Effects of phenobarbital on early intellectual and behavioral development: a concordant twin case study.

Abstract:

:A Monozygotic twin pair had febrile seizures, only one was treated with phenobarbital from 17-30 months of age. Standard intellectual and behavioral assessments were conducted during Treatment (30 months of age), and Post-Treatment (32, 41, 48, 66 months of age). Both twins showed normal global intelligence at all assessments, however, the phenobarbital twin scored lower at all assessments. Differences in specific abilities were also seen during Post-Treatment. When phenobarbital was withdrawn, the treated twin's behavior showed immediate improvement. This experience suggests that early phenobarbital treatment may affect global intelligence through the preschool period, but that the effect is not severe. Phenobarbital also may adversely affect behavior, although the effect disappears with termination of the drug.

authors

Byrne JM,Camfield PR,Clark-Touesnard M,Hondas BJ

doi

10.1080/01688638708405059

subject

Has Abstract

pub_date

1987-08-01 00:00:00

pages

393-8

issue

4

eissn

1380-3395

issn

1744-411X

journal_volume

9

pub_type

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