Abstract:
OBJECTIVE:To investigate the relationship between age-associated MRI leukoaraiosis or white matter hyperintensities (WMH) and cortical acetylcholinesterase (AChE) activity. BACKGROUND:One possible mechanism of cognitive decline in elderly individuals with leukoaraiosis is disruption of cholinergic fibers by strategically located white matter lesions. Periventricular lesions may have a higher chance of disrupting cholinergic projections compared with more superficial nonperiventricular white matter lesions because of anatomic proximity to the major cholinergic axonal projection bundles that originate from the basal forebrain. METHODS:Community-dwelling, middle-aged and elderly subjects without dementia (mean age 71.0 +/- 9.2 years; 55-84 years; n = 18) underwent brain MRI and AChE PET imaging. The severity of periventricular and nonperiventricular WMH on fluid-attenuated inversion recovery MRI images was scored using the semiquantitative rating scale of Scheltens et al. [11C]methyl-4-piperidinyl propionate AChE PET imaging was used to assess cortical AChE activity. Age-corrected Spearman partial rank correlation coefficients were calculated. RESULTS:The severity of periventricular (R = -0.52, p = 0.04) but not nonperiventricular (R = -0.20, not significant) WMH was inversely related to global cortical AChE activity. Regional cortical cholinergic effects of periventricular WMH were most significant for the occipital lobe (R = -0.58, p = 0.02). CONCLUSIONS:The presence of periventricular but not nonperiventricular white matter hyperintensities (WMH) is significantly associated with lower cortical cholinergic activity. These findings support a regionally specific disruption of cholinergic projection fibers by WMH.
journal_name
Neurologyjournal_title
Neurologyauthors
Bohnen NI,Müller ML,Kuwabara H,Constantine GM,Studenski SAdoi
10.1212/WNL.0b013e3181a187c6subject
Has Abstractpub_date
2009-04-21 00:00:00pages
1411-6issue
16eissn
0028-3878issn
1526-632Xpii
72/16/1411journal_volume
72pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Neurologic abnormalities were seen in 13 of 20 patients with a history of chronic solvent vapor (primarily toluene) abuse for 2 or more years. The patients were evaluated after an abstinence period of at least 4 weeks, to avoid neurologic effects of acute intoxication. Neurologic signs included cognitive (60%), pyrami...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.5.698
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to clarify the characteristic brain MRI findings for genetically diagnosed CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy). METHODS:Seven patients with CARASIL carrying HTRA1 mutations (representing 6 Japanese families) we...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001803
更新日期:2015-08-04 00:00:00
abstract::We followed 18 multiple sclerosis patients clinically and with repeated brain MRIs with and without gadolinium for over 1 year. Clinical evaluations included scoring on the Kurtzke Expanded Disability Status Scale (EDSS) and the Ambulation Index (AI) scale. There was a significant correlation between the change in EDS...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.11.2120
更新日期:1994-11-01 00:00:00
abstract::The presence of the APOE epsilon 4 allele encoding apolipoprotein E4 (apoE4) is the major genetic risk factor for late-onset Alzheimer's disease (AD). However, the molecular and cellular mechanisms by which APOE epsilon 4 renders AD risk are unclear. In this report, we present genetic evidence that an apoE receptor, L...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.1.56
更新日期:1997-07-01 00:00:00
abstract::The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.7.972
更新日期:2001-04-10 00:00:00
abstract::About 9% of patients presenting to a Huntington disease (HD) clinic for evaluation of possible HD lacked a family history of the disorder. HD was the final diagnosis in 53 to 83% of these patients. As a group, HD-affected individuals without a family history of HD were older and had fewer CAG repeats than the average ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.6.1578
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:We sought to assess the prevalence, correlates, and consequences of periodic limb movements of sleep (PLMS) in persons with obstructive sleep apnea (OSA) and the effect (worsening or improvement) of continuous positive airway pressure (CPAP) therapy on PLMS in a large prospective multicenter randomized contro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008844
