Abstract:
:Daily variation in the absorption, metabolism and excretion of toxic substances will ultimately determine the actual concentration to which the cells and tissues are exposed. In aquaculture, Atlantic salmon (Salmo salar) can be frequently exposed to hydrogen peroxide (H2O2) to treat topical skin and gill infections, particularly in relation to parasitic infections (e.g. sea lice Lepeophtheirus salmonis and amoebic gill disease caused by Neoparamoeba perurans). It is well accepted that the time of administration influences pharmacodynamics and pharmacokinetics of drugs which in turn affects their efficacy and toxicity. Consequently, a better understanding of drug side effects as a function of time of day exposure would help to improve treatment efficacy and fish welfare. To this end, salmon were exposed to H2O2 (1500 mg/L) for 20 min at six different times of the day during a 24-h cycle and we investigated the time-dependent effects of exposure on physiological stress (glucose, lactate and cortisol) and antioxidant enzyme expression (gpx1, cat, Mn-sod and hsp70) in liver and gills. In addition, at each sampling point, 8 control fish were also sampled. Our results revealed that the time of administration of H2O2 caused significant differences in the induction of both physiological and oxidative stress responses. Glucose and lactate were higher in the treated fish during daytime whereas cortisol levels appeared to be systematically increased (>1000 ng/mL) after H2O2 treatment irrespective of exposure time, although differences with control levels were higher during the day. In liver, gene expression of antioxidant enzymes displayed daily rhythmicity in both treated and control groups and showed higher mRNA expression levels in salmon treated with H2O2 at ZT6 (6 h after lights onset). In gills, rhythmic expression was only found for gpx1 in the control fish and for hsp70 and Mn-sod in the treated groups. However, in the treated salmon, higher gene expression levels of all the investigated enzymes were also observed at ZT6-10. Clock gene expression showed rhythmicity only in the liver in accordance with the daily rhythm of enzyme expression observed in this tissue. Altogether, this study provides first evidence of chronotoxicity in Atlantic salmon treated with H2O2 and suggests increased sublethal toxic effect during the first half of the day. These results have direct relevance to the salmon and broader aquaculture industry by optimising the timing of treatment administration, opening the door to chronotherapy to treat fish diseases.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Vera LM,Migaud Hdoi
10.3109/07420528.2015.1131164subject
Has Abstractpub_date
2016-01-01 00:00:00pages
530-42issue
5eissn
0742-0528issn
1525-6073journal_volume
33pub_type
杂志文章abstract::The organizing committee of the 2016 Rio Olympic Games recently announced that some of the preliminary and final competitions will be held at night. The present article discusses the potential harmful effects of these late-night competitions on sleep, circadian rhythms and athletic performance during the Olympic Games...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2016.1150290
更新日期:2016-01-01 00:00:00
abstract::Seasonal variations have been described in humans in several variables such as sleep, mood, appetite, food preferences, or body weight. We hypothesized that these variations could also influence the decrease in body weight rate in patients submitted to body weight loss interventions. Thus, here we tested the variation...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1580716
更新日期:2019-05-01 00:00:00
abstract::The 10 min psychomotor vigilance task (PVT) is commonly used in laboratory studies to assess the impact of sleep loss, sustained wakefulness, and/or time of day on neurobehavioral performance. In field settings, though, it may be impractical for participants to perform a test of this length. The aim of this study was ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520601067931
更新日期:2006-01-01 00:00:00
abstract::Eight diurnally active (06:00-23:00 h) subjects were adapted for 2 days to the room conditions where the experiments were performed. Blood sampling for adenosine metabolites and metabolizing enzymes was done hourly during the activity span and every 30 min during sleep. The results showed that adenosine and its catabo...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529609012650
更新日期:1996-08-01 00:00:00
abstract::Various processes associated with mammalian reproduction exhibit circadian rhythms, yet no information is available concerning the presence of rhythmicity in meiosis-the crucial process of the production of sex cells. Following meiosis in cells derived from male mice exposed in vivo to daily light-dark cycles (LD), we...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529808998665
更新日期:1998-01-01 00:00:00
abstract::Fourteen healthy subjects have been studied in an isolation unit while living on a 30h "day" (20h awake, 10h asleep) for 14 (solar) days but while aware of real time. Waking activities were sedentary and included reading, watching television, and so forth. Throughout, regular recordings of rectal temperature were made...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529609020906
更新日期:1996-10-01 00:00:00
abstract::In previous experiments, we found that rats raised in constant light (LL) manifested a more robust circadian rhythm of motor activity in LL and showed longer phase shifts after a light pulse in constant darkness (DD) than chose raised under constant darkness. In addition, we observed that the effects produced by const...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100106081
更新日期:2001-07-01 00:00:00
