Relaxin-induced changes in renal function and RXFP1 receptor expression in the female rat.

Abstract:

:Relaxin causes renal hyperfiltration, natriuresis, and diuresis in male rats. This study determined the effect of recombinant human relaxin (rhRLX) on renal function in the female rat. After 7 days of rhRLX treatment (0.4 microg/h) urinary excretion of sodium and chloride were significantly lower in the rhRLX-treated group, but urine flow rate was not different from that in controls. Quantitative PCR showed that the RXFP1 receptor was expressed in both the renal cortex and medulla; immuno-localization revealed expression in the proximal tubule and inner medullary collecting ducts. These data show that relaxin elicits pregnancy-like changes in renal function in the female rat.

journal_name

Ann N Y Acad Sci

authors

Bogzil AH,Ashton N

doi

10.1111/j.1749-6632.2008.03797.x

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

313-6

eissn

0077-8923

issn

1749-6632

pii

NYAS03797

journal_volume

1160

pub_type

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