Abstract:
:Light-at-night (LAN) is a worldwide problem co-distributed with breast cancer prevalence. We hypothesized that exposure to LAN is coincided with a decreased melatonin (MLT) secretion level, followed by epigenetic modifications and resulted in higher breast cancer tumors growth-rate. Accordingly, we studied the effect of LAN exposure and exogenous MLT on breast cancer tumors growth-rate. 4T1 cells were inoculated into BALB/c short day-acclimated mice, resulting in tumors growth. Growth rates were followed under various light exposures and global DNA methylations were measured. Results demonstrated the positive effect of LAN on tumors growth-rate, reversed by MLT through global DNA methylation.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Schwimmer H,Metzer A,Pilosof Y,Szyf M,Machnes ZM,Fares F,Harel O,Haim Adoi
10.3109/07420528.2013.842925subject
Has Abstractpub_date
2014-02-01 00:00:00pages
144-50issue
1eissn
0742-0528issn
1525-6073journal_volume
31pub_type
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