The circadian system of Trypanosoma cruzi-infected mice.

Abstract:

:The effects of Chagas disease on the mammalian circadian system were studied in Trypanosoma cruzi-infected C57-B16J mice. Animals were inoculated with CAI or RA strains of T. cruzi or vehicle, parasitism confirmed by blood specimen visualization and locomotor activity rhythms analyzed by wheel-running recording. RA-strain infected mice exhibited significantly decreased amplitude of circadian rhythms, both under light-dark and constant dark conditions, probably due to motor deficiencies. CAI-treated animals showed normal locomotor activity rhythms. However, in these mice, reentrainment to a 6h phase shift of the LD cycle took significantly longer than controls, and application of 15min light pulses in DD produced smaller phase delays of the rhythms. All groups exhibited light-induced Fos expression in the suprachiasmatic nuclei. We conclude that the main effect of T. cruzi infection on the circadian system is an impairment of the motor output from the clock toward controlled rhythms, together with an effect on circadian visual sensitivity.

journal_name

Chronobiol Int

authors

Fernández Alfonso T,Celentano AM,Gonzalez Cappa SM,Golombek DA

doi

10.1081/cbi-120017687

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

49-64

issue

1

eissn

0742-0528

issn

1525-6073

journal_volume

20

pub_type

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