Specific impairments of selective attention in mild Alzheimer's disease.

Abstract:

:The aim of the present study was to evaluate selective visual attention in subjects affected by Alzheimer's Disease (AD), by means of a computerized spatial exploration test that adopts a Touch Screen (TS) interface, which has already proved able to characterize alternative strategies in performing search tasks. We assessed a group of 16 patients affected by mild to moderate AD, comparing them with 16 control subjects matched for age and education. In the experimental tasks the performance of the AD patients was worse than that of the normal elderly, both quantitatively (slower speeds) and qualitatively (poorer planning and higher number of omissions and perseverations). In the visual attention tasks there appeared to be no close connection between AD patients' performance and increased Reaction Times (RT); this evidenced a specific role of non-elementary cognitive structures enclosed in a higher attentional domain, rather than a general decrease in the speed of basic cognitive processes. Our results are in line with specific AD literature: while psychomotor speed and lower attention levels (sensorimotor) are preferentially impaired in subcortical forms of dementia, the higher levels of selective and divided attention could be the first to deteriorate and appear more markedly disrupted in the Alzheimer type of dementia.

authors

Pignatti R,Rabuffetti M,Imbornone E,Mantovani F,Alberoni M,Farina E,Canal N

doi

10.1080/13803390490520427

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

436-48

issue

4

eissn

1380-3395

issn

1744-411X

journal_volume

27

pub_type

杂志文章
  • Relationship between the apolipoprotein E gene and headache following sports-related concussion.

    abstract:INTRODUCTION:Headache is one of the most commonly reported and longest lasting symptoms that concussed athletes report, yet the etiology of headache symptoms following concussion is not entirely clear. The purpose of this study was to determine whether the e4 allele of the apolipoprotein E (APOE) gene influences the pr...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2016.1177491

    authors: Merritt VC,Ukueberuwa DM,Arnett PA

    更新日期:2016-11-01 00:00:00

  • Individual trajectories of cognitive decline in patients with dementia of the Alzheimer type.

    abstract::The course of decline was studied in 16 patients with probable or definite dementia of the Alzheimer type (DAT) over 2.7 to 6.8 years from first to last evaluation. Overall severity of dementia was measured with the Wechsler Adult Intelligence Scale (WAIS), the Dementia Rating Scale (DRS), and the Mini-Mental State Ex...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688639208402846

    authors: Haxby JV,Raffaele K,Gillette J,Schapiro MB,Rapoport SI

    更新日期:1992-07-01 00:00:00

  • Alzheimer patients show a sensitivity decrement over time on a tonic alertness task.

    abstract::Tonic alertness was investigated in Alzheimer patients and normal elderly subjects. Sensitivity and criterion shifts were investigated across 45 min of continuous testing using a high event rate test with very low target probability. Alzheimer patients showed a significant sensitivity decrement over time that was unre...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1080/01688639408402698

    authors: Brazzelli M,Cocchini G,Della Sala S,Spinnler H

    更新日期:1994-12-01 00:00:00

  • Do subgroups of patients with Alzheimer's disease exhibit asymmetric deficits on memory tests?

    abstract::Several studies have reported asymmetric cognitive profiles in patients with Alzheimer's disease (AD), but these results have almost exclusively been found using non-memory cognitive instruments. The present study investigated whether AD patients who display lateralized profiles on non-memory cognitive instruments als...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1076/jcen.23.2.164.1207

    authors: Demadura T,Delis DC,Jacobson M,Salmon D

    更新日期:2001-04-01 00:00:00

  • Validity of demographically corrected norms for the WAIS-III.

    abstract::The diagnostic validity of new demographically corrected WAIS-III norms was investigated using a sample of 100 patients with traumatic brain injury (TBI) and a matched control group from the standardization sample. Demographically corrected norms were compared to traditional age-corrected norms. Although education acc...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1081/13803390490919155

    authors: Strong CA,Donders J,van Dyke S

    更新日期:2005-08-01 00:00:00

  • Cerebral dominance for speech and handwriting of patients with cortical vascular malformations.

