Magnetorelaxometric quantification of magnetic nanoparticles in an artery model after ex vivo magnetic drug targeting.

Abstract:

:In magnetic drug targeting a chemotherapeutic agent is bound to coated magnetic nanoparticles, which are administered to the blood vessel system and subsequently focused by an external applied magnetic field. The optimization of intra-arterial magnetic drug targeting (MDT) requires detailed knowledge about the biodistribution of particles in the artery and the respective surrounding after the application. Here, we demonstrate the potential of magnetorelaxometry for quantifying the distribution of magnetic nanoparticles in the artery. To this end, we present a magnetorelaxometry investigation of a MDT study in an artery model. In particular, the absolute magnetic nanoparticle accumulation along the artery as well as the uptake profile along the region around the MDT-magnet position was quantified.

journal_name

Phys Med Biol

authors

Richter H,Wiekhorst F,Schwarz K,Lyer S,Tietze R,Alexiou Ch,Trahms L

doi

10.1088/0031-9155/54/18/N03

subject

Has Abstract

pub_date

2009-09-21 00:00:00

pages

N417-24

issue

18

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(09)12144-9

journal_volume

54

pub_type

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