Abstract：
:Therapy with helium ions is currently receiving significantly increasing interest because helium ions have a sharper penumbra than protons and undergo less fragmentation than carbon ions and thus require less complicated dose calculations. For any ion of interest in hadron therapy, the accuracy of dose delivery is limited by range uncertainties. This has led to efforts by several groups to develop in vivo verification techniques, including positron emission tomography (PET), for monitoring of the dose delivery. Beam-on PET monitoring during proton therapy through the detection of short-lived positron emitters such as 12N (T 1/2 = 11 ms), an emerging PET technique, provides an attractive option given the achievable range accuracy, minimal susceptibility to biological washout and provision of near prompt feedback. Extension of this approach to helium ions requires information on the production yield of relevant short-lived positron emitters. This study presents the first measurements of the production of short-lived positron emitters in water, graphite, calcium and phosphorus targets irradiated with 59 MeV/u 3He and 50 MeV/u 4He beams. For these targets, the most produced short-lived nuclides are 13O/12N (T 1/2 = 8.6/11 ms) on water, 13O/12N on graphite, 43Ti/41Sc/42Sc (T 1/2 = 509-680 ms) on calcium, 28P (T 1/2 = 268 ms) on phosphorus. A translation of the results from elemental targets to PMMA and representative tissues such as adipose tissue, muscle, compact and cortical bone, shows the dominance of 13O/12N in at least the first 20 s of an irradiation with 4He and somewhat longer with 3He. As the production of 13O/12N in a 3He irradiation is 3-4 times higher than in a 4He irradiation, from a statistical point of view, range verification using 13O/12N PET imaging will be about 2 times more precise for a 3He irradiation compared to a 4He irradiation.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Ozoemelam I,van der Graaf E,Brandenburg S,Dendooven Pdoi
10.1088/1361-6560/ab51c3subject
Has Abstractpub_date
2019-12-05 00:00:00pages
235012issue
23eissn
0031-9155issn
1361-6560journal_volume
64pub_type
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