Comments on 'The influence of dose heterogeneity on tumor control probability in fractionated radiation therapy'.

Abstract:

:By analyzing the radiobiological model, and the equations derived from the model, it is shown that the main results of the article 'The influence of dose heterogeneity on tumor control probability in fractionated radiation therapy' by Wiklund et al (2011 Phys. Med. Biol. 56 7585-600) are valid only under the condition that the dose to any cell is statistically independent of the dose to any other cell in the same fraction. This condition is in practice not fulfilled for radiotherapy. Hence the main results and most of the discussion are not applicable to fractionated radiation therapy.

journal_name

Phys Med Biol

authors

Grusell E

doi

10.1088/0031-9155/58/18/6585

subject

Has Abstract

pub_date

2013-09-21 00:00:00

pages

6585-9

issue

18

eissn

0031-9155

issn

1361-6560

journal_volume

58

pub_type

评论,信件
  • A Monte Carlo investigation of contaminant electrons due to a novel in vivo transmission detector.

    abstract::A novel transmission detector (IBA Dosimetry, Germany) developed as an IMRT quality assurance tool, intended for in vivo patient dose measurements, is studied here. The goal of this investigation is to use Monte Carlo techniques to characterize treatment beam parameters in the presence of the detector and to compare t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/4/020

    authors: Asuni G,Jensen JM,McCurdy BM

    更新日期:2011-02-21 00:00:00

  • Report of the IPSM working party on low- and medium-energy x-ray dosimetry. Institute of Physical Sciences in Medicine.

    abstract::New values of the factors required to convert the reading of a radiation dosemeter calibrated in terms of air kerma (or exposure) into absorbed dose to water for medium-energy x-radiation were given in a code of practice published by the IAEA in 1987. These are not considered to possess sufficient support from other s...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/36/8/001

    authors:

    更新日期:1991-08-01 00:00:00

  • A Monte Carlo investigation of dual-energy-window scatter correction for volume-of-interest quantification in 99Tcm SPECT.

    abstract::Using Monte Carlo simulation of 99Tcm single-photon-emission computed tomography (SPECT), we investigate the effects of tissue-background activity, tumour location, patient size, uncertainty of energy windows, and definition of tumour region on the accuracy of quantification. The dual-energy-window method of correctio...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/40/1/015

    authors: Luo JQ,Koral KF,Ljungberg M,Floyd CE Jr,Jaszczak RJ

    更新日期:1995-01-01 00:00:00

  • Numerical model of heat transfer in the human eye with consideration of fluid dynamics of the aqueous humour.

    abstract::In this work we present a new 3D numerical model for heat transfer in the human eye, which takes into account the aqueous humour flow in the anterior chamber. We show that consideration of this phenomenon in the calculations alters the temperature distribution on the corneal and lens surfaces, without, however, notice...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/19/003

    authors: Karampatzakis A,Samaras T

    更新日期:2010-10-07 00:00:00

  • Quantitative evaluation of myocardial function by a volume-normalized map generated from relative blood flow.

    abstract::Our study aimed to quantitatively evaluate blood flow in the left ventricle (LV) of apical hypertrophic cardiomyopathy (APH) by combining wall thickness obtained from cardiac magnetic resonance imaging (MRI) and myocardial perfusion from single-photon emission computed tomography (SPECT). In this study, we considered ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/14/019

    authors: Fukami T,Sato H,Wu J,Lwin TT,Yuasa T,Kawano S,Iida K,Akatsuka T,Hontani H,Takeda T,Tamura M,Yokota H

    更新日期:2007-07-21 00:00:00

  • Physical characterization and performance comparison of active- and passive-pixel CMOS detectors for mammography.

    abstract::We investigated the physical characteristics of two complementary metal oxide semiconductor (CMOS) mammography detectors. The detectors featured 14-bit image acquisition, 50 microm detector element (del) size and an active area of 5 cm x 5 cm. One detector was a passive-pixel sensor (PPS) with signal amplification per...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/6/022

    authors: Elbakri IA,McIntosh BJ,Rickey DW

    更新日期:2009-03-21 00:00:00

  • Inclusion of organ movements in IMRT treatment planning via inverse planning based on probability distributions.

