Abstract:
:The Hug-Kellerer (H-K) equation is one of the earliest proposed radiation cell survival curves. We examine this equation in view of the recent perceived need for a universal cell survival curve which would be applicable to single radiation fractions at high doses. We derive relationships between the three parameters of the H-K equation and the parameters alpha and beta of the linear-quadratic equation. Using these relationships we show how the H-K equation can be used to determine single-fraction doses which are equivalent in theory to the dose in a conventional multi-fraction course of radiation therapy.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Ekstrand KEdoi
10.1088/0031-9155/55/10/N01subject
Has Abstractpub_date
2010-05-21 00:00:00pages
N267-73issue
10eissn
0031-9155issn
1361-6560pii
S0031-9155(10)39886-0journal_volume
55pub_type
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