Abstract:
:Many immune parameters exhibit daily and circadian oscillations, including the number of circulating cells and levels of cytokines in the blood. Mice also have a differential susceptibility to lipopolysaccharide (LPS or endotoxin)-induced endotoxic shock, depending on the administration time in the 24 h light-dark (LD) cycle. We replicated these results in LD, but we did not find temporal differences in LPS-induced mortality in constant darkness (DD). Animals challenged with LPS showed only transient effects on their wheel locomotor activity rhythm without modification of circadian period and phase. Levels of several key factors involved in the pathology of sepsis and septic shock were tested in LD. We found that LPS-induced levels of interleukin (IL)-1beta, IL-6, JE (MCP-1), and MIP1alpha were significantly higher at zeitgeber time (ZT) 11 (time of increased mortality) than at ZT19 (ZT12 = time of lights-off in the animal quarters for the 12L:12D condition). Our results indicate that the differences found in mortality that are dependent on the time of LPS-challenge are not directly related to an endogenous circadian clock, and that some relevant immune factors in the development of sepsis are highly induced at ZT11, the time of higher LPS-induced mortality, compared to ZT19.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Marpegan L,Leone MJ,Katz ME,Sobrero PM,Bekinstein TA,Golombek DAdoi
10.3109/07420520903408358subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1430-42issue
7eissn
0742-0528issn
1525-6073pii
10.3109/07420520903408358journal_volume
26pub_type
杂志文章abstract::Specific binding of [3H]-imipramine in the rat suprachiasmatic nuclei, occipital cortex and caudate putamen underwent significant and replicable changes throughout 24 hr under a light-dark cycle or under constant conditions. Daily variations were also found in the medial and dorsal raphe nuclei and the lateral hypotha...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528609066357
更新日期:1986-01-01 00:00:00
abstract::The increased prevalence of circadian disruptions due to abnormal coupling between internal and external time makes the detection of circadian phase in humans by ambulatory recordings a compelling need. Here, we propose an accurate practical procedure to estimate circadian phase with the least possible burden for the ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.820740
更新日期:2014-02-01 00:00:00
abstract::The specific circadian role proposed for endogenous melatonin production was based on a study of sighted people who took low pharmacological doses (500 microg) of this chemical signal for the "biological night": the magnitude and direction of the induced phase shifts were dependent on what time of day exogenous melato...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520500398064
更新日期:2005-01-01 00:00:00
abstract::Changes in rectal temperature during mild exercise in the middle of the rising (11:00 h) and falling (23:00 h) phases of the circadian rhythm of resting core temperature have been compared. Seven healthy males were studied at rest, while exercising on a cycle ergometer (60 min at 80 W), and during the first 30 min of ...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章
doi:10.1080/07420520601142551
更新日期:2007-01-01 00:00:00
abstract::Light-at-night (LAN) is a worldwide problem co-distributed with breast cancer prevalence. We hypothesized that exposure to LAN is coincided with a decreased melatonin (MLT) secretion level, followed by epigenetic modifications and resulted in higher breast cancer tumors growth-rate. Accordingly, we studied the effect ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.842925
更新日期:2014-02-01 00:00:00
abstract::The pineal hormone melatonin is potentially useful in the treatment of disorders, especially sleep disorders, associated with circadian rhythm disturbance. We have examined its effects on sleep, mood, and behaviour in a double-blind, placebo-controlled study of a small group of police officers working spans of seven s...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章
doi:10.3109/07420529309064485
更新日期:1993-10-01 00:00:00
abstract::Biological clock components have been detected in many epithelial tissues of the digestive tract of mammals (oral mucosa, pancreas, and liver), suggesting the existence of peripheral circadian clocks that may be entrainable by food. Our aim was to investigate the expression of main peripheral clock genes in colonocyte...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520500395011
更新日期:2005-01-01 00:00:00
abstract::Circadian changes in activities and electrophoretic pattern of the intestinal brushborder enzymes alkaline phosphatase (EC 3.1.3.1), isomaltase (EC 3.2.1.10) and sucrase (EC 3.2.1.26) of normal rats and of rats with a lesion of the dorsomedial hypothalamus (DMH-rats) were studied. In contrast to the rhythm found in no...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528509055548
更新日期:1985-01-01 00:00:00
abstract::Previous studies have demonstrated seasonal variation in the incidence of acute myocardial infarction (AMI) with an increase in cases during the winter months. However, they did not assess whether ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI) exhibit similar changes. The object of this study was to compare ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701800611
更新日期:2007-01-01 00:00:00
abstract::We evaluated their circadian rhythms using data from electrocardiographic records and examined the change in circadian period related to normal RR intervals for astronauts who completed a long-term (≥6-month) mission in space. The examinees were seven astronauts, five men and two women, from 2009 to 2010. Their mean ±...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.979940
更新日期:2015-04-01 00:00:00
abstract::Eight diurnally active (approximately 0730-1100 hr) adults (41-61 yr) suffering from nocturnal asthma volunteered for a double-blind, cross-over randomized study of a once-daily dosing (600-900 mg/24 hr) of Armophylline (Rorer s.a., France), a sustained-release theophylline given either at 0800 hr or 2000 hr for 8-day...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07420528709083530
更新日期:1987-01-01 00:00:00
abstract::Corticosterone levels were determined in the 7-week-old male rat maintained under different feeding and lighting schedules. At 4 weeks of age, the animals were kept either under a natural photoperiod (LD) or were subjected to continuous illumination (LL). Access to food was either ad libitum or restricted to an 8 hr s...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528409063909
更新日期:1984-01-01 00:00:00
abstract::Total sleep deprivation (TSD) is known to impair sustained attention. However, previously reported effects of TSD on response inhibition are mixed. We administered a "stop-signal" variation of the psychomotor vigilance test, which included 25% of trials requiring withholding of a response to assess response inhibition...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1811718
更新日期:2020-08-25 00:00:00