    abstract::In this paper, we investigate an off-line strategy to incorporate inter-fraction organ motion in IMRT treatment planning. It was suggested that inverse planning could be based on a probability distribution of patient geometries instead of a single snap shot. However, this concept is connected to two intrinsic problems...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/17/013

    authors: Unkelbach J,Oelfke U

    更新日期:2004-09-07 00:00:00

  • Contactless remote induction of shear waves in soft tissues using a transcranial magnetic stimulation device.

    abstract::This study presents the first observation of shear waves induced remotely within soft tissues. It was performed through the combination of a transcranial magnetic stimulation device and a permanent magnet. A physical model based on Maxwell and Navier equations was developed. Experiments were performed on a cryogel pha...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/6/2582

    authors: Grasland-Mongrain P,Miller-Jolicoeur E,Tang A,Catheline S,Cloutier G

    更新日期:2016-03-21 00:00:00

  • Diffusion coefficient for photon transport in turbid media.

    abstract::Light propagation in a turbid medium is considered using the linear transport equation. The existence of a diffusion length is proved for the Henyey-Greenstein scattering kernel for all absorption ratios. Numerical methods are given that allow accurate computation of the diffusion coefficient quite easily. ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/48/23/012

    authors: Sahni DC,Dahl EB,Sjöstrand NG

    更新日期:2003-12-07 00:00:00

  • Simulation study of the second-generation MR-compatible SPECT system based on the inverted compound-eye gamma camera design.

    abstract::In this paper, we present simulation studies for the second-generation MRI compatible SPECT system, MRC-SPECT-II, based on an inverted compound eye (ICE) gamma camera concept. The MRC-SPECT-II system consists of a total of 1536 independent micro-pinhole-camera-elements (MCEs) distributed in a ring with an inner diamet...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aaa4fb

    authors: Lai X,Meng LJ

    更新日期:2018-02-12 00:00:00

  • Simulations of a micro-PET system based on liquid xenon.

    abstract::The imaging performance of a high-resolution preclinical micro-positron emission tomography (micro-PET) system employing liquid xenon (LXe) as the gamma-ray detection medium was simulated. The arrangement comprises a ring of detectors consisting of trapezoidal LXe time projection ionization chambers and two arrays of ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/6/1685

    authors: Miceli A,Glister J,Andreyev A,Bryman D,Kurchaninov L,Lu P,Muennich A,Retiere F,Sossi V

    更新日期:2012-03-21 00:00:00

  • Evaluation of the reproducibility of lung motion probability distribution function (PDF) using dynamic MRI.

    abstract::Treatment planning based on probability distribution function (PDF) of patient geometries has been shown a potential off-line strategy to incorporate organ motion, but the application of such approach highly depends upon the reproducibility of the PDF. In this paper, we investigated the dependences of the PDF reproduc...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/2/004

    authors: Cai J,Read PW,Altes TA,Molloy JA,Brookeman JR,Sheng K

    更新日期:2007-01-21 00:00:00

  • Robust principal component analysis-based four-dimensional computed tomography.

    abstract::The purpose of this paper for four-dimensional (4D) computed tomography (CT) is threefold. (1) A new spatiotemporal model is presented from the matrix perspective with the row dimension in space and the column dimension in time, namely the robust PCA (principal component analysis)-based 4D CT model. That is, instead o...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/11/002

    authors: Gao H,Cai JF,Shen Z,Zhao H

    更新日期:2011-06-07 00:00:00

  • Measurement of charged particle yields from PMMA irradiated by a 220 MeV/u (12)C beam.

    abstract::The radiation used in hadrontherapy treatments interacts with the patient body producing secondary particles, either neutral or charged, that can be used for dose and Bragg peak monitoring and to provide a fast feedback on the treatment plans. Recent results obtained from the authors on simplified setups (mono-energet...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/7/1857

    authors: Piersanti L,Bellini F,Bini F,Collamati F,De Lucia E,Durante M,Faccini R,Ferroni F,Fiore S,Iarocci E,La Tessa C,Marafini M,Mattei I,Patera V,Ortega PG,Sarti A,Schuy C,Sciubba A,Vanstalle M,Voena C