abstract::In amphibians, voltage-gated sodium (Nav) channels in cone ON bipolar cells (ON-CBC) amplify cone signals in the dark and in mesopic background light. However, during light adaptation, dopamine, acting through D1 receptors (D1R), suppresses Nav channels and therefore act as a gain control mechanism. Curiously in roden...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.951054
更新日期:2015-02-01 00:00:00
abstract::The regulation of genetic expression is tightly controlled and well balanced in the organism by different epigenetic mechanisms such as DNA methylation and histone modifications. DNA methylation occurring after embryogenesis is seen mainly as an irreversible event. Even small changes in genomic DNA methylation might b...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701290565
更新日期:2007-01-01 00:00:00
abstract::The aims of this study were to examine the genetic and environmental influences on diurnal preference and sleep quality, the association between these phenotypes, the genetic and environmental influences on this association, and the magnitude of overlap between these influences. Using a twin design, data on diurnal pr...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420521003663801
更新日期:2010-01-01 00:00:00
abstract::Shiftwork, particularly that including night work, causes disruption of biological rhythms and perturbation of the social and family life that can negatively affect performance efficiency, health, and social relations. Adverse effects can manifest themselves in the short term as sleep disturbances, shiftlag syndrome, ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529709001147
更新日期:1997-03-01 00:00:00
abstract::The course of swelling after maxillo-facial surgery was investigated by measuring the distance from the tragus to the pogonium. The post-surgical swelling does not diminish continuously, but decreases in a circaseptan periodic mode. The reactive periodicity is preferentially induced not by the injury, but by the surgi...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528409059133
更新日期:1984-01-01 00:00:00
abstract::In birds, circadian control of tissue level communication is not well understood. The present study investigated this, by monitoring daily oscillation of genes coding for peptides (neuropeptide Y, NPY; vasoactive intestinal peptide, VIP; somatostatis, SST) and intermediary enzymes of amine and amino acid neurotransmit...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2016.1139587
更新日期:2016-01-01 00:00:00
abstract::Police officers are required to work irregular hours, which induces stress, fatigue, and sleep disruption, and they have higher rates of chronic disease and mortality. Cortisol is a well-known "stress hormone" produced via activation of the hypothalamic-pituitary-adrenal axis. An abnormal secretion pattern has been as...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.573112
更新日期:2011-05-01 00:00:00
abstract::Chronotypes have been associated with psychopathology. The eveningness chronotype has been consistently linked with depressed states or depressive disorder, but the underlying mechanism remains unclear. Prior studies have shown associations between chronotype and personality traits that are linked to depression (e.g. ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1345932
更新日期:2017-01-01 00:00:00
abstract::The evening chronotype is strongly associated with greater alcohol use, though mechanisms underlying this association are not well understood. The current study evaluated emotion regulation as a potential mechanism linking evening chronotype and alcohol use. Participants were 81 undergraduate students. Chronotype was ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1800028
更新日期:2020-12-01 00:00:00
abstract::Bone sarcomatous cells derived from human malignant tumors were cultured. The mitotic index was recorded for 39 hr. When the cultured cells originated from patients with cancer disease before any chemotherapy, ultradian mitotic rhythms of a 6-9-hr period were detected, but in many cases only after a sensitive statisti...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528909064628
更新日期:1989-01-01 00:00:00
abstract::Loratadine is a second-generation histamine H(1)-receptor antagonist used in the treatment of allergic diseases. The aim of the study was to assess whether lethal toxicity and motor incoordination (neurotoxicity) of loratadine is circadian rhythm-dependent. A total of 210 male Swiss mice, aged 10 wk, were synchronized...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/CBI-200062369
更新日期:2005-01-01 00:00:00
abstract::Diurnal and seasonal rhythms of cortisol, testosterone, and DHEA were examined, as little is known about the relationship between these rhythmicities and pubertal development. Salivary samples were obtained from 60 boys and 60 girls at approximately 07:45, 08:00, 08:30, 12:00, 16:50, and 21:00 h. The participants' age...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701649471
更新日期:2007-01-01 00:00:00
abstract::Shift workers are known to have an increased risk of developing cardiovascular disease (CVD) compared with day workers. An important factor contributing to this increased risk could be the increased incidence of postprandial metabolic risk factors for CVD among shift workers, as a consequence of the maladaptation of e...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1081/cbi-200037171
更新日期:2004-01-01 00:00:00
abstract::Light is an important environmental stimulus for the entrainment of the circadian clock and for increasing alertness. The intrinsically photosensitive ganglion cells in the retina play an important role in transferring this light information to the circadian system and they are elicited in particular by short-waveleng...
