Wechsler Intelligence Scale profiles, the cholinergic system, and Alzheimer's disease.

Abstract:

:Forty-one patients with putative Alzheimer's Disease (AD) were evaluated to determine the diagnostic utility of a profile of Wechsler Adult Intelligence Scale (WAIS) subtests which has been proposed by Fuld (1984) to identify cholinergic dysfunction. Only nine (21.9%) of these patients had positive Wechsler profiles. Half (n = 21) of the AD patients had been given the WAIS, and the other half (n = 20) the Wechsler Adult Intelligence Scale-Revised (WAIS-R). Positive profiles occurred more often in the AD subgroup given the WAIS-R, but this difference was not statistically significant. Specificity of the formula was evaluated using Wechsler results of 42 older normals and 30 patients who were being evaluated for dementia but who did not have AD. One of the 42 normals (2.4%) and five of the patient controls (16.7%) showed a positive Wechsler profile. Because of the Fuld formula's low sensitivity, a negative Wechsler profile cannot be used to help rule out AD. Although specificity of the formula is high, the diagnostic value of a positive Wechsler profile is modest even under the most favorable AD baserate conditions.

authors

Filley CM,Kobayashi J,Heaton RK

doi

10.1080/01688638708405359

subject

Has Abstract

pub_date

1987-04-01 00:00:00

pages

180-6

issue

2

eissn

1380-3395

issn

1744-411X

journal_volume

9

pub_type

杂志文章
  • Stability of intraindividual variability as a marker of neurologic dysfunction in relapsing remitting multiple sclerosis.

    abstract:BACKGROUND:Impairments in information processing speed are common in multiple sclerosis (MS), with affected individuals demonstrating slower responses and more intraindividual variability (IIV) in their performance on timed tasks. Evidence suggesting that IIV provides novel information about cognitive deficits in MS is...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2014.903898

    authors: Wojtowicz MA,Ishigami Y,Mazerolle EL,Fisk JD

    更新日期:2014-01-01 00:00:00

  • Relationship between the apolipoprotein E gene and headache following sports-related concussion.

    abstract:INTRODUCTION:Headache is one of the most commonly reported and longest lasting symptoms that concussed athletes report, yet the etiology of headache symptoms following concussion is not entirely clear. The purpose of this study was to determine whether the e4 allele of the apolipoprotein E (APOE) gene influences the pr...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2016.1177491

    authors: Merritt VC,Ukueberuwa DM,Arnett PA

    更新日期:2016-11-01 00:00:00

  • Memory deficit after closed head injury.

    abstract::This paper reviews research concerning impairment of memory during the early and late stages of recovery from closed-head injury (CHI). Posttraumatic and retrograde amnesia are discussed, including direct measurement, rate of forgetting and evoked potential correlates. Studies of residual memory deficit in survivors o...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章,评审

    doi:10.1080/01688639008400960

    authors: Levin HS

    更新日期:1990-01-01 00:00:00

  • Neuropsychological functioning of adults with attention deficit hyperactivity disorder.

    abstract::The neuropsychological functioning of adults with Attention Deficit Hyperactivity Disorder (ADHD) was compared to that of healthy controls and individuals with mild psychiatric disorders including attentional complaints. Thirty adults in each group were examined on the Conners' Continuous Performance Test (CPT) and me...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1076/1380-3395(200002)22:1;1-8;FT115

    authors: Walker AJ,Shores EA,Trollor JN,Lee T,Sachdev PS

    更新日期:2000-02-01 00:00:00

  • The relation between ethnicity and cognistat performance in males seeking substance use disorder treatment.

    abstract::This study examined the relation between ethnicity and results obtained during standard administration of the Cognistat, a screening measure of cognitive functioning, in a sample of male veterans seeking substance use disorder treatment (n = 312). Results indicated that screening items for the Naming, Calculation, and...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803390490919173

    authors: Schrimsher GW,O'Bryant SE,Parker JD,Burke RS

    更新日期:2005-10-01 00:00:00

  • Choosing appropriate comparison group participants in studies of veterans: Characteristics of orthopedically injured and uninjured Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn veterans.

