels and long-term outcomes in chronic kidney disease.

    abstract::Hyperuricemia is common in chronic kidney disease (CKD), but data regarding the relationship between serum uric acid levels and the long-term outcomes of CKD patients have been limited. The present study evaluated the associations between baseline serum uric acid levels with mortality and end-stage renal disease (ESRD...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-013-0396-0

    authors: Miyaoka T,Mochizuki T,Takei T,Tsuchiya K,Nitta K

    更新日期:2014-07-01 00:00:00

  • Influence of mild cognitive impairment on activities of daily living in patients with cardiovascular disease.

    abstract::Activities of daily living (ADL) are maintained in patients with mild cognitive impairment (MCI), but, in patients with cardiovascular disease, ADL may have already declined. MCI combined with cardiac disease may accentuate the decline of ADL in these patients. Because the relationship between MCI and ADL in patients ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01437-7

    authors: Ishihara K,Izawa KP,Kitamura M,Shimogai T,Kanejima Y,Morisawa T,Shimizu I

    更新日期:2019-12-01 00:00:00

  • Correction to: High-intensity aerobic interval training can lead to improvement in skeletal muscle power among in-hospital patients with advanced heart failure.

    abstract::In the original publication of the article, the unit of hand in Fig. 2 was wrongly given as "N/kg" instead of "kg". ...

    journal_title:Heart and vessels

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s00380-018-1132-6

    authors: Taya M,Amiya E,Hatano M,Maki H,Nitta D,Saito A,Tsuji M,Hosoya Y,Minatsuki S,Nakayama A,Fujiwara T,Konishi Y,Yokota K,Watanabe M,Morita H,Haga N,Komuro I

    更新日期:2018-07-01 00:00:00

  • Diverse inotropic effects of 5-hydroxytryptamine in heart muscles of various mammalian species.

    abstract::The inotropic effects of 5-hydroxytryptamine (5-HT) on mammalian heart muscles were investigated. 5-HT (10(-8)-10(-3)M) produced increases in the contractile tension of atrial and ventricular muscles isolated from guinea pigs, Japanese monkeys, and humans, but not in rat heart preparations. The maximum percent increas...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/BF01744594

    authors: Zaizen H,Imanishi S,Nasu M,Arita M

    更新日期:1996-01-01 00:00:00

  • Surgical management of a uterine leiomyoma extending through the inferior vena cava into the right heart.

    abstract::We present a case of a 38-year-old woman with intravenous leiomyomatosis originating from the uterus involving the right ventricle, right atrium, inferior vena cava, and iliac veins. Tumors in the heart and the inferior vena cava were removed using cardiopulmonary bypass and circulatory arrest; 10 days after the cardi...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s003800200049

    authors: Gaudino M,Spatuzza P,Snider F,Luciani N,Cina G,Possati G

    更新日期:2002-12-01 00:00:00

  • Gallic acid induces vascular smooth muscle cell death via hydroxyl radical production.

    abstract::In the present study, we investigated whether gallic acid (GA) can induce death in cultured vascular smooth muscle cells (VSMCs), and whether production of the hydroxyl radical (.OH) is involved in the process of GA action. GA killed cultured VSMCs from rat aorta, in a dosc- and time-dependent manner. Cytoplasmic shri...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s003800070038

    authors: Qiu X,Takemura G,Koshiji M,Hayakawa Y,Kanoh M,Maruyama R,Ohno Y,Minatoguchi S,Akao S,Fukuda K,Fujiwara T,Fujiwara H

    更新日期:2000-01-01 00:00:00

  • Parameters of arterial function and structure in adult patients after coarctation repair.

    abstract::Regardless of a successful operation, patients with coarctation of aorta (CoAo) are exposed to the risk of hypertension and a propensity to vascular and end-organ damage. The aim of this study is to evaluate the influence of residual aorta stenosis as well as the age at the operation on the parameters of arterial func...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-010-0063-7

    authors: Trojnarska O,Mizia-Stec K,Gabriel M,Szczepaniak-Chicheł L,Katarzyńska-Szymańska A,Grajek S,Tykarski A,Gąsior Z,Kramer L

    更新日期:2011-07-01 00:00:00

  • Real-world outcomes of rivaroxaban treatment in elderly Japanese patients with nonvalvular atrial fibrillation.

    abstract::Direct oral anticoagulants (DOACs), such as rivaroxaban, reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (NVAF). However, it is still unclear whether the stroke reduction benefit outweighs the bleeding risk in elderly Japanese patients with NVAF. The Xarelto Post-Author...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-019-01487-x

    authors: Kitazono T,Ikeda T,Ogawa S,Nakagawara J,Minematsu K,Miyamoto S,Murakawa Y,Cavaliere M,Hayashi Y,Kidani Y,Okayama Y,Sunaya T,Sato S,Yamanaka S

    更新日期:2020-03-01 00:00:00

  • Simultaneous echocardiographic evaluation of coronary flow velocity reserve and aortic distensibility indices in hypertension.

    abstract::The coronary flow velocity reserve (CFVR), a measure of endothelial function in coronary circulation, can be measured semi-invasively in the left anterior descending coronary artery by using stress transesophageal echocardiography (TEE). During the same stress TEE, aortic distensibility indices (elastic modulus [E(p)]...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-006-0939-8

    authors: Nemes A,Forster T,Csanády M

    更新日期:2007-03-01 00:00:00

  • Diffuse fibromuscular dysplasia successfully treated with scoring balloon angioplasty in a 3-year-old boy.

    abstract::In children, up to 10% of the cases of arterial hypertension may be caused by a renovascular disease. The etiology of this renovascular disease is most of the time due to a fibromuscular dysplasia (FMD), which causes a noninflammatory intimal-medial fibroplasia leading to luminal compromise. Percutaneous transluminal ...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-009-1147-0

    authors: Bonvini RF,Rastan A,Sixt S,Righini M,Hofstetter R,Zeller T

    更新日期:2009-11-01 00:00:00

  • The relationship between systolic vector flow mapping parameters and left ventricular cardiac function in healthy dogs.

    abstract::Vector flow mapping (VFM) is a novel echocardiographic technology that shows blood flow vectors and vortexes, enabled the hydrokinetic evaluation of hemodynamics within the left ventricle. VFM provides several unique parameters: circulation, vorticity, vortex area, and energy loss. The present study aims to reveal a r...

    journal_title:Heart and vessels

    pub_type: 杂志文章

    doi:10.1007/s00380-017-1093-1

    authors: Goya S,Wada T,Shimada K,Hirao D,Tanaka R

    更新日期:2018-05-01 00:00:00