更新日期:2020-04-28 00:00:00
abstract::The authors describe diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) changes in the hippocampus within 48 hours of acute symptomatic seizures or status epilepticus in 12 patients. DWI showed increased signal and a decreased apparent diffusion coefficient (ADC) in all patients, with correspon...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000218207.18707.f4
更新日期:2006-06-13 00:00:00
abstract:OBJECTIVE:To elucidate the phenotype, genotype, and MRI findings of Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and mutation carriers. METHODS:The authors studied 40 members of nine unrelated Korean CADASIL families. After genetic analysis o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000216259.99811.50
更新日期:2006-05-23 00:00:00
abstract:OBJECTIVE:We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS). METHODS:Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31829c5ed5
更新日期:2013-07-23 00:00:00
abstract::The authors demonstrate the potential for poststroke return of activation in regions normally involved in touch discrimination in a serial, whole-brain fMRI study of a patient with marked sensory loss followed by good recovery. A return of activation in ipsilesional primary and bilateral secondary somatosensory cortic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.5.749
更新日期:2002-09-10 00:00:00
abstract:OBJECTIVE:To report 2 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who presented acutely with Miller Fisher syndrome and polyneuritis cranialis, respectively. METHODS:Patient data were obtained from medical records from the University Hospital "Príncipe de Asturias," Alcalá de He...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009619
更新日期:2020-08-04 00:00:00
abstract:OBJECTIVE:There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. METHODS:We assessed a cohort of participants at r...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002944
更新日期:2016-08-09 00:00:00
abstract::We have performed positron emission tomography (PET) with 2-deoxy-2[18F]fluoro-D-glucose (FDG) in eight infants and children (aged 18 days to 5 years) with medically refractory epilepsy of neonatal onset. It was hypothesized that in at least some of these infants a surgical approach (focal resection, cerebral hemisphe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.8.1178
更新日期:1988-08-01 00:00:00
abstract::When the WHO's Topic Advisory Group for Neurology (TAG) started work on revision of the ICD-10 diagnostic codes in June 2009, the issues were daunting. The existing classification was produced a generation ago and the need to move to the digital age was becoming imperative. Appreciating modern advances in genetics and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31829a333c
更新日期:2013-07-09 00:00:00
abstract:OBJECTIVE:To evaluate the integrity of the dorsal striatal dopaminergic innervation in rigid and choreic Huntington disease (HD). BACKGROUND:Some patients with HD have an akinetic-rigid phenotype. It has been suggested that nigrostriatal in addition to striatal pathology is present in this subgroup. The authors sought...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.9.1753
更新日期:2000-05-09 00:00:00
abstract:OBJECTIVE:The pedunculopontine nucleus region (PPNR) is being investigated as a target for deep brain stimulation (DBS) in Parkinson disease (PD), particularly for gait and postural impairment. A greater understanding of how PPNR activities and oscillations are modulated with voluntary movements is crucial to the devel...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181f25b35
更新日期:2010-09-14 00:00:00
abstract:OBJECTIVE:To evaluate teriflunomide as add-on therapy to ongoing stable-dosed interferon-β (IFNβ) in patients with relapsing forms of multiple sclerosis (RMS). METHODS:A total of 118 patients with RMS were randomly assigned 1:1:1 to receive oral placebo or teriflunomide, 7 or 14 mg, once daily for 24 weeks; 86 patient...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0b013e318258f7d4
更新日期:2012-06-05 00:00:00
abstract:OBJECTIVE:To investigate recovery of medical decision-making capacity (MDC) over the first year following traumatic brain injury (TBI). METHODS:A total of 177 participants (111 persons with TBI and 66 healthy controls) were recruited from an inpatient/outpatient TBI rehabilitation unit and outpatient neurology departm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003079
更新日期:2016-09-06 00:00:00