    abstract:INTRODUCTION:Research addressing deployment-related traumatic brain injury (TBI) is fairly complex due to a high prevalence of comorbid conditions, multiple exposures, and the lack of acute medical records. Therefore, there is a need for a well-defined, matching comparison group. This study compared deployment-related ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2016.1167172

    authors: Troyanskaya M,Pastorek NJ,Scheibel RS,Petersen NJ,Walder A,Henson HK,Levin HS

    更新日期:2016-09-01 00:00:00

  • Neurocognitive deficits in cocaine users: a quantitative review of the evidence.

    abstract::Studies on the neurocognitive effects of cocaine abuse are equivocal with respect to the specific types of deficits observed, although the vast majority of studies indicate that at least some deficits in certain broad functions such as attention, learning and memory, executive functions, and response speed exist. All ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803390490515694

    authors: Jovanovski D,Erb S,Zakzanis KK

    更新日期:2005-02-01 00:00:00

  • Self-reported everyday memory and depression in patients with multiple sclerosis.

    abstract::Depression and memory difficulties are among the most common complaints voiced by patients with multiple sclerosis (MS). Nevertheless, little is known about how depression might affect patients' perceptions of their memory difficulties. The present investigation was designed to explore this issue. Results supported a ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1076/jcen.26.2.200.28081

    authors: Bruce JM,Arnett PA

    更新日期:2004-04-01 00:00:00

  • Executive function in Parkinson's disease: set-shifting or set-maintenance?

    abstract::In order to distinguish impairment in set-shifting in Parkinson's disease (PD) from inability to inhibit distraction by stimuli that compete for attention, 18 nondemented patients with idiopathic PD and 13 normal controls equated for age and education, were administered the Odd-Man Out (OMO) test and the Stroop Color-...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688639308402562

    authors: Richards M,Cote LJ,Stern Y

    更新日期:1993-03-01 00:00:00

  • HIV+ men and women show different performance patterns on procedural learning tasks.

    abstract::The literature suggests that nondeclarative, or nonconscious, learning might be impaired among HIV-seropositive (HIV+) individuals compared with HIV-seronegative (HIV-) matched control groups, but these studies have included relatively few women. We administered measures of motor skill and probabilistic learning, task...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2010.493150

    authors: Martin E,Gonzalez R,Vassileva J,Maki P

    更新日期:2011-01-01 00:00:00

  • Spatial memory following temporal lobe resection.

    abstract::The present study sought a clearer understanding of spatial memory function consequent to temporal lobe resection, and, in particular, of spatial memory function with respect to two- as well as three-dimensional frames of reference. Relative to a group of 15 control participants, a group of 15 epilepsy patients with r...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803390500434359

    authors: Diaz-Asper CM,Dopkins S,Potolicchio SJ Jr,Caputy A

    更新日期:2006-11-01 00:00:00

  • Visuoconstructive performance and regional cerebral glucose metabolism in Alzheimer's disease.

    abstract::The drawings of Alzheimer's disease (AD) patients and elderly control subjects were rated on a number of specific performance scales, such as attention to configuration, attention to detail, and stimulus boundedness. AD patients showed significantly poorer performance than controls on most drawing scales, and the draw...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688639108401088

    authors: Ober BA,Jagust WJ,Koss E,Delis DC,Friedland RP

    更新日期:1991-09-01 00:00:00

  • Identifying instruments to quantify financial management skills in adults with acquired cognitive impairments.

    abstract:INTRODUCTION:Financial management skills-that is, the skills needed to handle personal finances such as banking and paying bills-are essential to a person's autonomy, independence, and community living. To date, no comprehensive review of financial management skills instruments exists, making it difficult for clinician...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章,评审

    doi:10.1080/13803395.2015.1087468

    authors: Engel L,Bar Y,Beaton DE,Green RE,Dawson DR

    更新日期:2016-01-01 00:00:00

  • Memory deficits in Wilson's disease: a response to Lang.

