Abstract:
:Circadian phase dependency in pharmacokinetics and hemodynamic effects on blood pressure and heart rate of different galenic formulations of nifedipine (immediate-release, sustained-release, and i.v. solution) were studied in healthy subjects or in hypertensive patients. Pharmacokinetics of immediate-release but not sustained-release and i.v. nifedipine were dependent on time of day: immediate-release nifedipine had higher Cmax (peak concentration) and shorter tmax (time-to-peak concentration) after morning than evening application, and bioavailability in the evening was reduced by about 40%. Circadian rhythm in estimated hepatic blood flow as determined by indocyanine green kinetics may contribute to these chronokinetics. A circadian time dependency was also found in nifedipine-induced effects on blood pressure and heart rate as monitored by 24-h ambulatory blood pressure measurements. In conclusion, the dose response relationship of oral nifedipine is influenced by the circadian organization of the cardiovascular system as well as by the galenic drug formulation.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Lemmer B,Nold G,Behne S,Kaiser Rdoi
10.3109/07420529109059184subject
Has Abstractpub_date
1991-01-01 00:00:00pages
485-94issue
6eissn
0742-0528issn
1525-6073journal_volume
8pub_type
杂志文章abstract::Dysfunctional regulation of brain dopamine (DA) functions has been found in patients with drug addiction and various neurological disorders that frequently accompany disturbance in sleep behavior. In this study, the roles of the dopaminergic nervous system on the regulation of daily locomotor activity rhythm were inve...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.741169
更新日期:2013-05-01 00:00:00
abstract::Immune cell trafficking is crucial for surveillance and effector functions of the immune system. Circadian rhythms of the hypothalamic-pituitary-adrenal (HPA) axis and of cortisol have been implicated in circadian redistribution of circulating lymphocytes and granulocytes. However, information regarding the diurnal re...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.775654
更新日期:2013-06-01 00:00:00
abstract::In this paper, a peptic ulcer is considered from the perspective that it is representative of a heterogeneous group of multifactorial determined or influenced disorders having a common pathomorphologic expression. This heterogeneity involves pathophysiological attributes, including both functional (including secretory...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1080/07420528709078511
更新日期:1987-01-01 00:00:00
abstract::Shiftwork, particularly that including night work, causes disruption of biological rhythms and perturbation of the social and family life that can negatively affect performance efficiency, health, and social relations. Adverse effects can manifest themselves in the short term as sleep disturbances, shiftlag syndrome, ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529709001147
更新日期:1997-03-01 00:00:00
abstract::Eveningness and sleep disturbances are considered as markers of Bipolar Disorder (BD) and influence mood and emotional or behavioral states. This study investigates the associations between circadian markers and sleep quality on residual depressive symptoms and inhibition/activation dimensions during the euthymic phas...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1685533
更新日期:2020-01-01 00:00:00
abstract::Dysregulation of the system of nitric oxide (NO)-cyclic 3',5'-guanosine monophosphate (cGMP) might be involved in the development of hypertension in transgenic hypertensive TGR(mREN2)27 (TGR) rats. The present study was performed to determine possible differences in the day-night pattern and the urinary excretion rate...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529909116860
更新日期:1999-05-01 00:00:00
abstract::Loratadine is a second-generation histamine H(1)-receptor antagonist used in the treatment of allergic diseases. The aim of the study was to assess whether lethal toxicity and motor incoordination (neurotoxicity) of loratadine is circadian rhythm-dependent. A total of 210 male Swiss mice, aged 10 wk, were synchronized...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/CBI-200062369
更新日期:2005-01-01 00:00:00
abstract::The aim of the study was to evaluate the influence of chronotype (morning-type versus evening-type) living in a fixed sleep-wake schedule different from one's preferred sleep schedules on the time course of neurobehavioral performance during controlled extended wakefulness. The authors studied 9 morning-type and 9 eve...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.590623
更新日期:2011-07-01 00:00:00
abstract::Several substances change the period length of the circadian oscillator in the laminar pulvinus of Phaseolus coccineus L. if offered continuously via the transpiration stream to the isolated leaves in continuous light and constant temperature. The osmotica mannitol and PEG 6000 (polyethylene glycol) lengthen the circa...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528509055537
更新日期:1985-01-01 00:00:00
abstract::Total sleep deprivation (TSD) is known to impair sustained attention. However, previously reported effects of TSD on response inhibition are mixed. We administered a "stop-signal" variation of the psychomotor vigilance test, which included 25% of trials requiring withholding of a response to assess response inhibition...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1811718
更新日期:2020-08-25 00:00:00
abstract::Disruption of circadian rhythms, which frequently occurs during night shift work, may be associated with cancer progression. The effect of chronotype (preference for behaviors such as sleep, work, or exercise to occur at particular times of day, with an associated difference in circadian physiology) and alignment of b...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.842575
更新日期:2014-03-01 00:00:00
abstract::Two different medications, one assumed to be a tranquilizer and the other an antifatigue agent, were tested. Both were found to be ineffective and thus were viewed as placebos and named P1 and P2. The effect of P1 and P2 on the circadian rhythms of a set of variables (e.g., sleep/wake, oral temperature and grip streng...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07420529409057230
更新日期:1994-02-01 00:00:00
abstract::Few studies have focused on the influence of circadian typology on drug use, and none has considered the use of illegal drugs and hazardous alcohol consumption. This study analyzes the influence of circadian typology on several types of drug consumption (habitual or sporadic), hangover symptoms (past 12 mos), and, mor...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.553018
更新日期:2011-04-01 00:00:00
