Abstract:
:In young healthy subjects salmon calcitonin (SCT), intranasally administered, increased in serum as a function of the drug administration time. The serum concentration of a 400 IU SCT dose monitored 10 min after dosing was statistically more significant when inhaled at 0000 than at other, more conventional, administration times (morning or evening). Following dosing at certain times during the day, the serum SCT was less or even questionable with the dose and under the study conditions selected. Dosing without consideration of timing may lead to reduced effect or lack of effect or perhaps ambiguity or controversy regarding the possible circumstance of a "non-absorbent subject". The circadian frequency appears to be a critical determinant of intranasal SCT absorption suggesting administration time to be an important factor in the cost/benefit ratio without the unpleasant side effects sometimes experienced through parenteral routes.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Tarquini B,Cavallini V,Cariddi A,Checchi M,Sorice V,Cecchettin Mdoi
10.3109/07420528809079555subject
Has Abstractpub_date
1988-01-01 00:00:00pages
149-52issue
2eissn
0742-0528issn
1525-6073journal_volume
5pub_type
杂志文章abstract::The effects of Chagas disease on the mammalian circadian system were studied in Trypanosoma cruzi-infected C57-B16J mice. Animals were inoculated with CAI or RA strains of T. cruzi or vehicle, parasitism confirmed by blood specimen visualization and locomotor activity rhythms analyzed by wheel-running recording. RA-st...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120017687
更新日期:2003-01-01 00:00:00
abstract::The objectives of the study were to investigate the associations between night work and disability pension (DP) due to all causes, cardiovascular (CVD), mental, and other diagnoses, adjusting for familial confounding. The material of the study included comprehensive survey data on 27 165 Swedish twins born in 1935-195...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1399137
更新日期:2018-02-01 00:00:00
abstract::Twenty-four different laboratory parameters including the phagocytic activity (phagocytic index) of polymorphonuclear leukocytes (PMNs) and various hematologic variables were investigated in 13 young healthy men during Spring 1988 in Munich, Germany. Venous blood of these volunteers was obtained under standardized con...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529209064514
更新日期:1992-01-01 00:00:00
abstract::Due to personal and working necessities, the time for exercise is often short, and scheduled early in the morning or late in the afternoon. Cortisol plays a central role in the physiological and behavioral response to a physical challenge and can be considered as an index of exercise stress. Therefore, the aim of this...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1311336
更新日期:2017-01-01 00:00:00
abstract::A physiological dose of orally administered melatonin shifts circadian rhythms in humans according to a phase-response curve (PRC) that is nearly opposite in phase with the PRCs for light exposure: melatonin delays circadian rhythms when administered in the morning and advances them when administered in the afternoon ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529209064550
更新日期:1992-10-01 00:00:00
abstract::The aim of the study was to evaluate the influence of chronotype (morning-type versus evening-type) living in a fixed sleep-wake schedule different from one's preferred sleep schedules on the time course of neurobehavioral performance during controlled extended wakefulness. The authors studied 9 morning-type and 9 eve...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.590623
更新日期:2011-07-01 00:00:00
abstract::The influence of environmental (extracellular) pH on the sporulation rhythm in Neurospora crassa was investigated for wild-type (frq+) and the mutants chr, frq1, frq7, and frq8. In all mutants, including wild type, the growth rate was found to be influenced strongly by extracellular pH in the range 4-9. On the other h...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100102109
更新日期:2000-11-01 00:00:00
abstract::Fabry disease is a progressive disease characterized by an enzymatic deficiency of acid alpha-galactosidase and glycosphingolipids storage within the lysosomes. The disease has two phenotypes: classic and nonclassic. Excessive daytime sleepiness is a common sign reported by patients and can be caused by a circadian rh...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1560308
更新日期:2019-04-01 00:00:00
abstract::The 10 min psychomotor vigilance task (PVT) is commonly used in laboratory studies to assess the impact of sleep loss, sustained wakefulness, and/or time of day on neurobehavioral performance. In field settings, though, it may be impractical for participants to perform a test of this length. The aim of this study was ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520601067931
更新日期:2006-01-01 00:00:00
abstract::In Channa punctatus, a significant daily variation in hypothalamic 5-HT level and monoamine oxidase (MAO) activity was noticed in preparatory phase (February), but not in prespawning (May) or postspawning (November) phases. Hypothalamic dopamine (DA) and noradrenaline (NA), on the other hand, showed marked daily varia...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528809067776
更新日期:1988-01-01 00:00:00
abstract::This article reviews the experimental and clinical data that form the basis for the chronotherapy of lung carcinoma, specifically, nonsmall cell lung cancer (NSCLC). Circadian rhythms in cell kinetics, immunological and endocrinological endpoints, and tumor markers are reviewed. Chronopharmacology and chronotolerance ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-120002601
更新日期:2002-01-01 00:00:00
abstract::A synopsis of the effects of exercise on the circadian system in nocturnal rodents is followed by a review of the few studies investigating the influence of exercise on the human circadian system. It is premature to make specific recommendations about using exercise to promote synchronization in people because of the ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529709001157
更新日期:1997-03-01 00:00:00
abstract::Previous studies have demonstrated seasonal variation in the incidence of acute myocardial infarction (AMI) with an increase in cases during the winter months. However, they did not assess whether ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI) exhibit similar changes. The object of this study was to compare ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701800611
更新日期:2007-01-01 00:00:00
abstract::In 33 patients with heart failure (NYHA II-III), the 24-h blood pressure rhythm was examined before and after the titration period of two ACE inhibitors. Blood pressure was measured by the oscillometric method using the blood pressure monitor 90202 from SpaceLabs, Inc. The measurements were taken from 06:00 to 22:00 h...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07420529109059177