    abstract::Lang (1989) suggested that patients with Wilson's disease do not have memory deficits, unless they suffer from severe neurologic impairment. Results from three recent studies conflict with this view. The interaction of neurologic and cognitive deficits in Wilson's disease is discussed. ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 评论,杂志文章

    doi:10.1080/01688639108401049

    authors: Medalia A

    更新日期:1991-03-01 00:00:00

  • The transience and nature of cognitive impairments in transient global amnesia: a meta-analysis.

    abstract::Transient global amnesia (TGA) is a clinical syndrome characterized by the sudden onset of severe amnesia without concomitant focal neurological symptoms. This meta-analysis of the cognitive characteristics of TGA addressed two main issues. First, we examined the hypothesis that the acute phase of TGA is associated wi...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章,meta分析

    doi:10.1080/13803390801955193

    authors: Jäger T,Bäzner H,Kliegel M,Szabo K,Hennerici MG

    更新日期:2009-01-01 00:00:00

  • Measurement equivalence of neuropsychological tests across education levels in older adults.

    abstract:OBJECTIVE:The objective was to determine whether neuropsychological tests provide an equivalent measure of the same psychological constructs in older adults with low versus higher levels of education. METHOD:Confirmatory factor analysis was used to evaluate the fit of a three-factor model (Verbal Ability, Visuospatial...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2014.967661

    authors: Brewster PW,Tuokko H,MacDonald SW

    更新日期:2014-01-01 00:00:00

  • About the power for detecting severe impairment in older adults with the Faces test from Wechsler Memory Scale-III: simply guess and save face.

    abstract::The Faces test from Wechsler Memory Scale-III is a widely used instrument for detecting impairment in visual memory. However, the degree to which this test actually achieves its purpose may be seriously hampered by error due to guessing. This problem becomes all the more pronounced among elderly clients, where impairm...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1076/jcen.25.3.376.13804

    authors: Boaz L

    更新日期:2003-05-01 00:00:00

  • The influence of "State" related factors on focused attention following whiplash associated disorder.

    abstract::The modified Stroop task was presented to 48 patients with a Whiplash Associated Disorder (WAD) and 48 healthy matched controls to investigate possible attentional impairments in relation to state related factors (headache, neck pain, fatigue, tension and state-anxiety). It was expected that performance on the Stroop ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1076/jcen.24.4.471.1042

    authors: Blokhorst M,Swinkels M,Lof O,Lousberg R,Zilvold G

    更新日期:2002-06-01 00:00:00

  • Selective impairments in spatial memory after ischaemic stroke.

    abstract::There is evidence that object-location memory consists of three separate processes, that is, positional memory, binding of objects to locations, and a possible integration mechanism. A group of 26 patients with lesions following ischaemic stroke was studied to find evidence for selective impairments in these three pro...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1076/jcen.24.1.115.967

    authors: Kessels RP,de Haan EH,Kappelle LJ,Postma A

    更新日期:2002-02-01 00:00:00

  • Deficits of attention after closed-head injury: slowness only?

    abstract::The performance of a group of 60 severely closed-head-injured patients in the subacute stage of recovery on a series of tests addressing focused, divided, and sustained attention, and supervisory attentional control was compared to the performance of a matched group of 60 healthy controls. Patients performed significa...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1080/01688639608408298

    authors: Spikman JM,van Zomeren AH,Deelman BG

    更新日期:1996-10-01 00:00:00

  • The blindside: impact of monocular occlusion on spatial attention.

    abstract::Monocular occlusion has been posited to reduce activation of the contralateral hemisphere ("Sprague effect"), thus inducing a contralateral spatial bias (toward the viewing eye). Healthy right-handed participants bisected horizontal lines during monocular eye viewing. Although subjects tended to deviate away from the ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2013.770824

    authors: Burtis DB,Williamson JB,Mishra M,Heilman KM

    更新日期:2013-01-01 00:00:00

  • Affective and cognitive theory of mind in Alzheimer's disease: The role of executive functions.

    abstract::Introduction: Although there are plenty of studies on affective or cognitive theory of mind (ToM) in Alzheimer's Disease (AD), few have investigated both these dimensions and even fewer have examined the ability to identify an emotion from context in relation to the executive function deficit. Thus, the purpose of thi...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2020.1726293

    authors: Chainay H,Gaubert F

    更新日期:2020-05-01 00:00:00

  • Associations between executive functions and problematic social networking sites use.

