Abstract:
:Bone sarcomatous cells derived from human malignant tumors were cultured. The mitotic index was recorded for 39 hr. When the cultured cells originated from patients with cancer disease before any chemotherapy, ultradian mitotic rhythms of a 6-9-hr period were detected, but in many cases only after a sensitive statistical analysis was performed. When the cultured cells originated from cancer patients undergoing chemotherapy, the mitotic index was decreased, and the amplitudes of the 6-9-hr component oscillations of the mitotic index were highly significantly increased. Damping and fading out of an ultradian mitotic rhythmicity was a bad prognostic portent in bone cancer. With reference to chemotherapy, the restored and amplified ultradian rhythmicity disclosed an appreciable antitumor effect and better survival prospects for the patient.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Petrovic A,Oudet C,Stutzmann Jdoi
10.3109/07420528909064628subject
Has Abstractpub_date
1989-01-01 00:00:00pages
173-83issue
2eissn
0742-0528issn
1525-6073journal_volume
6pub_type
杂志文章abstract::Sleep and fatigue-associated symptoms are prominent during chemotherapy. The purpose of this pilot study was to examine bright light effects on sleep disruption, fatigue, daytime sleepiness, depression, and quality of life (QOL) in women with stage I-III breast cancer undergoing chemotherapy. In this 2-group randomize...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2021.1871914
更新日期:2021-01-21 00:00:00
abstract::Animal and human studies demonstrate anatomical and functional links between the vestibular nuclei and the circadian timing system. This promotes the hypothesis of a circadian rhythm of vestibular function. The objective of this study was to evaluate the vestibular function through the vestibulo-ocular reflex using a ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1835941
更新日期:2021-01-01 00:00:00
abstract::Circadian changes in activities and electrophoretic pattern of the intestinal brushborder enzymes alkaline phosphatase (EC 3.1.3.1), isomaltase (EC 3.2.1.10) and sucrase (EC 3.2.1.26) of normal rats and of rats with a lesion of the dorsomedial hypothalamus (DMH-rats) were studied. In contrast to the rhythm found in no...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528509055548
更新日期:1985-01-01 00:00:00
abstract::Eight diurnally active (06:00-23:00 h) subjects were adapted for 2 days to the room conditions where the experiments were performed. Blood sampling for adenosine metabolites and metabolizing enzymes was done hourly during the activity span and every 30 min during sleep. The results showed that adenosine and its catabo...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529609012650
更新日期:1996-08-01 00:00:00
abstract::The rods in the retina are responsible for night vision, whereas the cone system enables day vision. We studied whether rod function in humans exhibits an endogenous circadian rhythm and if changes occur in conditions of prolonged darkness. Seven healthy subjects (mean age+/-SD: 25.6+/-12.3 yr) completed a 4.5-day pro...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520802689814
更新日期:2009-01-01 00:00:00
abstract::One proposed hypothesis regarding the etiology of chronic fatigue syndrome (CFS) is that there is a subgroup of patients in which symptom onset is precipitated by a viral infection. If this is indeed true, then one would anticipate a greater incidence of the emergence of CFS symptoms during months when viral infection...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100103194
更新日期:2001-03-01 00:00:00
abstract::Night work has emerged as a risk factor for many chronic diseases, including obesity, diabetes, and cardiovascular disease. While night work is linked to a number of cardiometabolic indices, few studies have explored how different parameters, such as cumulative night work and intensity of night work, may influence car...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1570247
更新日期:2019-05-01 00:00:00
abstract::In the free-running circadian locomotor activity rhythm of a 7-year-old male owl monkey (Aotus lemurinus griseimembra) kept under constant light and climatic conditions (LL 0.2 lux, 25 degrees C +/- 1 degrees C, 60 +/- 5% relative humidity [RH]), a second rhythm component developed that showed strong relative coordina...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100101039
更新日期:2000-03-01 00:00:00
abstract::Exposure to artificial light at night (ALAN) has become increasing common, especially in developed countries. We investigated the effect of dALAN exposure during sleep in healthy young male subjects. A total of 30 healthy young male volunteers from 21 to 29 years old were recruited for the study. They were randomly di...