abstract::The circadian clock regulates the daily rhythms of several physiological and behavioral processes. Disruptions in clock genes have been associated with obesity and related comorbidities. This study aimed to analyze the association of DNA methylation signatures at circadian rhythm pathway genes with body mass index (BM...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1446021
更新日期:2018-07-01 00:00:00
abstract::In situ growth of Sphagnum riparium Ångstr. shoots were monitored during the 2015 and 2016 growing seasons in Karelia, Russia. It was established that shoot growth rates fluctuated with a period of around 30 days, that is, showed a circatrigintan rhythm. Such rhythms from mosses have not been previously reported. Corr...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1329208
更新日期:2017-01-01 00:00:00
abstract::Social anxiety has recently been linked to morningness-eveningness; however, the psychological mechanisms underlying this relationship are not well known. As such, the purpose of the current study is to propose a model by which morningness-eveningness is related to social anxiety symptoms through punishment sensitivit...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1529679
更新日期:2019-02-01 00:00:00
abstract::The intrinsic circadian clock requires photoentrainment to synchronize the 24-hour solar day. Therefore, light stimulation is an important component of chronobiological research. Currently, the chronobiological research field overwhelmingly uses photopic illuminance that is based on the luminous efficiency function, V...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.966269
更新日期:2015-03-01 00:00:00
abstract::Bone sarcomatous cells derived from human malignant tumors were cultured. The mitotic index was recorded for 39 hr. When the cultured cells originated from patients with cancer disease before any chemotherapy, ultradian mitotic rhythms of a 6-9-hr period were detected, but in many cases only after a sensitive statisti...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528909064628
更新日期:1989-01-01 00:00:00
abstract::Morningness-eveningness (chronotype) indicates the preferred time of intellectual and physical activity. This cross-sectional study had two main aims. The first aim was to explore associations among chronotype, quality of life, and relationship quality. The second aim of this study was to examine whether the similarit...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1802289
更新日期:2020-12-01 00:00:00
abstract::During a 7-10 day span, circadian rhythms of sleep-wake, self-rated fatigue and mood, oral temperature, eye-hand skill and right and left hand grip strength were investigated in eight subjects: five males (21-28 years of age), members of the French sabre fencing team selected for the 1984 Olympic Games in Los Angeles,...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528509055559
更新日期:1985-01-01 00:00:00
abstract::Ceftazidime, a third-generation cephalosporin, is widely used for the treatment of Pseudomonas aeruginosa infections. The aims of the present study were to characterize the pharmacokinetics of ceftazidime and to estimate the T > MIC against P. aeruginosa, after its intramuscular (i.m.) administration at two different ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420521003664239
更新日期:2010-05-01 00:00:00
abstract::Current evidence suggests that acute depression is associated with reduced total hippocampal volume and regional atrophy. Here, using structural magnetic resonance imaging, we assayed linear effects of chronotype on total hippocampal volume and morphology. Later chronotype was associated with localised atrophy in the ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1455056
更新日期:2018-07-01 00:00:00
abstract::Hyperphosphatemia is a common complication of chronic kidney disease (CKD) and is associated with cardiovascular disease (CVD), which has contributed to an increase in mortality of CKD patients. The onset of CVD often varies by time-of-day. Acute myocardial infarction or ventricular arrhythmia occurs most frequently d...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1486850
更新日期:2018-09-01 00:00:00
abstract::The aim of the present study was to test whether serum concentrations of leptin in ewes vary with a daily rhythm. For this purpose, we examined 24 h serum leptin profiles of ewes exposed to natural photoperiodic conditions and subjected to two different feeding schedules (regular feeding and fasting). The results show...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520500262989
更新日期:2005-01-01 00:00:00
abstract::In young healthy subjects salmon calcitonin (SCT), intranasally administered, increased in serum as a function of the drug administration time. The serum concentration of a 400 IU SCT dose monitored 10 min after dosing was statistically more significant when inhaled at 0000 than at other, more conventional, administra...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528809079555
更新日期:1988-01-01 00:00:00
abstract::Light and temperature cycles are the most important synchronizers of biological rhythms in nature. However, the relative importance of each, especially when they are not in phase, has been poorly studied. The aim of this study was to analyze the entrainment of daily locomotor activity to light and/or temperature cycle...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520600651065
更新日期:2006-01-01 00:00:00
abstract::Most research papers published in Chronobiology International report the findings of investigations conducted on laboratory animals and human beings. The Journal, its editors and the publication committee endorse the compliance of investigators to the principles of the Declaration of Helsinki of the World Medical Asso...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120030045
更新日期:2004-01-01 00:00:00
abstract::In the current study, we studied behavioral patterns, such as foraging, activity, standing, and laying in a population of cattle wandering on streets of Raipur city. We also determined the effects of four environmental factors (temperature, humidity, light, and noise intensities) on these behaviors. We recorded all fo...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1644345
更新日期:2019-10-01 00:00:00
abstract::A variable number tandem repeat polymorphism (VNTR) in the period 3 (PER3) gene has been associated with heritable sleep and circadian variables, including self-rated chronotypes, polysomnographic (PSG) variables, insomnia and circadian sleep-wake disorders. This report describes novel molecular and clinical analyses ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1287083
更新日期:2017-01-01 00:00:00
abstract::The organizing committee of the 2016 Rio Olympic Games recently announced that some of the preliminary and final competitions will be held at night. The present article discusses the potential harmful effects of these late-night competitions on sleep, circadian rhythms and athletic performance during the Olympic Games...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2016.1150290
更新日期:2016-01-01 00:00:00