journal_title:Chronobiology international
pub_type: 杂志文章,随机对照试验
doi:10.3109/07420528.2014.893242
更新日期:2014-06-01 00:00:00
abstract::Influences of starvation, re-feeding and time of food supply on daily rhythm features of melatonin (5-methoxy-N-acetyltryptamine) and its key regulator AANAT (arylalkylamine N-acetyltransferase) protein in the gut tissues were separately evaluated in carp Catla catla. The first experiment was aimed at demonstration of...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1087020
更新日期:2015-01-01 00:00:00
abstract::The pharmacokinetics of naproxen was studied in 12 healthy male volunteers after a single oral dose of 500 mg at 10:00 and 22:00 h. Ingestion of drug at 22:00 h delayed the occurrence of peak serum levels (p < 0.0212). None of the other pharmacokinetic parameters exhibited any significant diurnal variations. ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529309059703
更新日期:1993-04-01 00:00:00
abstract::In this study, we aimed to show how age affects hibernation in the Syrian hamster. Experimentally, we used 30 male animals differing in age. The old animals were 20 months of age and the adults were 8 months of age at the end of the test. The young animals were 3 weeks old at the start of testing and 5 months old at t...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100101069
更新日期:2000-09-01 00:00:00
abstract::Social anxiety has recently been linked to morningness-eveningness; however, the psychological mechanisms underlying this relationship are not well known. As such, the purpose of the current study is to propose a model by which morningness-eveningness is related to social anxiety symptoms through punishment sensitivit...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1529679
更新日期:2019-02-01 00:00:00
abstract::The first aim of the study was to assess clock-time patterning of work-related injuries (WRIs) of firemen (FM) of Saône et Loire-71 (France) during the 4-yr span of 1 January 2004 to 31 December 2007. FM of this service are legally required to log every WRI and seek its evaluation by the medical service, whether the W...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.603170
更新日期:2011-10-01 00:00:00
abstract::A physiological dose of orally administered melatonin shifts circadian rhythms in humans according to a phase-response curve (PRC) that is nearly opposite in phase with the PRCs for light exposure: melatonin delays circadian rhythms when administered in the morning and advances them when administered in the afternoon ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529209064550
更新日期:1992-10-01 00:00:00
abstract::In order to optimize chronotherapeutic schedules (designs), we examined the interindividual differences in chronopharmacologic effects of drugs with consideration of the following three factors: (a) inherited factors of direct relevance to chronopharmacology (genetic variability, gender-related differences) as well as...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529309059721
更新日期:1993-12-01 00:00:00
abstract::The validity of a commercially available wearable device for measuring total sleep time was examined in a sample of well-trained young athletes during night-time sleep periods and daytime naps. Participants wore a FitBit HR Charge on their non-dominant wrist and had electrodes attached to their face and scalp to enabl...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1466800
更新日期:2018-06-01 00:00:00
abstract::In mammals, non-visual responses to light involve intrinsically photosensitive melanopsin-expressing retinal ganglion cells (ipRGCs) that receive synaptic inputs from rod and cone photoreceptors. Several studies have shown that cones also play a role in light entrainment, photic responses of the suprachiasmatic nucleu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420521003695704
更新日期:2010-06-01 00:00:00