Clinical trials of pharmacotherapy for spinal cord injury.

Abstract:

:Spinal cord injury remains with limited natural recovery and only a few general ineffective treatment options. Recent publications have reported enhanced neurologic recovery with the use of methylprednisolone and GM-1 ganglioside. The results of the Maryland GM-1 Ganglioside Study reported a significant drug effect with respect to the fraction of patients that had a change of two or more Frankel grades from entrance into the study to 1-year follow-up. This study formed the basis for the currently ongoing larger placebo-controlled multicentered study using Sygen GM-1 following acute spinal cord injury. This study has entered 797 patients and is expected to present results in early 1998.

journal_name

Ann N Y Acad Sci

authors

Geisler FH

doi

10.1111/j.1749-6632.1998.tb09689.x

subject

Has Abstract

pub_date

1998-06-19 00:00:00

pages

374-81

eissn

0077-8923

issn

1749-6632

journal_volume

845

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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