Abstract:
:Intense artificial light can phase-shift circadian rhythms and improve performance, sleep, and well-being during shiftwork simulations. In real shiftworkers, however, exposure to sunlight and other time cues may decrease the efficacy of light treatment, and occupational and family responsibilities may make it impractical. With these considerations in mind, we designed and tested light-treatment protocols for NASA personnel who worked on shifted schedules during two Space Shuttle missions. During the prelaunch week, treatment subjects self-administered light of approximately 10,000 lux at times of day that phase-delay circadian rhythms. Treatment continued during the missions and for several days afterward. No treatment was administered to subjects in the control group. Treatment subjects reported better sleep, performance, and physical and emotional well-being than control subjects and rated the treatment as highly effective for promoting adjustment to their work schedules. Light treatment is both feasible and beneficial for NASA personnel who must work on shifted schedules during Space Shuttle missions.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Stewart KT,Hayes BC,Eastman CIdoi
10.3109/07420529509064509subject
Has Abstractpub_date
1995-04-01 00:00:00pages
141-51issue
2eissn
0742-0528issn
1525-6073journal_volume
12pub_type
杂志文章abstract::The effects of short-term food deprivation on the serum and renal distribution and nephrotoxicity of tobramycin were studied in female Sprague-Dawley rats maintained on a 14-h light/10-h dark cycle (light on: 06:00). For the distribution study, a single injection of tobramycin (40 mg/kg, i.p.) was administered at 14:0...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529609037075
更新日期:1996-07-01 00:00:00
abstract::Flexible working hours can have several meanings and can be arranged in a number of ways to suit the worker and/or employer. Two aspects of "flexible" arrangement of working hours were considered: one more subjected to company control and decision (variability) and one more connected to individual discretion and auton...
journal_title:Chronobiology international
pub_type: 杂志文章,多中心研究
doi:10.1080/07420520601087491
更新日期:2006-01-01 00:00:00
abstract::Ninety-five nonresident girls of a private school volunteered for the study with the teachers' help as well as parental consent. Ages were approximately 8, 9, and 10 years. They were synchronized with diurnal activity from 0730 to 2100 h and nocturnal rest. Fatigue, drowsiness, and attention were self-rated using visu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529109059164
更新日期:1991-01-01 00:00:00
abstract::In order to optimize chronotherapeutic schedules (designs), we examined the interindividual differences in chronopharmacologic effects of drugs with consideration of the following three factors: (a) inherited factors of direct relevance to chronopharmacology (genetic variability, gender-related differences) as well as...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529309059721
更新日期:1993-12-01 00:00:00
abstract::A diary-based instrument-the Social Rhythm Metric (SRM)-was used to assess the level of stability of daily social and behavioral rhythms in a group of 239 healthy subjects (112 male, 127 female) ranging in age from 20 to 89 years. Each subject completed the instrument for two consecutive weeks, which were averaged to ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529709001421
更新日期:1997-05-01 00:00:00
abstract::Although there are significant intra-individual differences in self-reported diurnal preference, as measured by validated questionnaires, the relative contribution of exogenous and endogenous factors to self-reported diurnal preference largely remains to be investigated. The present study examined which items from the...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520902820970
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Morning stiffness and plasma cytokine levels in rheumatoid arthritis (RA) patients exhibit 24-hour variations. Tumor necrosis factor-α (TNF-α) plays a central role in RA clinical conditions, including the invasion of inflammatory cells, destruction of cartilage, systemic inflammatory response and its levels s...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.878350
更新日期:2014-05-01 00:00:00
abstract::The ventromedial hypothalamic nucleus (VMH) regulates various autonomic, endocrine, and behavioral activities. These activities show annual changes, and the pineal gland is involved in their adjustment to environmental cues. Therefore, this study investigated whether the VMH belongs to the effector structures of the p...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100101028
更新日期:2000-01-01 00:00:00
abstract::The 3111T/C single nucleotide polymorphism (SNP) of Circadian Locomotor Output Cycles Kaput (CLOCK) gene reportedly affects gastric motility before breakfast. It is of interest to know whether this SNP can affect the motility during the daytime. We investigated the association between the CLOCK 3111T/C SNP and several...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1373660
更新日期:2017-01-01 00:00:00
abstract::A variable number tandem repeat polymorphism (VNTR) in the period 3 (PER3) gene has been associated with heritable sleep and circadian variables, including self-rated chronotypes, polysomnographic (PSG) variables, insomnia and circadian sleep-wake disorders. This report describes novel molecular and clinical analyses ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1287083
更新日期:2017-01-01 00:00:00
abstract::We aimed to study the association of perceived control over scheduling of shifts with objectively measured working hour characteristics in shift workers. The participants were 5128 hospital employees (91% women, 85% nursing personnel, average age 43 years) in period-based work (114:45h/3 weeks) from the 2015 Finnish P...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1520240
更新日期:2019-01-01 00:00:00
abstract::The circadian melatonin rhythm is highly reproducible and generally not easily altered. The few perturbations that are capable of significantly changing either the amplitude or the pattern of the 24-h melatonin rhythm are summarized herein. Aging alters cyclic melatonin production by decreasing the amplitude of the no...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529209064541
更新日期:1992-08-01 00:00:00
abstract::Multiple components of the circadian central clock are phosphoproteins, and it has become increasingly clear that posttranslational modification is an important regulator of circadian rhythm in diverse organisms, from dinoflagellates to humans. Genetic studies in Drosophila have identified double-time (dbt), a serine/...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-100103963
更新日期:2001-05-01 00:00:00