    abstract:BACKGROUND:Research on problematic internet use has greatly increased over the last decade. Although there were many studies related to problematic social networking sites (SNS) use, there is limited empirical research yet focused on exploring the relationship between problematic SNS use and Executive Functions (EF). ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2020.1798358

    authors: Aydın O,Obuća F,Boz C,Ünal-Aydın P

    更新日期:2020-08-01 00:00:00

  • Memory for faces in epileptic children before and after brain surgery.

    abstract::Memory for pairs of unfamiliar children's faces was investigated in 29 children and adolescents suffering from left (LTLE) or right (RTLE) temporal-lobe epilepsy, before and after temporal-lobe surgery. Both immediate and delayed memory were tested. Before surgery, RTLE subjects performed worse than either LTLE subjec...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688639408402670

    authors: Beardsworth ED,Zaidel DW

    更新日期:1994-08-01 00:00:00

  • Inhibition and facilitation in schizotypy.

    abstract::Participants scoring high and low on a schizotypy scale (n=18 in each group) switched between naming words and naming colors in a Stroop task in congruent, neutral, and incongruent conditions. The findings were that, while being slower and less accurate overall than low schizotypes, the high schizotypy group did not d...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803390701336866

    authors: Cimino M,Haywood M

    更新日期:2008-02-01 00:00:00

  • Some aspects of memory disorders clearly distinguish dementia of the Alzheimer's type from depressive pseudo-dementia.

    abstract::Two groups of patients affected by mild dementia of the Alzheimer's type (n = 42) or by depressive pseudo-dementia (n = 26) were given a modified version of the Rey's Auditory Verbal Learning Test. The two groups were roughly matched for overall level of cognitive impairment. The main purpose of the research was to de...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688639408402617

    authors: Gainotti G,Marra C

    更新日期:1994-02-01 00:00:00

  • Traumatic brain injury and alcohol/substance abuse: A Bayesian meta-analysis comparing the outcomes of people with and without a history of abuse.

    abstract::Alcohol and substance (drugs and/or alcohol) abuse are major risk factors for traumatic brain injury (TBI); however, it remains unclear whether outcomes differ for those with and without a history of preinjury abuse. A meta-analysis was performed to examine this issue. The PubMed, Embase, and PsycINFO databases were s...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1080/13803395.2016.1248812

    authors: Unsworth DJ,Mathias JL

    更新日期:2017-08-01 00:00:00

  • The relationship between physical activity and symptoms of fatigue, mood, and perceived cognitive impairment in adults with multiple sclerosis.

    abstract::Introduction: Multiple Sclerosis (MS) is achronic neurological condition that requires costly treatment for aconstellation of motor and sensory symptoms, as well as fatigue, depression, and cognitive problems. Given that this pharmacological treatment often results in side effects, there is acrucial need for low-costb...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2019.1614535

    authors: Mayo CD,Miksche K,Attwell-Pope K,Gawryluk JR

    更新日期:2019-09-01 00:00:00

  • Judgment in older adults: development and psychometric evaluation of the Test of Practical Judgment (TOP-J).

    abstract::This article reports on the development and validation of a novel, objective test of judgment for use with older adults. The Test of Practical Judgment (TOP-J) is an open-ended measure that evaluates judgment related to safety, medical, social/ethical, and financial issues. Psychometric features were examined in a sam...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13825580601025908

    authors: Rabin LA,Borgos MJ,Saykin AJ,Wishart HA,Crane PK,Nutter-Upham KE,Flashman LA

    更新日期:2007-10-01 00:00:00

  • Impaired avoidance learning after closed-head injury: dissociation between two tasks due to classical conditioning.

    abstract::Like controls, a Closed-Head Injury (CHI) group learned quickly to press a button during a 3-s warning stimulus in order to avoid a noxious buzzer. In a similar task, however, the CHI group had greater difficulty achieving the learning criterion compared to controls when required to prevent an innocuous visual display...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688639508405150

    authors: Kosmidis MH,Fantie BD

    更新日期:1995-08-01 00:00:00