    abstract::Lateralization of speech dominance was established using amobarbital for 22 patients with vascular malformations lateralized to the left cerebral hemisphere. Patients' histories were negative for clinically evident neurological events (e.g., seizures or hemorrhage) prior to adulthood. The vascular lesions were categor...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688639408402690

    authors: Sass KJ,Buchanan CP,Westerveld M,Spencer DD

    更新日期:1994-10-01 00:00:00

  • Cognitive performance in transient global hypoxic brain injury due to moderate drowning.

    abstract:INTRODUCTION:Drowning is a serious and frequently neglected public health threat. Primary respiratory impairment after submersion often leads to brain dysfunction. Depending on the period of global hypoxia (respiratory failure), clinical aspects of neurological dysfunction are evident on the first evaluation after the ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2017.1371674

    authors: Nucci MP,Lukasova K,Vieira G,Sato JR,Amaro Júnior E

    更新日期:2018-06-01 00:00:00

  • The Dot Counting Test adds up: Validation and response pattern analysis in a mixed clinical veteran sample.

    abstract:OBJECTIVE:This study cross-validated the Dot Counting Test (DCT) as a performance validity test (PVT) among a mixed clinical veteran sample. Completion time and error patterns also were examined by validity group and cognitive impairment status. METHOD:This cross-sectional study included 77 veterans who completed the ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2017.1342773

    authors: Soble JR,Santos OA,Bain KM,Kirton JW,Bailey KC,Critchfield EA,O'Rourke JJF,Highsmith JM,González DA

    更新日期:2018-05-01 00:00:00

  • Self-reported everyday memory and depression in patients with multiple sclerosis.

    abstract::Depression and memory difficulties are among the most common complaints voiced by patients with multiple sclerosis (MS). Nevertheless, little is known about how depression might affect patients' perceptions of their memory difficulties. The present investigation was designed to explore this issue. Results supported a ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1076/jcen.26.2.200.28081

    authors: Bruce JM,Arnett PA

    更新日期:2004-04-01 00:00:00

  • Dissociated conditional-associative learning in anorexia nervosa.

    abstract::This study assessed the acquisition of conditional-associations using neutral and individually threatening nouns in 16 females with anorexia nervosa (AN), 16 females with bulimia nervosa (BN) and 16 normal controls (NC). Groups did not differ in terms of age, sex, handedness, depression, intelligence, verbal memory an...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1076/jcen.24.2.176.990

    authors: Murphy R,Nutzinger DO,Paul T,Leplow B

    更新日期:2002-04-01 00:00:00

  • Measuring premorbid IQ in traumatic brain injury: an examination of the validity of the Wechsler Test of Adult Reading (WTAR).

    abstract::Estimation of premorbid IQ in traumatic brain injury (TBI) is clinically and scientifically valuable because it permits the quantification of the cognitive impact of injury. This is achieved by comparing performances on tests of current ability to estimates of premorbid IQ, thereby enabling current capacity to be inte...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803390701300524

    authors: Green RE,Melo B,Christensen B,Ngo LA,Monette G,Bradbury C

    更新日期:2008-02-01 00:00:00

  • Executive function late effects in survivors of pediatric brain tumors and acute lymphoblastic leukemia.

    abstract:BACKGROUND:Survivors of pediatric brain tumors (BT) and acute lymphoblastic leukemia (ALL) are at risk for neurocognitive late effects related to executive function. PROCEDURE:Survivors of BT (48) and ALL (50) completed neurocognitive assessment. Executive function was compared to estimated IQ and population norms by ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2014.943695

    authors: Winter AL,Conklin HM,Tyc VL,Stancel H,Hinds PS,Hudson MM,Kahalley LS

    更新日期:2014-01-01 00:00:00

  • Depressive symptoms and autobiographical memory: A pilot electroencephalography (EEG) study.

    abstract:INTRODUCTION:Functional magnetic resonance imaging studies have shown changes in the activity of medial prefrontal, medial temporal, and occipital regions in major depressive disorder patients during recall of autobiographical memories. Electrophysiological underpinning of these changes is not known. It is also not cle...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2016.1219318

    authors: Knyazev GG,Savostyanov AN,Bocharov AV,Kuznetsova VB

    更新日期:2017-04-01 00:00:00

  • The use of amnestic and nonamnestic composite measures at different thresholds in the neuropsychological diagnosis of MCI.