abstract::Stress is associated with significant losses in the swine industry. Seasonal changes have been shown to affect stress resistance in several species of animals. In the present study, we examined the effect of two seasons (fall or winter) on plasma insulin, cortisol, and adrenocorticotrophin hormone (ACTH) levels from f...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529808998689
更新日期:1998-05-01 00:00:00
abstract::Behavior, physiological functions and cognitive performance change over the time of the day. These daily rhythms are either externally driven by rhythmic environmental cues such as the light/dark cycle (masking) or controlled by an internal circadian clock, the suprachiasmatic nucleus (SCN), which can be entrained to ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.956218
更新日期:2015-02-01 00:00:00
abstract::The circadian clock of man and mammals shows a hierarchic organization. The master clock, located in the suprachiasmatic nuclei (SCN), controls peripheral oscillators distributed throughout the body. Rhythm generation depends on molecular clockworks based on transcriptional/translational interaction of clock genes. Nu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.949735
更新日期:2015-02-01 00:00:00
abstract::The evening chronotype is strongly associated with greater alcohol use, though mechanisms underlying this association are not well understood. The current study evaluated emotion regulation as a potential mechanism linking evening chronotype and alcohol use. Participants were 81 undergraduate students. Chronotype was ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1800028
更新日期:2020-12-01 00:00:00
abstract::Serotonergic neurotransmission and the master circadian CLOCK gene are physiological modulators of the circadian system. In addition, both are involved in the physiopathology of metabolic syndrome (MS). The authors sought to examine the potential effect of the gene-gene interaction between the functional 44-bp inserti...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2010.496913
更新日期:2010-07-01 00:00:00
abstract::Postoperative delirium, a common perioperative complication, is frequently observed in elderly surgical patients. Few studies have investigated the life rhythm of preoperative patients, and whether or not the preoperative life rhythm is associated with the development of postoperative delirium. The purpose of this stu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1764012
更新日期:2020-07-01 00:00:00
abstract::A synopsis of the effects of exercise on the circadian system in nocturnal rodents is followed by a review of the few studies investigating the influence of exercise on the human circadian system. It is premature to make specific recommendations about using exercise to promote synchronization in people because of the ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529709001157
更新日期:1997-03-01 00:00:00
abstract::The electronic health record (EHR) contains rich histories of clinical care, but has not traditionally been mined for information related to sleep habits. Here, we performed a retrospective EHR study based on a cohort of 3,652 individuals with self-reported sleep behaviors documented from visits to the sleep clinic. T...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1508152
更新日期:2018-11-01 00:00:00
abstract::Fatigue is an increasingly noted factor in road accidents. The ability to predict and be aware of impairment in terms of driving capability is important for potential legal liability and road safety. However, to date, there have been few studies that have investigated the accuracy of individuals in predicting how safe...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520601083391
更新日期:2006-01-01 00:00:00
abstract::It has long been recognized that older shift workers may have shorter and more disturbed day sleeps between successive night shifts than their younger colleagues. This has given rise to considerable concern over the safety of aging shift workers because of the increasing age of the work force and increases in retireme...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1080/07420520802106694
更新日期:2008-04-01 00:00:00
abstract::It has been previously documented that aspirin induced gastric injury of healthy male volunteers was greater in the morning than in the evening. We have also reported that fasting gastric acid secretion rates and gastric retention times for solids were lower in the morning hours of the circadian cycle. We hypothesized...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528809067784
更新日期:1988-01-01 00:00:00
abstract::The aim of this study was to examine the sleep strategies used in breaks between consecutive shifts. For two weeks, 253 shiftworkers collected data regarding the timing of all shifts and sleeps. The final dataset included 395 between-shift breaks that had a standard duration (i.e. ~16 h). If a break included an entire...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2016.1167716
更新日期:2016-01-01 00:00:00
abstract::The authors estimated the benchmark durations (BMDs) and their 95% lower confidence limit (BMDL) for the reference duration of shiftwork for weight gain. A 14-yr prospective cohort study was conducted in male workers at a Japanese steel company (n = 7254) who had received annual health check-ups between 1991 and 2005....
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2010.516045
更新日期:2010-10-01 00:00:00
abstract::The organizing committee of the 2016 Rio Olympic Games recently announced that some of the preliminary and final competitions will be held at night. The present article discusses the potential harmful effects of these late-night competitions on sleep, circadian rhythms and athletic performance during the Olympic Games...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2016.1150290
更新日期:2016-01-01 00:00:00
abstract::Patients with resistant hypertension (RH) are at greater risk for stroke, renal insufficiency, and cardiovascular disease (CVD) events than are those for whom blood pressure (BP) is responsive to and well controlled by therapeutic interventions. Although all chronotherapy trials have compared the effects on BP regulat...
journal_title:Chronobiology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/07420528.2012.701460
更新日期:2013-03-01 00:00:00
abstract::Night shiftworkers often complain of disturbed sleep during the day. This could be partly caused by morning sunlight exposure during the commute home, which tends to maintain the circadian clock on a daytime rhythm. The circadian clock is most sensitive to the blue portion of the visible spectrum, so our aim was to de...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520903044398
更新日期:2009-07-01 00:00:00
abstract::Multiple components of the circadian central clock are phosphoproteins, and it has become increasingly clear that posttranslational modification is an important regulator of circadian rhythm in diverse organisms, from dinoflagellates to humans. Genetic studies in Drosophila have identified double-time (dbt), a serine/...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-100103963
更新日期:2001-05-01 00:00:00