    更新日期:2014-04-07 00:00:00

  • Estimation of tissue resistivities from multiple-electrode impedance measurements.

    abstract::In order to measure in vivo resistivity of tissues in the thorax, the possibility of combining anatomical data extracted from high-resolution images with multiple-electrode impedance measurements, a priori knowledge of the range of tissue resistivities, and a priori data on the instrumentation noise is assessed in thi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/39/1/001

    authors: Eyüboğlu BM,Pilkington TC,Wolf PD

    更新日期:1994-01-01 00:00:00

  • 1D dynamic beam modulation: methods to counteract inertia effects.

    abstract::Dynamic modulation can be affected by inaccuracies when the required acceleration is larger than the highest allowed by the mechanical characteristics of the whole apparatus. In this study, inertia effects have been investigated with regard to the single absorber 1D modulation, analysing primarily how the acceleration...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/44/11/401

    authors: Corletto D,Broggi S,Fiorino C,Mangili P,Calandrino R,Lev A,Gennari D,Rudello F

    更新日期:1999-11-01 00:00:00

  • Evaluation of the induced electric field and compliance procedure for a wireless power transfer system in an electrical vehicle.

    abstract::In this study, an induced electric field in a human body is evaluated for the magnetic field leaked from a wireless power transfer system for charging an electrical vehicle. The magnetic field from the wireless power transfer system is modelled computationally, and its effectiveness is confirmed by comparison with the...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/21/7583

    authors: Laakso I,Hirata A

    更新日期:2013-11-07 00:00:00

  • Implementation of tetrahedral-mesh geometry in Monte Carlo radiation transport code PHITS.

    abstract::A new function to treat tetrahedral-mesh geometry was implemented in the particle and heavy ion transport code systems. To accelerate the computational speed in the transport process, an original algorithm was introduced to initially prepare decomposition maps for the container box of the tetrahedral-mesh geometry. Th...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa6b45

    authors: Furuta T,Sato T,Han MC,Yeom YS,Kim CH,Brown JL,Bolch WE

    更新日期:2017-06-21 00:00:00

  • The replacement correction factors for cylindrical chambers in high-energy photon beams.

    abstract::The values of the replacement correction factors (P(repl), or in the IAEA's notation p(dis)p(cav)) used for cylindrical chambers in high-energy photon beams represent one of the most significant differences between the AAPM and the IAEA dosimetry protocols. In a previous study (Wang L L W and Rogers D W O 2008 Med. Ph...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/6/014

    authors: Wang LL,Rogers DW

    更新日期:2009-03-21 00:00:00

  • Liver-ultrasound based motion modelling to estimate 4D dose distributions for lung tumours in scanned proton therapy.

    abstract::Motion mitigation strategies are crucial for scanned particle therapy of mobile tumours in order to prevent geometrical target miss and interplay effects. We developed a patient-specific respiratory motion model based on simultaneously acquired time-resolved volumetric MRI and 2D abdominal ultrasound images. We presen...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abaa26

    authors: Giger AT,Krieger M,Jud C,Duetschler A,Salomir R,Bieri O,Bauman G,Nguyen D,Weber DC,Lomax AJ,Zhang Y,Cattin PC

    更新日期:2020-07-28 00:00:00

  • Effective energy resolution and scatter rejection in nuclear medicine.

    abstract::All available imaging devices in nuclear medicine have finite energy resolution. This leads to inclusion of scattered radiation, which in turn degrades the image quality. Different scatter correction schemes therefore try to eliminate the effect of scattered radiation. On the other hand, improvement of the camera's in...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/34/1/008

    authors: Wirth V

    更新日期:1989-01-01 00:00:00

  • Accelerated time-of-flight (TOF) PET image reconstruction using TOF bin subsetization and TOF weighting matrix pre-computation.