    abstract::Both amnestic and nonamnestic deficits have been observed in patients with mild cognitive impairment (MCI). Most studies have focused on impairment on single cognitive tests rather than amalgamation of the results of several measures to arrive at a composite impairment index. In this investigation, we examined 20 MCI ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803390600681206

    authors: Loewenstein DA,Acevedo A,Agron J,Martinez G,Duara R

    更新日期:2007-04-01 00:00:00

  • The transience and nature of cognitive impairments in transient global amnesia: a meta-analysis.

    abstract::Transient global amnesia (TGA) is a clinical syndrome characterized by the sudden onset of severe amnesia without concomitant focal neurological symptoms. This meta-analysis of the cognitive characteristics of TGA addressed two main issues. First, we examined the hypothesis that the acute phase of TGA is associated wi...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章,meta分析

    doi:10.1080/13803390801955193

    authors: Jäger T,Bäzner H,Kliegel M,Szabo K,Hennerici MG

    更新日期:2009-01-01 00:00:00

  • Some analyses of forgetting of pictorial material in amnesic and demented patients.

    abstract::Three experiments evaluating the rate of forgetting of pictorial stimuli in amnesic, demented, and normal control subjects are reported. When prolonged exposures of pictorial material were used to equate recognition performance after a 10-min delay, alcoholic Korsakoff (AK) patients and patients with Huntington's Dise...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688638608401309

    authors: Martone M,Butters N,Trauner D

    更新日期:1986-06-01 00:00:00

  • Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging: a comparison of quantitative MRI and neuropsychological findings.

    abstract::Atrophy of specific, regional, and generalized brain structures occurs as a result of the Alzheimer's disease (AD) process. Comparing AD patients with histopathological confirmation of the disease at autopsy to those without autopsy but who were clinically diagnosed using the same antemortem criteria will provide furt...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803390600826579

    authors: Fearing MA,Bigler ED,Norton M,Tschanz JA,Hulette C,Leslie C,Welsh-Bohmer K,Cache County Investigators.

    更新日期:2007-07-01 00:00:00

  • Visuoconstructive performance and regional cerebral glucose metabolism in Alzheimer's disease.

    abstract::The drawings of Alzheimer's disease (AD) patients and elderly control subjects were rated on a number of specific performance scales, such as attention to configuration, attention to detail, and stimulus boundedness. AD patients showed significantly poorer performance than controls on most drawing scales, and the draw...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688639108401088

    authors: Ober BA,Jagust WJ,Koss E,Delis DC,Friedland RP

    更新日期:1991-09-01 00:00:00

  • WAIS and neuropsychological tests: common and unique variance within an epileptic population.

    abstract::Neuropsychological assessment batteries, which traditionally require lengthy administration times, may be composed of multiple tests which measure essentially the same performance attributes. Test redundancies of this nature compromise the adequacy of a test battery from a cost containment perspective. The present stu...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688638508401269

    authors: Kupke T,Lewis R

    更新日期:1985-08-01 00:00:00

  • Cerebral blood flow and neuropsychological functioning in elderly vascular disease patients.

    abstract::This study was designed to determine the relationships between positron emission tomography (PET)-based quantitative measures of cerebral blood flow and cerebrovascular reserve and neuropsychological functioning in elderly individuals with atherosclerotic vascular disease. It was hypothesized that cerebrovascular func...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2011.630653

    authors: Moser DJ,Boles Ponto LL,Miller IN,Schultz SK,Menda Y,Arndt S,Nopoulos PC

    更新日期:2012-01-01 00:00:00

  • Forgetting rate and interference effects on a verbal memory distractor task in patients with temporal lobe epilepsy.

    abstract::To investigate interference effects in lateralized temporal lobe epilepsy (TLE), we compared 79 patients with left (n = 43) or right (n = 36) TLE and 33 healthy controls on a verbal memory distractor task (VMDT) structured according to the Brown-Peterson paradigm. The subjects were also administered a selective remind...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688639608408280

    authors: Giovagnoli AR,Avanzini G

    更新日期:1996-04-01 00:00:00

  • Haptic perception in anorexia nervosa before and after weight gain.

