Abstract:
:Atrophy of specific, regional, and generalized brain structures occurs as a result of the Alzheimer's disease (AD) process. Comparing AD patients with histopathological confirmation of the disease at autopsy to those without autopsy but who were clinically diagnosed using the same antemortem criteria will provide further evidence of the utility and accuracy of neuropsychological assessments at the time of diagnosis, as well as the efficacy of quantitative magnetic resonance imaging (qMRI) in demonstrating gross neuropathological changes associated with the disease. The Cache County Study of Aging provides a unique opportunity to determine how closely AD subjects with only the clinical diagnosis match similarly diagnosed AD subjects but with postmortem confirmation of the disease. qMRI volumes of various brain structures, as well as neuropsychological outcome measures from an expanded battery, were obtained in 31 autopsy-confirmed AD subjects and 45 clinically diagnosed AD subjects. Of the various qMRI variables examined, only total temporal lobe volume was different, where those with postmortem confirmation had reduced volume. No significant differences between the two groups were found with any of the neuropsychological outcome measures. These findings confirm the similarity in neuroimaging and neuropsychological assessment findings between those with just the clinical diagnosis of AD and those with an autopsy-confirmed diagnosis in the moderate-to-severe stage of the disease at the time of diagnosis.
journal_name
J Clin Exp Neuropsycholjournal_title
Journal of clinical and experimental neuropsychologyauthors
Fearing MA,Bigler ED,Norton M,Tschanz JA,Hulette C,Leslie C,Welsh-Bohmer K,Cache County Investigators.doi
10.1080/13803390600826579subject
Has Abstractpub_date
2007-07-01 00:00:00pages
553-60issue
5eissn
1380-3395issn
1744-411Xpii
779506168journal_volume
29pub_type
杂志文章abstract::The development of a set of everyday, nonverbal, digitized sounds for use in auditory confrontation naming applications is described. Normative data are reported for 120 sounds of varying lengths representing a wide variety of acoustic events such as sounds produced by animals, people, musical instruments, tools, sign...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1076/jcen.22.6.830.949
更新日期:2000-12-01 00:00:00
abstract::A current model proposes that memory consists of two functionally separate systems that have different neurological substrates. Declarative memory appears to be dependent on the diencephalic medial temporal lobe system whereas some speculate that the basal ganglia may be a neurological substrate for procedural memory....
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639008400978
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abstract::Huntington disease (HD) is a neurodegenerative disease associated with cognitive, motor, and psychiatric deterioration over time. Although there is currently no cure for HD, there has been a surge of clinical trials available to patients with HD over the past 5 years. However, cognitive measures have generally been la...
journal_title:Journal of clinical and experimental neuropsychology
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journal_title:Journal of clinical and experimental neuropsychology
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abstract::Subjective recall of symptoms among nonlitigants with closed-head and back injuries and non-injured participants with high and low levels of life stressors was evaluated. All participants completed a demographic questionnaire, the Brief Symptom Inventory, and a symptom checklist. Recall of symptoms by participants wit...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 临床试验,杂志文章
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abstract::Reconstructing the temporal order of events is a crucial part of episodic memory. The temporal dimension, however, is often discarded in clinical settings, and measurements of true temporal aspects of episodic memory are scarce. The present study assessed temporal memory in stroke patients and in age- and education-ma...
journal_title:Journal of clinical and experimental neuropsychology
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abstract::Recovery in 60 patients with a closed-head injury (CHI) in the first year posttrauma was assessed repeatedly with a series of attention tests. A matched group of healthy subjects was tested at the same intervals to allow us to control for practice effects. The results of a multilevel analysis for longitudinal data sho...
journal_title:Journal of clinical and experimental neuropsychology
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journal_title:Journal of clinical and experimental neuropsychology
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journal_title:Journal of clinical and experimental neuropsychology
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journal_title:Journal of clinical and experimental neuropsychology
pub_type: 临床试验,杂志文章
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abstract::Proficient, nonnative English-speaking neurosurgery candidates are assessed for language function in English. In order to understand whether it is necessary to also assess native-language function, we examined the influence of native language on the bilingual language network of early, proficient bilinguals using func...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
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journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章,meta分析
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journal_title:Journal of clinical and experimental neuropsychology
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journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639408402680
更新日期:1994-10-01 00:00:00
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journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
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journal_title:Journal of clinical and experimental neuropsychology
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journal_title:Journal of clinical and experimental neuropsychology
pub_type: 传,历史文章,杂志文章,评审
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journal_title:Journal of clinical and experimental neuropsychology
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journal_title:Journal of clinical and experimental neuropsychology
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journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章,多中心研究
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journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
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更新日期:1995-08-01 00:00:00
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journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
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更新日期:1995-04-01 00:00:00
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journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:Journal of clinical and experimental neuropsychology
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journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639308402610
更新日期:1993-11-01 00:00:00
abstract::Declarative and procedural learning were assessed in patients with probable Alzheimer's Disease (AD) and major depression, patients with AD and no depression, patients with major depression but no dementia, and a group of age-comparable nondemented and nondepressed normal controls. AD patients showed significant defic...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
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