Abstract:
:This retrospective study tested the hypothesis that disease control and treatment-related toxicity in patients undergoing high-dose radiotherapy (HDRT) for prostate cancer varies in a circadian manner. Patients with localized prostate adenocarcinoma receiving HDRT (median 78 Gy) to the prostate and involved seminal vesicle(s) without elective pelvic irradiation were divided into a daytime treatment (before 5 PM) group (n = 267) and evening treatment (after 5 PM) group (n = 142). Biochemical failure (Phoenix definition), acute and late gastrointestinal (GI) and genitourinary toxicities (Common Terminology Criteria for Adverse Events version 4), biochemical failure-free survival (BFFS) and freedom from late toxicity were assessed. Analyses were performed by binary logistic regression and Cox proportional hazard regression. The median follow-up was 68 months, and 75% of patients were ≥70 years old. Evening HDRT was significantly associated with worse freedom from ≥grade 2 late GI complications (hazard ratio = 2.96; p < 0.001). The detrimental effect of evening HDRT was significant in patients older than 70 years old (p < 0.001) but not in younger patients (p = 0.63). In a subgroup of propensity score-matched cohort with T2b-T3 disease (n = 154), the 5-year BFFS was worse in the evening group than the daytime group (72% vs. 85%, hazard ratio = 1.95, p = 0.05). Our study indicates that evening HDRT may lead to more GI complications, especially in older patients, and worse BFFS in patients with T2b-T3 disease.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Hsu FM,Hou WH,Huang CY,Wang CC,Tsai CL,Tsai YC,Yu HJ,Pu YS,Cheng JCdoi
10.3109/07420528.2015.1130049subject
Has Abstractpub_date
2016-01-01 00:00:00pages
210-9issue
2eissn
0742-0528issn
1525-6073journal_volume
33pub_type
杂志文章abstract::The course of swelling after maxillo-facial surgery was investigated by measuring the distance from the tragus to the pogonium. The post-surgical swelling does not diminish continuously, but decreases in a circaseptan periodic mode. The reactive periodicity is preferentially induced not by the injury, but by the surgi...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528409059133
更新日期:1984-01-01 00:00:00
abstract::In the laboratory rat, a number of physiological parameters display seasonal changes even under constant conditions of temperature, lighting, and food availability. Since there is evidence that prolactin (PRL) is, among the endocrine signals, a major mediator of seasonal adaptations, the authors aimed to examine wheth...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.705936
更新日期:2012-10-01 00:00:00
abstract::Light-at-night (LAN) is a worldwide problem co-distributed with breast cancer prevalence. We hypothesized that exposure to LAN is coincided with a decreased melatonin (MLT) secretion level, followed by epigenetic modifications and resulted in higher breast cancer tumors growth-rate. Accordingly, we studied the effect ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.842925
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abstract::Therapy with oral anticoagulants (OACs) is a risk factor for cerebral hemorrhage (CH). Although different studies have been undertaken to investigate the timing of the onset of major cardiovascular events, no data exist on temporal patterns of the onset of CH in subjects treated with OACs. The aim of this study is to ...
journal_title:Chronobiology international
pub_type: 杂志文章,多中心研究
doi:10.3109/07420528.2015.1133636
更新日期:2016-01-01 00:00:00
abstract::In situ growth of Sphagnum riparium Ångstr. shoots were monitored during the 2015 and 2016 growing seasons in Karelia, Russia. It was established that shoot growth rates fluctuated with a period of around 30 days, that is, showed a circatrigintan rhythm. Such rhythms from mosses have not been previously reported. Corr...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1329208
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abstract::In 24h studies of bone marrow (BM), circadian stage-dependent variations were demonstrated in the proliferative activity of BM cells from subsets of 35 healthy diurnally active men. On an average, the percentage of total BM cells in deoxyribonucleic acid (DNA) synthesis phase was 188% greater at midday than at midnigh...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-120002594
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abstract::Circadian rhythms in mammals are adjusted daily to the environmental day/night cycle by photic input via the retinohypothalamic tract (RHT). Retinal ganglion cells (RGCs) of the RHT constitute a separate light-detecting system in the mammalian retina used for irradiance detection and for transmission to the circadian ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520500464544
更新日期:2006-01-01 00:00:00
abstract::The present study was designed to investigate the effect of Ramadan fasting on feelings, dietary intake, rating of perceived exertion (RPE) and repeated high-intensity short-term maximal performance. Thirteen physically active men (age: 21.2 ± 2.9 years, height: 175.6 ± 5.6 cm, body-mass: 72.4 ± 8.6 kg) performed a 5-...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1513943
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abstract::Humans may be subject to seasonal variations, as evidenced by the existence of seasonal affective disorder (SAD) and midwinter insomnia. However, some recent studies have shown that the seasonal variation in the phase of the circadian rhythm is relatively weak in healthy humans. In the present study, evidence is found...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529808993198
更新日期:1998-11-01 00:00:00
abstract::Shift workers are known to have an increased risk of developing cardiovascular disease (CVD) compared with day workers. An important factor contributing to this increased risk could be the increased incidence of postprandial metabolic risk factors for CVD among shift workers, as a consequence of the maladaptation of e...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-01-01 00:00:00
abstract::There is strong association between chronic kidney disease (CKD) and increased prevalence of hypertension, risk of end-organ damage, and cardiovascular disease (CVD). Non-dipping, as determined by ambulatory blood pressure (BP) monitoring (ABPM), is frequent in CKD and has also been consistently associated with increa...