更新日期:1991-01-01 00:00:00
abstract::The objective of the present study was to evaluate seasonal periodicity in the prevalence of Helicobacter pylori. A prospective study was performed on 1076 consecutive patients who were investigated in our hospital over a 3-year span because of epigastric complaints. Our findings indicate a significant accumulation of...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529909016947
更新日期:1999-11-01 00:00:00
abstract::Daily schedules of many organisms, including birds, are thought to affect fitness. Timing in birds is based on circadian clocks that have a heritable period length, but fitness consequences for individuals in natural environments depend on the scheduling of entrained clocks. This chronotype, i.e., timing of an individ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.707159
更新日期:2012-10-01 00:00:00
abstract::The aim of this study was to investigate whether time-dependent variations in the relaxant effect of acetylcholine, an endothelium-dependent vasorelaxant via muscarinic receptors, and isoprenaline, a nonselective beta-adrenoceptor agonist in rat aorta, are influenced by streptozotocin (STZ)-induced experimental diabet...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701795332
更新日期:2007-01-01 00:00:00
abstract::In situ growth of Sphagnum riparium Ångstr. shoots were monitored during the 2015 and 2016 growing seasons in Karelia, Russia. It was established that shoot growth rates fluctuated with a period of around 30 days, that is, showed a circatrigintan rhythm. Such rhythms from mosses have not been previously reported. Corr...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1329208
更新日期:2017-01-01 00:00:00
abstract::The properties of the circadian photoperiodic oscillator have been investigated in detail only in the Japanese quail. While the study of the quail is clearly very important, one cannot simply assume that other species, especially passerines that seem to have a different circadian organization than quail, function the ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120014570
更新日期:2002-09-01 00:00:00
abstract::It has frequently been reported that exposure to artificial light at night (ALAN) may cause negative health effects, such as breast cancer, circadian phase disruption and sleep disorders. Here, we reviewed the literature assessing the effects of human exposure to ALAN in order to list the health effects of various asp...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420528.2015.1073158
更新日期:2015-01-01 00:00:00
abstract::Total sleep deprivation (TSD) is known to impair sustained attention. However, previously reported effects of TSD on response inhibition are mixed. We administered a "stop-signal" variation of the psychomotor vigilance test, which included 25% of trials requiring withholding of a response to assess response inhibition...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1811718
更新日期:2020-08-25 00:00:00
abstract::Visual sensitivity rhythm has been assessed by several authors in animals. It shows an intrinsic circadian rhythm of some retinal mechanisms that could account for fluctuating sensitivity to light during the day in these species. However, very little is known concerning a possible circadian rhythm of visual sensitivit...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529709040540
更新日期:1997-01-01 00:00:00
abstract::Individual differences in time of day preference have important correlates. Morningness is associated with greater well-being, while eveningness is associated with more maladaptive behaviors, psychological distress, and disorder. The availability of valid, reliable, questionnaire scales is central to this ongoing rese...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1608225
更新日期:2019-08-01 00:00:00
abstract::We analyzed the association between change in work schedule and modifications in nutritional status. We performed a panel study with nursing professionals based on two surveys seven year apart (n = 372). Groups with no change in work schedule, change from daytime to night shift, and change from night to daytime shift ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2016.1167719
更新日期:2016-01-01 00:00:00
abstract::Police officers are required to work irregular hours, which induces stress, fatigue, and sleep disruption, and they have higher rates of chronic disease and mortality. Cortisol is a well-known "stress hormone" produced via activation of the hypothalamic-pituitary-adrenal axis. An abnormal secretion pattern has been as...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.573112
更新日期:2011-05-01 00:00:00
abstract::In order to optimize chronotherapeutic schedules (designs), we examined the interindividual differences in chronopharmacologic effects of drugs with consideration of the following three factors: (a) inherited factors of direct relevance to chronopharmacology (genetic variability, gender-related differences) as well as...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529309059721
更新日期:1993-12-01 00:00:00
abstract::Seasonal variations have been described in humans in several variables such as sleep, mood, appetite, food preferences, or body weight. We hypothesized that these variations could also influence the decrease in body weight rate in patients submitted to body weight loss interventions. Thus, here we tested the variation...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1580716
更新日期:2019-05-01 00:00:00
abstract::Several substances change the period length of the circadian oscillator in the laminar pulvinus of Phaseolus coccineus L. if offered continuously via the transpiration stream to the isolated leaves in continuous light and constant temperature. The osmotica mannitol and PEG 6000 (polyethylene glycol) lengthen the circa...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528509055537
更新日期:1985-01-01 00:00:00
abstract::Various processes associated with mammalian reproduction exhibit circadian rhythms, yet no information is available concerning the presence of rhythmicity in meiosis-the crucial process of the production of sex cells. Following meiosis in cells derived from male mice exposed in vivo to daily light-dark cycles (LD), we...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529808998665
更新日期:1998-01-01 00:00:00
abstract::We evaluated their circadian rhythms using data from electrocardiographic records and examined the change in circadian period related to normal RR intervals for astronauts who completed a long-term (≥6-month) mission in space. The examinees were seven astronauts, five men and two women, from 2009 to 2010. Their mean ±...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.979940
更新日期:2015-04-01 00:00:00