Influence of a dorsomedial hypothalamus lesion on the circadian changes in the enzyme development and activity of intestinal brushborder membranes in the rat.

Abstract:

:Circadian changes in activities and electrophoretic pattern of the intestinal brushborder enzymes alkaline phosphatase (EC 3.1.3.1), isomaltase (EC 3.2.1.10) and sucrase (EC 3.2.1.26) of normal rats and of rats with a lesion of the dorsomedial hypothalamus (DMH-rats) were studied. In contrast to the rhythm found in normal rats, there are no significant differences between the average enzyme activities in the light or dark period for the DMH-rats. The peak ratio in the electrophoretic pattern for sucrase-isomaltase (SI) over pro-sucrase-isomaltase (pro-SI) changes over 24 hr with higher values during the active (dark) period of the normal rat. In DMH-rats this ratio is much higher, but no significant difference could be demonstrated between the values near the acrophase in these rats.

journal_name

Chronobiol Int

authors

Hekkens WT,van Rijn PA,Lukac-Bajalo J,Ungerer R,Rietveld WJ

doi

10.3109/07420528509055548

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

103-8

issue

2

eissn

0742-0528

issn

1525-6073

journal_volume

2

pub_type

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