journal_title:Chronobiology international
pub_type: 杂志文章,随机对照试验
doi:10.3109/07420528.2015.1108980
更新日期:2016-01-01 00:00:00
abstract::The evening chronotype is strongly associated with greater alcohol use, though mechanisms underlying this association are not well understood. The current study evaluated emotion regulation as a potential mechanism linking evening chronotype and alcohol use. Participants were 81 undergraduate students. Chronotype was ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1800028
更新日期:2020-12-01 00:00:00
abstract::Multiple components of the circadian central clock are phosphoproteins, and it has become increasingly clear that posttranslational modification is an important regulator of circadian rhythm in diverse organisms, from dinoflagellates to humans. Genetic studies in Drosophila have identified double-time (dbt), a serine/...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-100103963
更新日期:2001-05-01 00:00:00
abstract::This study investigates if the serotoninergic system plays a role in chronotoxic effects of the anticancer agent oxaliplatin (l-OHP). Four groups of female rats (120 in total) synchronized with light-dark (12 h:12 h) were treated with: (i) saline, (ii) para-chlorophenylalanine (pCPA, an inhibitor of serotonin biosynth...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120015957
更新日期:2002-11-01 00:00:00
abstract::In Channa punctatus, a significant daily variation in hypothalamic 5-HT level and monoamine oxidase (MAO) activity was noticed in preparatory phase (February), but not in prespawning (May) or postspawning (November) phases. Hypothalamic dopamine (DA) and noradrenaline (NA), on the other hand, showed marked daily varia...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528809067776
更新日期:1988-01-01 00:00:00
abstract::Dysregulation of the system of nitric oxide (NO)-cyclic 3',5'-guanosine monophosphate (cGMP) might be involved in the development of hypertension in transgenic hypertensive TGR(mREN2)27 (TGR) rats. The present study was performed to determine possible differences in the day-night pattern and the urinary excretion rate...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529909116860
更新日期:1999-05-01 00:00:00
abstract::The circadian timing system adapts most of the mammalian physiology and behaviour to the 24 h light/dark cycle. This temporal coordination relies on endogenous circadian clocks present in virtually all tissues and organs and implicated in the regulation of key cellular processes including metabolism, transport and sec...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1046601
更新日期:2015-01-01 00:00:00
abstract::Postoperative delirium, a common perioperative complication, is frequently observed in elderly surgical patients. Few studies have investigated the life rhythm of preoperative patients, and whether or not the preoperative life rhythm is associated with the development of postoperative delirium. The purpose of this stu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1764012
更新日期:2020-07-01 00:00:00
abstract::Daily variation in the absorption, metabolism and excretion of toxic substances will ultimately determine the actual concentration to which the cells and tissues are exposed. In aquaculture, Atlantic salmon (Salmo salar) can be frequently exposed to hydrogen peroxide (H2O2) to treat topical skin and gill infections, p...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1131164
更新日期:2016-01-01 00:00:00
abstract::This study investigated (i) blood pressure (BP), heart rate (HR), and their relation to urinary NOx and eNOS protein expression in male and female spontaneously hypertensive rats (SHR), as well as (ii) gender-dependent cardiovascular effects of nebivolol (NEB) in comparison to metoprolol (MET) in SHR. BP and HR were m...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520600827129
更新日期:2006-01-01 00:00:00
abstract::In the contemporary era, when life habits are largely determined by social needs and individual preferences, sleep is nevertheless affected by seasonal environmental changes. Japan has large seasonal and geographical alterations of photoperiod and climate. Japan does not adopt the daylight saving time (DST) system, ma...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1443118
更新日期:2018-07-01 00:00:00
abstract::Two different medications, one assumed to be a tranquilizer and the other an antifatigue agent, were tested. Both were found to be ineffective and thus were viewed as placebos and named P1 and P2. The effect of P1 and P2 on the circadian rhythms of a set of variables (e.g., sleep/wake, oral temperature and grip streng...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07420529409057230
更新日期:1994-02-01 00:00:00
abstract::Behavior, physiological functions and cognitive performance change over the time of the day. These daily rhythms are either externally driven by rhythmic environmental cues such as the light/dark cycle (masking) or controlled by an internal circadian clock, the suprachiasmatic nucleus (SCN), which can be entrained to ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.956218
更新日期:2015-02-01 00:00:00
abstract::High fat diet (HFD) consumption alters the synchronized circadian timing system resulting in harmful loss, gain or shift of transcriptional oscillations. The aryl hydrocarbon receptor (AhR) shares structural homology to clock genes, containing both PAS domains and basic helix-loop helix structural motifs, allowing for...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2016.1256298
更新日期:2017-01-01 00:00:00
abstract::This study aims to investigate independent associations of habitual sleep durations and sleep timings on weekdays and weekends with depressive symptoms in adolescents who have classes in the morning. We studied grade 7-9 students (942 males and 940 females, aged 12-15 years), who had classes in the morning, at public ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1746796
更新日期:2020-06-01 00:00:00
abstract::This retrospective study tested the hypothesis that disease control and treatment-related toxicity in patients undergoing high-dose radiotherapy (HDRT) for prostate cancer varies in a circadian manner. Patients with localized prostate adenocarcinoma receiving HDRT (median 78 Gy) to the prostate and involved seminal ve...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1130049
更新日期:2016-01-01 00:00:00
abstract::The objective of this study was to test the hypothesis that there is seasonal variation in the incidence of Stanford type A aortic dissection (SA-AoD) among patients admitted to our cardiovascular surgical service. A sinusoidal logistic regression model was used to analyze event data for 6081 calendar days. A cyclic p...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.933842
更新日期:2014-11-01 00:00:00
abstract::Few studies have focused on the influence of circadian typology on drug use, and none has considered the use of illegal drugs and hazardous alcohol consumption. This study analyzes the influence of circadian typology on several types of drug consumption (habitual or sporadic), hangover symptoms (past 12 mos), and, mor...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.553018
更新日期:2011-04-01 00:00:00
abstract::Boundaries between work and private life are diminishing, but little is known on how this influences worker health. Therefore, we examined the association between work-related contacts outside of regular working hours by e-mail or phone and self-reported health in a representative sample of European employees (n = 23 ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.800089
更新日期:2013-11-01 00:00:00
abstract::The suprachiasmatic nucleus (SCN) of the hypothalamus is considered the master circadian oscillator in mammals. However, extra-SCN structures in the brain also display daily rhythms. Recently, we have demonstrated that the choroid plexus (CP) expresses core clock genes that are subjected to circadian regulation in a s...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1400978
更新日期:2018-02-01 00:00:00
abstract::Semilunar and lunar rhythms are often controlled endogenously, but the mechanisms of their respective free-run periods, when external factors are absent, are mostly unclear. In this investigation, the authors studied the mechanism controlling the period of the circasemilunar emergence rhythm of a marine midge, Pontomy...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.728548
更新日期:2012-12-01 00:00:00
abstract::The authors estimated the benchmark durations (BMDs) and their 95% lower confidence limit (BMDL) for the reference duration of shiftwork for weight gain. A 14-yr prospective cohort study was conducted in male workers at a Japanese steel company (n = 7254) who had received annual health check-ups between 1991 and 2005....
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2010.516045
更新日期:2010-10-01 00:00:00