abstract:OBJECTIVE:Activation of the type 1 interferon (IFN1) pathway is a prominent feature of dermatomyositis (DM) muscle and may play a role in the pathogenesis of this disease. However, the relevance of the IFN1 pathway in patients with other types of myositis such as the antisynthetase syndrome (AS), immune-mediated necrot...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008128
更新日期:2019-09-17 00:00:00
abstract::Using an in vitro blood-nerve barrier (BNB) model, the authors tested the effect of various monoclonal antiganglioside antibodies on BNB function. Only anti-GM1 antibody significantly facilitated BNB leakage in a concentration-dependent, complement-independent manner. This study provided evidence that anti-GM1 antibod...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.4.585
更新日期:2000-08-22 00:00:00
abstract::Seizures in a transplant candidate or recipient raise complicated management issues, but there are no results from controlled drug trials to guide their pharmacologic treatment. Most seizures in the transplant population are isolated events that do not require long-term antiseizure therapy. Short-term therapy, however...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.67.12_suppl_4.s34
更新日期:2006-12-26 00:00:00
abstract::We performed a quantitative immunocytochemical study using a polyclonal antibody directed against choline acetyltransferase (ChAT) in the lower pontine reticular formation in four control subjects and three patients with progressive supranuclear palsy (PSP). In the normal brains, there was detectable ChAT-like immunor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.10.1593
更新日期:1991-10-01 00:00:00
abstract:OBJECTIVE:To investigate whether sex and race differences exist in dementia diagnosis risk associated with traumatic brain injury (TBI) among older veterans. METHODS:Using Fine-Gray regression models, we investigated incident dementia diagnosis risk with TBI exposure by sex and race. RESULTS:After the exclusion of ba...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010617
更新日期:2020-09-29 00:00:00
abstract:OBJECTIVE:In this study, we aimed to investigate the effect of hypoglycemia on cardiovascular outcomes in a sample of patients with chronic kidney disease (CKD). METHODS:Information about study participants was extracted from the National Health Insurance Research Database of Taiwan for the years 1998 through 2008. We...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000711
更新日期:2014-08-19 00:00:00
abstract::A 33-year-old man with complex partial seizures developed de novo hypertension after the initiation of carbamazepine, which resolved on discontinuation. Although rare, a variety of cardiovascular effects including hypertension have been reported with carbamazepine. Numerous mechanisms may be responsible; however, shar...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.2.275
更新日期:2002-07-23 00:00:00
abstract:OBJECTIVE:To investigate the cognitive decline in dementia with Lewy bodies (DLBs) and characterize the contribution of Lewy bodies (LBs) to cognitive impairment in the presence of concurrent Alzheimer disease (AD). METHODS:Cognitive deficits and rates of progression attributable to DLB and AD neuropathology were inve...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000180964.60708.c2
更新日期:2005-10-25 00:00:00
abstract::In seven of eight patients with progressive multiple sclerosis subjected to long-term plasmapheresis in combination with azathioprine and pulsed prednisone therapy, we found modest improvement of neurologic function. There was no change in auditory and visual evoked responses or serum demyelinating activity. In six of...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.10.1023
更新日期:1980-10-01 00:00:00
abstract:OBJECTIVE:To test the hypotheses predicted in a hypothetical model of Alzheimer disease (AD) biomarkers that rates of β-amyloid (Aβ) accumulation on PET imaging are not related to hippocampal neurodegeneration whereas rates of neurodegenerative brain atrophy depend on the presence of both amyloid and neurodegeneration ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000386
更新日期:2014-05-06 00:00:00
abstract:OBJECTIVE:To identify neural sites associated with gaze-evoked tinnitus (GET), an unusual condition that may follow cerebellar-pontine angle surgery. METHODS:The authors examined eight patients with GET and used PET to map the neural sites activated by lateral gaze in them and seven age- and sex-matched control subjec...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.4.472
更新日期:2001-02-27 00:00:00