abstract::The present study was designed to investigate the effect of Ramadan fasting on feelings, dietary intake, rating of perceived exertion (RPE) and repeated high-intensity short-term maximal performance. Thirteen physically active men (age: 21.2 ± 2.9 years, height: 175.6 ± 5.6 cm, body-mass: 72.4 ± 8.6 kg) performed a 5-...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1513943
更新日期:2019-01-01 00:00:00
abstract::In amphibians, voltage-gated sodium (Nav) channels in cone ON bipolar cells (ON-CBC) amplify cone signals in the dark and in mesopic background light. However, during light adaptation, dopamine, acting through D1 receptors (D1R), suppresses Nav channels and therefore act as a gain control mechanism. Curiously in roden...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.951054
更新日期:2015-02-01 00:00:00
abstract::The course of swelling after maxillo-facial surgery was investigated by measuring the distance from the tragus to the pogonium. The post-surgical swelling does not diminish continuously, but decreases in a circaseptan periodic mode. The reactive periodicity is preferentially induced not by the injury, but by the surgi...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528409059133
更新日期:1984-01-01 00:00:00
abstract::In Channa punctatus, a significant daily variation in hypothalamic 5-HT level and monoamine oxidase (MAO) activity was noticed in preparatory phase (February), but not in prespawning (May) or postspawning (November) phases. Hypothalamic dopamine (DA) and noradrenaline (NA), on the other hand, showed marked daily varia...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528809067776
更新日期:1988-01-01 00:00:00
abstract::The mammalian central pacemaker, driving circadian rhythms in behavior, physiology, and metabolism, is located in the suprachiasmatic nuclei (SCN) of the hypothalamus. At the molecular level circadian clocks are based on a system of transcriptional/translational feedback loops oscillating with a period of about 24h. I...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120022408
更新日期:2003-07-01 00:00:00
abstract::Specific binding of [3H]-imipramine in the rat suprachiasmatic nuclei, occipital cortex and caudate putamen underwent significant and replicable changes throughout 24 hr under a light-dark cycle or under constant conditions. Daily variations were also found in the medial and dorsal raphe nuclei and the lateral hypotha...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528609066357
更新日期:1986-01-01 00:00:00
abstract::Influences of starvation, re-feeding and time of food supply on daily rhythm features of melatonin (5-methoxy-N-acetyltryptamine) and its key regulator AANAT (arylalkylamine N-acetyltransferase) protein in the gut tissues were separately evaluated in carp Catla catla. The first experiment was aimed at demonstration of...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1087020
更新日期:2015-01-01 00:00:00
abstract::Patients with resistant hypertension (RH) are at greater risk for stroke, renal insufficiency, and cardiovascular disease (CVD) events than are those for whom blood pressure (BP) is responsive to and well controlled by therapeutic interventions. Although all chronotherapy trials have compared the effects on BP regulat...
journal_title:Chronobiology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/07420528.2012.701460
更新日期:2013-03-01 00:00:00
abstract::A double-blind randomized parallel-group trial was undertaken to evaluate the influence of the dosing time of sustained-release ketoprofen (SRK) on its acceptability and efficacy. The SRK was prescribed for 2 weeks (200 mg once a day) to 117 outpatients with osteoarthritis of the knee and/or hip. One group received SR...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07420529409055898
更新日期:1994-04-01 00:00:00
abstract::The effect of altitude on four basic properties of the pacemaker controlling the circadian rhythm of oviposition in two strains of Drosophila ananassae was determined. The high altitude (HA) strain from Badrinath (5123 m above sea level) had a low amplitude peak in the forenoon while the low altitude (LA) strain from ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-200030508
更新日期:2005-01-01 00:00:00
abstract::Recently, we found that the reactivity of ambulatory blood pressure (BP) to everyday physical activities is highest in the morning. All participants in that study slept normally at night and freely chose their activity levels, which did not allow a separation of any circadian influence on the BP response from the effe...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520802548044
更新日期:2008-11-01 00:00:00
abstract::Acute thrombotic events frequently occur in the early morning among hyperlipidemic patients. The activity of plasminogen activator inhibitor-1 (PAI-1), a potent inhibitor of the fibrinolytic system, oscillates daily, and this is considered one mechanism that underlies the morning onset of acute thrombotic events in hy...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2010.515324
更新日期:2010-10-01 00:00:00
abstract::Circadian rhythms are still expressed in animals that display daily torpor, implying a temperature compensation of the pacemaker. Nevertheless, it remains unclear how the clock works in hypothermic states and whether torpor itself, as a temperature pulse, affects the circadian system. To reveal changes in the clockwor...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520500522424
更新日期:2006-01-01 00:00:00
abstract::One of the supposed mechanisms that may lead to breast cancer (BC) is an alteration of circadian gene expression and DNA methylation. We undertook an integrated approach to identify methylation pattern of core circadian promoter regions in BC patients with regard to clinical features. We performed a quantitative methy...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1617732
更新日期:2019-08-01 00:00:00
abstract::Phase-response experiments using 1-h light pulses (LPs) of 1,100 lux applied under constant dim light of 0.3 lux were conducted with common marmosets, Callithrix j. jacchus, in order to obtain a complete phase-response curve established according to the common experimental procedure in a diurnal primate. Maximal phase...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529409057243
更新日期:1994-10-01 00:00:00
abstract::The circalunidian-clock hypothesis is a formulation describing the means by which the tide-associated rhythms of intertidal organisms are generated. The postulate was described in a 1995 article in this journal (12:299-310). A recent paper published here (13:153-62) by Prof. Ernest Naylor challenges the validity of th...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529709001455
更新日期:1997-07-01 00:00:00
abstract::The aims of this study were to examine the genetic and environmental influences on diurnal preference and sleep quality, the association between these phenotypes, the genetic and environmental influences on this association, and the magnitude of overlap between these influences. Using a twin design, data on diurnal pr...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420521003663801
更新日期:2010-01-01 00:00:00