    abstract::Haptic perception of patients with anorexia nervosa (n = 10) was analyzed in a longitudinal study (T0-T1). The haptic explorations consisted of palpating the structure of 12 sunken reliefs in sequence with both hands, eyes closed. After each exploration the structure was reproduced on a piece of paper. In the anorexia...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1076/jcen.23.4.520.1229

    authors: Grunwald M,Ettrich C,Krause W,Assmann B,Dähne A,Weiss T,Gertz HJ

    更新日期:2001-08-01 00:00:00

  • Cognitive and task-related EEG correlates of arithmetic performance in adolescents.

    abstract::Cognitive and neurophysiological correlates of arithmetic calculation, concepts, and applications were examined in 41 adolescents, ages 12-15 years. Psychological and task-related EEG measures which correctly distinguished children who scored low vs. high (using a median split) in each arithmetic subarea were interpre...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688638708410769

    authors: Grunau RV,Low MD

    更新日期:1987-10-01 00:00:00

  • Neuropsychological findings in toxicometabolic confusional states.

    abstract::Patients with acute confusional states display impaired attention and memory with difficulty following complex verbal commands. In addition to these deficits, we have observed a selective impairment in spatial thinking similar to that present following right-hemisphere lesions. Consequently, we compared patients with ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688638808402813

    authors: Lee GP,Hamsher KD

    更新日期:1988-12-01 00:00:00

  • Is the Halstead Category Test a multidimensional instrument?

    abstract::Factor structure of the Halstead Category Test was evaluated in patients with schizophrenia, heterogeneous forms of brain damage, and patient controls using confirmatory factor analysis. Analyses were performed including and excluding subtests 1 and 2. In the first analysis, a three-factor model was optimal, with subt...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1076/jcen.21.2.237.926

    authors: Allen DN,Goldstein G,Mariano E

    更新日期:1999-04-01 00:00:00

  • Effect of trait anxiety on cognitive test performance in adolescents with and without attention-deficit/hyperactivity disorder.

    abstract:INTRODUCTION:Attention-deficit/hyperactivity disorder (ADHD) and anxiety are frequently comorbid disorders associated with different types of abnormal performance on neuropsychological tests. Although some studies have shown that comorbid anxiety alters ADHD test performance, results inconsistently show both improvemen...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2016.1232373

    authors: Ruf BM,Bessette KL,Pearlson GD,Stevens MC

    更新日期:2017-06-01 00:00:00

  • Performance of healthy subjects on an ecologically valid test for social cognition: the short, Dutch Version of The Awareness of Social Inference Test (TASIT).

    abstract::The present paper addresses the psychometric quality of the shortened Dutch version of The Awareness of Social Inference Test (TASIT), a social cognition task comprising dynamic social interactions. Because the original TASIT required a rather long administration time, two shortened parallel forms were developed. Resu...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2014.966661

    authors: Westerhof-Evers HJ,Visser-Keizer AC,McDonald S,Spikman JM

    更新日期:2014-01-01 00:00:00

  • The impact of oculomotor functioning on neuropsychological performance in Huntington disease.

    abstract::Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has b...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/13803395.2015.1101054

    authors: Carvalho JO,Long JD,Westervelt HJ,Smith MM,Bruce JM,Kim JI,Mills JA,Paulsen JS,PREDICT-HD Investigators And Coordinators Of The Huntington Study Group.

    更新日期:2016-01-01 00:00:00

  • Learning and retention of computer-related vocabulary in memory-impaired patients: method of vanishing cues.

    abstract::Several investigators have suggested that microcomputers might serve as useful external aids for memory-impaired patients. However, knowledge of basic computer vocabulary may be necessary for patients to use and benefit from a microcomputer. The present paper describes a procedure, the method of vanishing cues, which ...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688638608401320

    authors: Glisky EL,Schacter DL,Tulving E

    更新日期:1986-06-01 00:00:00

  • Some aspects of memory disorders clearly distinguish dementia of the Alzheimer's type from depressive pseudo-dementia.

    abstract::Two groups of patients affected by mild dementia of the Alzheimer's type (n = 42) or by depressive pseudo-dementia (n = 26) were given a modified version of the Rey's Auditory Verbal Learning Test. The two groups were roughly matched for overall level of cognitive impairment. The main purpose of the research was to de...

    journal_title:Journal of clinical and experimental neuropsychology

    pub_type: 杂志文章

    doi:10.1080/01688639408402617

    authors: Gainotti G,Marra C

    更新日期:1994-02-01 00:00:00