Abstract:
:Dendritic cells (DC) are considered to be important contributors to human immunodeficiency virus type 1 (HIV-1) transmission and pathogenesis. As the first target cells in mucosal tissues, they can be become productively infected and can also capture virions and transfer them efficiently to CD4(+) T cells located within lymphoid tissues. Resting CD4(+) T cells appear to be another major target of HIV-1 in vivo, yet several blocks restrict replication in such cells. We report here that physical contact between virus-infected quiescent CD4(+) T cells and uninfected autologous immature DC in the absence of any foreign antigen relieves these restrictions, allowing a highly productive HIV-1 replication.
journal_name
J Viroljournal_title
Journal of virologyauthors
Barat C,Gilbert C,Tremblay MJdoi
10.1128/JVI.01420-08subject
Has Abstractpub_date
2009-03-01 00:00:00pages
2778-82issue
6eissn
0022-538Xissn
1098-5514pii
JVI.01420-08journal_volume
83pub_type
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