Abstract:
:Multiple components of the circadian central clock are phosphoproteins, and it has become increasingly clear that posttranslational modification is an important regulator of circadian rhythm in diverse organisms, from dinoflagellates to humans. Genetic studies in Drosophila have identified double-time (dbt), a serine/threonine protein kinase that is highly homologous to human casein kinase I epsilon (CKIepsilon), as the first kinase linked to behavioral rhythms. Identification of a missense mutation in CKIepsilon as the tau mutation in the Syrian hamster places CKIepsilon within the core clock machinery in mammals. Most recently, identification of a phosphorylation site mutant of hPER2 in a family with an inherited circadian rhythm abnormality strongly suggests that PER2 is a physiologically relevant substrate of CKI. Phosphorylation may regulate multiple properties of clock proteins, including stability and intracellular localization.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Eide EJ,Virshup DMdoi
10.1081/cbi-100103963subject
Has Abstractpub_date
2001-05-01 00:00:00pages
389-98issue
3eissn
0742-0528issn
1525-6073journal_volume
18pub_type
杂志文章,评审abstract::Diurnal and seasonal rhythms of cortisol, testosterone, and DHEA were examined, as little is known about the relationship between these rhythmicities and pubertal development. Salivary samples were obtained from 60 boys and 60 girls at approximately 07:45, 08:00, 08:30, 12:00, 16:50, and 21:00 h. The participants' age...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701649471
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:Morning stiffness and plasma cytokine levels in rheumatoid arthritis (RA) patients exhibit 24-hour variations. Tumor necrosis factor-α (TNF-α) plays a central role in RA clinical conditions, including the invasion of inflammatory cells, destruction of cartilage, systemic inflammatory response and its levels s...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.878350
更新日期:2014-05-01 00:00:00
abstract::The circadian clock of man and mammals shows a hierarchic organization. The master clock, located in the suprachiasmatic nuclei (SCN), controls peripheral oscillators distributed throughout the body. Rhythm generation depends on molecular clockworks based on transcriptional/translational interaction of clock genes. Nu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.949735
更新日期:2015-02-01 00:00:00
abstract::The effects of Chagas disease on the mammalian circadian system were studied in Trypanosoma cruzi-infected C57-B16J mice. Animals were inoculated with CAI or RA strains of T. cruzi or vehicle, parasitism confirmed by blood specimen visualization and locomotor activity rhythms analyzed by wheel-running recording. RA-st...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120017687
更新日期:2003-01-01 00:00:00
abstract::In previous experiments, we found that rats raised in constant light (LL) manifested a more robust circadian rhythm of motor activity in LL and showed longer phase shifts after a light pulse in constant darkness (DD) than chose raised under constant darkness. In addition, we observed that the effects produced by const...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100106081
更新日期:2001-07-01 00:00:00
abstract::The objective of the present study was to evaluate the sexual behavior of male rats kept under constant laboratory conditions for one entire year. A total of 213 sexually-inexperienced, male Wistar rats were maintained in controlled environmental conditions from birth. Depending the month in which they reached the age...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1715997
更新日期:2020-02-01 00:00:00
abstract::Populations working night shift are high risk for diet-related chronic illness which may result from circadian misalignment. Studies documenting nutritional habits among night shift workers have relied on inaccurate approximations of dietary intake. The primary purpose of this pilot study was to gather feasibility inf...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1822857
更新日期:2020-09-28 00:00:00
abstract::The present article analyzes locomotor activity rhythms in Tinca tinca. To that end, three different experiments were conducted on 24 animals (20 g body weight) kept in pairs in 60-liter aquaria fitted with infrared sensors connected to a computer to continuously record fish movements. The first experiment was designe...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120025246
更新日期:2003-11-01 00:00:00
abstract::Circadian rhythms in mammals are adjusted daily to the environmental day/night cycle by photic input via the retinohypothalamic tract (RHT). Retinal ganglion cells (RGCs) of the RHT constitute a separate light-detecting system in the mammalian retina used for irradiance detection and for transmission to the circadian ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520500464544
更新日期:2006-01-01 00:00:00
abstract::Loratadine is a second-generation histamine H(1)-receptor antagonist used in the treatment of allergic diseases. The aim of the study was to assess whether lethal toxicity and motor incoordination (neurotoxicity) of loratadine is circadian rhythm-dependent. A total of 210 male Swiss mice, aged 10 wk, were synchronized...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/CBI-200062369
更新日期:2005-01-01 00:00:00
abstract::Career decisions are based on the fit between an individual and his/her environment. This study explores the effect of person-environment fit regarding actual and preferred weekly working hours on early and late retirement intentions in a sample of 7,859 employees aged 50 to 65 years of age living in Germany. Findings...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1806291
更新日期:2020-08-24 00:00:00
abstract::The aims of this study were to examine the genetic and environmental influences on diurnal preference and sleep quality, the association between these phenotypes, the genetic and environmental influences on this association, and the magnitude of overlap between these influences. Using a twin design, data on diurnal pr...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420521003663801
更新日期:2010-01-01 00:00:00
abstract::Sleep and fatigue-associated symptoms are prominent during chemotherapy. The purpose of this pilot study was to examine bright light effects on sleep disruption, fatigue, daytime sleepiness, depression, and quality of life (QOL) in women with stage I-III breast cancer undergoing chemotherapy. In this 2-group randomize...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2021.1871914
更新日期:2021-01-21 00:00:00
abstract::In Drosophila circadian rhythms persist in constant darkness (DD). The small ventral Lateral Neurons (s-LNv) mainly control the behavioral circadian rhythm in consortium with the large ventral Lateral Neurons (l-LNv) and dorsal Lateral Neurons (LNd). It is believed that the molecular oscillations of clock genes are th...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-120038597
更新日期:2004-05-01 00:00:00
abstract::Circadian changes in activities and electrophoretic pattern of the intestinal brushborder enzymes alkaline phosphatase (EC 3.1.3.1), isomaltase (EC 3.2.1.10) and sucrase (EC 3.2.1.26) of normal rats and of rats with a lesion of the dorsomedial hypothalamus (DMH-rats) were studied. In contrast to the rhythm found in no...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528509055548
更新日期:1985-01-01 00:00:00
abstract::The aim of this study was to demonstrate that a possible recurrence may pertain to migraine attacks (MAs). The study was carried out by checking the personal diaries of 30 migraine sufferers ("migraineurs") who carefully annotated the date of their MA over twelve consecutive months. The group was composed of 15 males ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529009059158
更新日期:1990-01-01 00:00:00
abstract::Shift workers are known to have an increased risk of developing cardiovascular disease (CVD) compared with day workers. An important factor contributing to this increased risk could be the increased incidence of postprandial metabolic risk factors for CVD among shift workers, as a consequence of the maladaptation of e...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1081/cbi-200037171
更新日期:2004-01-01 00:00:00
abstract::Previous studies have reported sex differences in the pathophysiology of hypertension and responses to blood pressure (BP)-lowering medications. Moreover, men exhibit typically higher BP than women, the differences being greater for systolic (SBP) than diastolic (DBP) BP. These differences become apparent during adole...
