Significance of background optical properties, time-resolved information and optode arrangement in diffuse optical imaging of term neonates.

Abstract:

:The significance of accurate knowledge of background optical properties and time-resolved information in reconstructing images of hemodynamic changes in the neonatal brain from diffuse optical imaging data was studied using Monte Carlo (MC) simulation. A segmented anatomical magnetic resonance (MR) image and literature-derived optical properties for each tissue type were used to create a voxel-based anatomical model. Small absorbing perturbations were introduced into the anatomical model to simulate localized hemodynamic responses related to brain activation. Perturbation MC (pMC) was used as the primary method of image reconstruction. For comparison, reconstructions were also performed using the finite element method (FEM) to solve the diffusion approximation (DA) to the radiative transfer equation (RTE). The effect of optode layout was investigated using three different grids. Of the factors studied, the density of the optode grid was found to have the greatest effect on image quality. The use of time-resolved information significantly improved the spatial accuracy with all optode grids. Adequate knowledge and modeling of the optical properties of the background was found to significantly improve the spatial accuracy of the reconstructed images and make the recovery of contrast of absorption changes more consistent over simplified modeling. Localization accuracy of small perturbations was found to be 2-3 mm with accurate a priori knowledge of the background optical properties, when a grid with high optode density (>1 optode cm(-2)) was used.

journal_name

Phys Med Biol

authors

Heiskala J,Hiltunen P,Nissilä I

doi

10.1088/0031-9155/54/3/005

subject

Has Abstract

pub_date

2009-02-07 00:00:00

pages

535-54

issue

3

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(09)85545-0

journal_volume

54

pub_type

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