journal_title:Chronobiology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/07420528.2012.703083
更新日期:2013-03-01 00:00:00
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journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520902772221
更新日期:2009-02-01 00:00:00
abstract::The aim of this study was to examine the impact of brief, unscheduled naps during work periods on alertness and vigilance in coastal pilots along the Great Barrier Reef. On certain routes, the duration of the work period can extend well beyond 24 h. Seventeen coastal pilots volunteered for the study, representing almo...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520802106819
更新日期:2008-04-01 00:00:00
abstract::The purpose of this study was to investigate the influence of rest-activity rhythm on the survival of cancer patients. This study collected data related to cancer patients experiencing pain who had been hospitalized for treatment between August 2006 and October 2007. Data included the Karnofsky Performance Status Inde...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.931412
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journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120015957
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abstract::The phase and period responses to short light pulses were studied in the jerboa, a seasonal, hibernating, nocturnal rodent from the Atlas region in Morocco. The jerboa, which is a saltatory species, showed precise activity onsets and offsets under a light-dark (LD) cycle using infrared captors to record locomotor acti...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2010.504315
更新日期:2010-08-01 00:00:00
abstract::Circadian rhythms of plasma insulin, cortisol, and glucose concentrations were examined in scotosensitive (reproductively sensitive to inhibitory effects of short daylengths) and scotorefractory male and female Syrian hamsters (Mesocricetus auratus) maintained on short (LD 10:14) and long (LD 14:10) daylengths. The ba...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528709078520
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abstract::In order to optimize chronotherapeutic schedules (designs), we examined the interindividual differences in chronopharmacologic effects of drugs with consideration of the following three factors: (a) inherited factors of direct relevance to chronopharmacology (genetic variability, gender-related differences) as well as...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529309059721
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abstract::A physiological dose of orally administered melatonin shifts circadian rhythms in humans according to a phase-response curve (PRC) that is nearly opposite in phase with the PRCs for light exposure: melatonin delays circadian rhythms when administered in the morning and advances them when administered in the afternoon ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529209064550
更新日期:1992-10-01 00:00:00
abstract::Due to personal and working necessities, the time for exercise is often short, and scheduled early in the morning or late in the afternoon. Cortisol plays a central role in the physiological and behavioral response to a physical challenge and can be considered as an index of exercise stress. Therefore, the aim of this...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1311336
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abstract::Patients with resistant hypertension (RH) are at greater risk for stroke, renal insufficiency, and cardiovascular disease (CVD) events than are those for whom blood pressure (BP) is responsive to and well controlled by therapeutic interventions. Although all chronotherapy trials have compared the effects on BP regulat...
journal_title:Chronobiology international
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract::Time-dependent variations in the vasodilator effects of beta-adrenergic agonists terbutaline (Ter) and dobutamine (Dob) were studied in isolated rings of rat thoracic aorta in both endothelium-intact and endothelium-denuded preparations. Rats were housed in light from 08:00 to 20:00 and in darkness from 20:00 to 08:00...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529808998680
更新日期:1998-03-01 00:00:00
abstract::Lung cancer is the leading cause of cancer deaths worldwide. Both incidence and mortality of lung cancer are especially high in Hungary. Several investigations suggested recently that month of birth (MOB) is associated with the risks of several nonmalignant disorders as well as some malignant disorders. Only a few stu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.596294
更新日期:2011-08-01 00:00:00
abstract::Hyperphosphatemia is a common complication of chronic kidney disease (CKD) and is associated with cardiovascular disease (CVD), which has contributed to an increase in mortality of CKD patients. The onset of CVD often varies by time-of-day. Acute myocardial infarction or ventricular arrhythmia occurs most frequently d...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1486850
更新日期:2018-09-01 00:00:00
abstract::Correlation between systolic (SBP) and diastolic (DBP) blood pressure (BP) level and target organ damage, cardiovascular disease (CVD) risk, and long-term prognosis is much greater for ambulatory BP monitoring (ABPM) than daytime office measurements. The 2013 ABPM guidelines specified herein are based on ABPM patient ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.750490
更新日期:2013-04-01 00:00:00
abstract::Workers who meet the criteria for shift work disorder (SWD) have elevated levels of risk for various health and behavioral problems. However, the impact of having SWD on shiftworkers engaged in rapid-rotation schedules is unknown. Moreover, the risk factors for the occurrence of SWD remain unclear. To clarify these is...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.762010
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abstract::In 33 patients with heart failure (NYHA II-III), the 24-h blood pressure rhythm was examined before and after the titration period of two ACE inhibitors. Blood pressure was measured by the oscillometric method using the blood pressure monitor 90202 from SpaceLabs, Inc. The measurements were taken from 06:00 to 22:00 h...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::Thermoregulatory processes have long been implicated in the initiation of human sleep. In this paper, we review our own studies conducted over the last decade showing a crucial role for melatonin as a mediator between the thermoregulatory and arousal system in humans. Distal heat loss, via increased skin temperature, ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
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abstract::The season of birth has been suggested to influence the development of some diseases, but its role in lung fibrosis seems to not have been studied previously. The aim of this study was to investigate the relation between the season of birth and fibrotic abnormalities as detected radiologically in high-resolution compu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701420725
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abstract::Twenty-four different laboratory parameters including the phagocytic activity (phagocytic index) of polymorphonuclear leukocytes (PMNs) and various hematologic variables were investigated in 13 young healthy men during Spring 1988 in Munich, Germany. Venous blood of these volunteers was obtained under standardized con...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529209064514
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