    abstract::Time-of-flight (TOF) positron emission tomography (PET) technology has recently regained popularity in clinical PET studies for improving image quality and lesion detectability. Using TOF information, the spatial location of annihilation events is confined to a number of image voxels along each line of response, there...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/3/1309

    authors: Mehranian A,Kotasidis F,Zaidi H

    更新日期:2016-02-07 00:00:00

  • Dielectric properties of supercooled cryoprotectant agents.

    abstract::The dielectric properties of glycerol, propylene glycol, ethylene glycol and dimethyl sulphoxide have been measured in various aqueous concentrations generally sufficient to allow supercooling rather than freezing. The temperature range investigated is from -80 degrees C to +20 degrees C and the frequency range is 100...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/10/014

    authors: Michelson SC,Evans S

    更新日期:1996-10-01 00:00:00

  • The influence of penetrating radiation on collimator performance.

    abstract::Geometric and penetration responses of a multihole focusing collimator to a point source have been determined using a digital computer and a ray tracing technique. Results are presented as point and line spread functions for collimated rays and penetrating rays, and as plane sensitivities and modulation transfer funct...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/26/1/011

    authors: Jahns MJ

    更新日期:1981-01-01 00:00:00

  • Development of the complex permittivity measurement system for high-loss biological samples using the free space method in quasi-millimeter and millimeter wave bands.

    abstract::The free space method using a pair of lens antennas was modified for the complex permittivity measurement of biological samples from 20 to 110 GHz. Two methodologies were used to obtain the complex permittivities by the free space method, which were based on the reflection and transmission coefficients. The measuremen...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/5/1625

    authors: Sasaki K,Segawa H,Mizuno M,Wake K,Watanabe S,Hashimoto O

    更新日期:2013-03-07 00:00:00

  • Investigation of the performance of antiscatter grids: Monte Carlo simulation studies.

    abstract::Monte Carlo methods have been applied to the study of the performance of antiscatter grids in radiography. Photon histories for imaging with a 20 cm thick water phantom irradiated with an 80 kV x-ray spectrum were generated by Monte Carlo simulation. The scattering and absorption of the photons transmitted from the ph...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/27/6/002

    authors: Chan HP,Doi K

    更新日期:1982-06-01 00:00:00

  • Deformable and durable phantoms with controlled density of scatterers.

    abstract::We have developed deformable and durable optical tissue phantoms with a simple and well-defined microstructure including a novel combination of scatterers and a matrix material. These were developed for speckle and elastography investigations in optical coherence tomography, but should prove useful in many other field...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/13/N01

    authors: Bisaillon CE,Lamouche G,Maciejko R,Dufour M,Monchalin JP

    更新日期:2008-07-07 00:00:00

  • A new approach to account for the medium-dependent effect in model-based dose calculations for kilovoltage x-rays.

    abstract::This study presents a new approach to accurately account for the medium-dependent effect in model-based dose calculations for kilovoltage (kV) x-rays. This approach is based on the hypothesis that the correction factors needed to convert dose from model-based dose calculations to absorbed dose-to-medium depend on both...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/13/011

    authors: Pawlowski JM,Ding GX

    更新日期:2011-07-07 00:00:00

  • Evidence for a significant timer error on a linear accelerator: consequences for a special therapy application.

    abstract::A significant timer error has been found on a linear accelerator used for intraoperative radiation therapy. Since typical treatment doses range up to 20 Gy, calibrations that do not account for this effect can incur a large dosimetry error. The effect is dose rate dependent, but energy independent. For a dose rate of ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/43/10/031

    authors: Biggs PJ

    更新日期:1998-10-01 00:00:00

  • Effects of body habitus on internal radiation dose calculations using the 5-year-old anthropomorphic male models.

    abstract::Computational phantoms are commonly used in internal radiation dosimetry to assess the amount and distribution pattern of energy deposited in various parts of the human body from different internal radiation sources. Radiation dose assessments are commonly performed on predetermined reference computational phantoms wh...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa75b4

    authors: Xie T,Kuster N,Zaidi H

    更新日期:2017-07-13 00:00:00