journal_title:Chronobiology international
pub_type: 杂志文章,随机对照试验
doi:10.3109/07420528.2012.701487
更新日期:2013-03-01 00:00:00
abstract::The objective of this study was to determine in a significant temporal pattern exists in the presentation of sickle cell vaso-occlusive pain crisis (SC-VPC) patients to an emergency department (ED) for treatment. This 28-month retrospective study of ED sickle cell crisis treatment involved 1128 presumably diurnally ac...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529609020915
更新日期:1996-12-01 00:00:00
abstract::Intolerance to shift work may result from individual susceptibility to an internal desynchronization. Some shift workers (SW) who show desynchronization of their circadian rhythms (e.g., sleep-wake, body temperature, and grip strength of both hands) exhibit symptoms of SW intolerance, such as sleep alteration, persist...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520802256101
更新日期:2008-07-01 00:00:00
abstract::Acute thrombotic events frequently occur in the early morning among hyperlipidemic patients. The activity of plasminogen activator inhibitor-1 (PAI-1), a potent inhibitor of the fibrinolytic system, oscillates daily, and this is considered one mechanism that underlies the morning onset of acute thrombotic events in hy...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2010.515324
更新日期:2010-10-01 00:00:00
abstract::Disruption of circadian rhythms, which frequently occurs during night shift work, may be associated with cancer progression. The effect of chronotype (preference for behaviors such as sleep, work, or exercise to occur at particular times of day, with an associated difference in circadian physiology) and alignment of b...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.842575
更新日期:2014-03-01 00:00:00
abstract::It was previously shown that there is seasonality in the amount of dietary carbohydrate not absorbed from the intestine after breakfast, the amount of carbohydrate in winter being significantly larger than that in autumn in young Japanese subjects. In order to investigate this phenomenon further, the experiment was re...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701531166
更新日期:2007-01-01 00:00:00
abstract::Daily variation in the absorption, metabolism and excretion of toxic substances will ultimately determine the actual concentration to which the cells and tissues are exposed. In aquaculture, Atlantic salmon (Salmo salar) can be frequently exposed to hydrogen peroxide (H2O2) to treat topical skin and gill infections, p...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1131164
更新日期:2016-01-01 00:00:00
abstract::Circadian rhythms in plants are liable to masking, i.e. alterations by environmental influencing agents. Experiments have been reported for both positive and negative masking, attributed to a Zeitgeber which may either increase or decrease the amplitude of a circadian rhythm (CR). In some instances, the CR may even be...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528909059138
更新日期:1989-01-01 00:00:00
abstract::The length of the free-running period (τ) affects how an animal re-entrains after phase shifts of the light-dark (LD) cycle. Those with shorter periods adapt faster to phase advances than those with longer periods, whereas those with longer periods adapt faster to phase delays than those with shorter periods. The free...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.700670
更新日期:2012-10-01 00:00:00
abstract::Depression is a multifactorial illness that is highly prevalent among medical students (MS). Chronotypes, which reflect circadian preference in humans, as well as academic stress have been associated with depression in different populations. However, it is not known how chronotype and stress might alone or in combinat...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2016.1217230
更新日期:2016-01-01 00:00:00
abstract::In two experiments, triazolam (2.5 and 1.5 mg/animal) failed to significantly enhance the rate of reentrainment of hamsters (Mesocricetus auratus) to an 8-hr advance of their light-dark cycle. Evidently the phase-shifting effects of triazolam are not robust. The animals did not run much in their wheels in response to ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529009056952
更新日期:1990-01-01 00:00:00
abstract::Previous studies have demonstrated seasonal variation in the incidence of acute myocardial infarction (AMI) with an increase in cases during the winter months. However, they did not assess whether ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI) exhibit similar changes. The object of this study was to compare ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701800611
更新日期:2007-01-01 00:00:00
abstract::The objectives of the study were to investigate the associations between night work and disability pension (DP) due to all causes, cardiovascular (CVD), mental, and other diagnoses, adjusting for familial confounding. The material of the study included comprehensive survey data on 27 165 Swedish twins born in 1935-195...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1399137
更新日期:2018-02-01 00:00:00