The Hug-Kellerer equation as the universal cell survival curve.

Abstract:

:The Hug-Kellerer (H-K) equation is one of the earliest proposed radiation cell survival curves. We examine this equation in view of the recent perceived need for a universal cell survival curve which would be applicable to single radiation fractions at high doses. We derive relationships between the three parameters of the H-K equation and the parameters alpha and beta of the linear-quadratic equation. Using these relationships we show how the H-K equation can be used to determine single-fraction doses which are equivalent in theory to the dose in a conventional multi-fraction course of radiation therapy.

journal_name

Phys Med Biol

authors

Ekstrand KE

doi

10.1088/0031-9155/55/10/N01

subject

Has Abstract

pub_date

2010-05-21 00:00:00

pages

N267-73

issue

10

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(10)39886-0

journal_volume

55

pub_type

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