Effects of triazolam and ethanol on proactive interference: evidence for an impairment in retrieval inhibition.

Abstract:

:The effects of two memory-impairing drugs, ethanol and triazolam, on proactive interference (PI) in memory were studied. Following ingestion of either one of these drugs or a placebo, subjects studied an A-B list (e.g., BEE-WASP) of paired associates, followed by an A-C list (e.g., BEE-HONEY) on the interference trial, and a D-E list (e.g., KING-QUEEN) followed by an A-C list on the control trial. A PI effect was found in the data, such that subjects produced fewer correct second list targets on the interference trial than on the control trial. Neither ethanol nor triazolam was found to influence the size of the PI effect. However, both drugs were found to increase B intrusions on the test of the A-C list, to impair subjects' ability to produce more than one studied response for each cue word, and to impair the subjective experience of retrieved memory information. These data suggest that ethanol and triazolam impair an inhibitory process that normally operates as one component of intentional retrieval, playing an important role in the suppression of unwanted information during a memory task.

authors

Lombardi WJ,Sirocco KY,Andreason PJ,George DT

doi

10.1080/01688639708403755

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

698-712

issue

5

eissn

1380-3395

issn

1744-411X

journal_volume

19

pub_type

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