Dopamine D2 receptor as a cellular component controlling nocturnal hyperactivities in Drosophila melanogaster.

Abstract:

:Dysfunctional regulation of brain dopamine (DA) functions has been found in patients with drug addiction and various neurological disorders that frequently accompany disturbance in sleep behavior. In this study, the roles of the dopaminergic nervous system on the regulation of daily locomotor activity rhythm were investigated in Drosophila melanogaster. Reduced synaptic DA release by expressing tetanus toxin gradually attenuated peak activity levels by altering activity patterns, particularly under constant darkness. Besides, flies with a mutant dopamine transporter fumin (fmn), in which the synaptic DA levels were elevated, displayed increased activities in both daytime and nighttime, but did more so at nighttime, suggesting that DA function is involved in regulation of fruit fly's nocturnal locomotor activities. Furthermore, flies treated with bromocriptine, an agonist of Drosophila dopamine D2 receptor (dD2R), exhibited nocturnal locomotor hyperactivity in a dose-dependent manner and this effect was inhibited in dD2R knockdown flies. When mutant flies null for period (per), timeless (tim), dClock (dClk), or cycle (cyc) were treated with bromocriptine, only cycle-null flies (cyc(01)) did not show induced nocturnal hyperactivities, suggesting that cyc might play a role in bromocriptine-induced nocturnal hyperactivities. Elevation of experimental temperature also increased nocturnal activities at the expense of daytime activities. The heat-induced increase in nocturnal activities gradually returned to basal levels at continuously elevated temperature. Inhibition of DA synthesis did not suppress heat-induced early development of nocturnal hyperactivity but prevented gradual decrement of initially elevated nocturnal activities, suggesting that DA impinges on certain adaptive roles in response to changes in environmental temperature. These results overall suggest that controlling dopaminergic transmission is important for daily locomotor behavior and bromocriptine-induced nocturnal hyperactivity which is mediated through dD2R receptor and CYC functions. In parallel to these results, excessive activation of dopaminergic neurotransmission, the primary cause of schizophrenia, is associated with abnormally elevated nocturnal locomotor activities through D2-type receptor in Drosophila. The results suggest that fruit flies are an excellent model system to provide some answers to previously unexplainable observations regarding the compromised dopaminergic nervous system and the related therapeutic agents.

journal_name

Chronobiol Int

authors

Lee G,Kikuno K,Bahn JH,Kim KM,Park JH

doi

10.3109/07420528.2012.741169

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

443-59

issue

4

eissn

0742-0528

issn

1525-6073

journal_volume

30

pub_type

杂志文章
  • In vitro susceptibility rhythms. II. Biological-time-dependent differences in effect of beta 1- and beta 2-adrenergic agonists of rat aorta and influence of endothelium.

    abstract::Time-dependent variations in the vasodilator effects of beta-adrenergic agonists terbutaline (Ter) and dobutamine (Dob) were studied in isolated rings of rat thoracic aorta in both endothelium-intact and endothelium-denuded preparations. Rats were housed in light from 08:00 to 20:00 and in darkness from 20:00 to 08:00...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420529808998680

    authors: Güney HZ,Hodoğlugil U,Uluoğlu C,Görgün CZ,Ercan ZS,Abacioğlu N,Zengil H

    更新日期:1998-03-01 00:00:00

  • Irradiation with X-rays phase-advances the molecular clockwork in liver, adrenal gland and pancreas.

    abstract::The circadian clock of man and mammals shows a hierarchic organization. The master clock, located in the suprachiasmatic nuclei (SCN), controls peripheral oscillators distributed throughout the body. Rhythm generation depends on molecular clockworks based on transcriptional/translational interaction of clock genes. Nu...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2014.949735

    authors: Müller MH,Rödel F,Rüb U,Korf HW

    更新日期:2015-02-01 00:00:00

  • Annual changes in the copulatory behavior of male rats maintained under constant laboratory conditions.

    abstract::The objective of the present study was to evaluate the sexual behavior of male rats kept under constant laboratory conditions for one entire year. A total of 213 sexually-inexperienced, male Wistar rats were maintained in controlled environmental conditions from birth. Depending the month in which they reached the age...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2020.1715997

    authors: Ramírez-Rentería ML,Hernández-Arteaga E,Hernández González M,Cruz-Aguilar MA,Ortega-Hernández TMF,Sotelo-Tapia C,Guevara MA

    更新日期:2020-02-01 00:00:00

  • Age affects hibernation in Syrian hamsters (Mesocricetus auratus).

    abstract::In this study, we aimed to show how age affects hibernation in the Syrian hamster. Experimentally, we used 30 male animals differing in age. The old animals were 20 months of age and the adults were 8 months of age at the end of the test. The young animals were 3 weeks old at the start of testing and 5 months old at t...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1081/cbi-100101069

    authors: Terada A,Ibuka N

    更新日期:2000-09-01 00:00:00

  • Chronopharmacokinetics and cardiovascular effects of nifedipine.

    abstract::Circadian phase dependency in pharmacokinetics and hemodynamic effects on blood pressure and heart rate of different galenic formulations of nifedipine (immediate-release, sustained-release, and i.v. solution) were studied in healthy subjects or in hypertensive patients. Pharmacokinetics of immediate-release but not s...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420529109059184

    authors: Lemmer B,Nold G,Behne S,Kaiser R

    更新日期:1991-01-01 00:00:00

  • Some perturbations that disturb the circadian melatonin rhythm.

    abstract::The circadian melatonin rhythm is highly reproducible and generally not easily altered. The few perturbations that are capable of significantly changing either the amplitude or the pattern of the 24-h melatonin rhythm are summarized herein. Aging alters cyclic melatonin production by decreasing the amplitude of the no...

    journal_title:Chronobiology international

    pub_type: 杂志文章,评审

    doi:10.3109/07420529209064541

    authors: Reiter RJ,Richardson BA

    更新日期:1992-08-01 00:00:00

  • Twelve-hour night shifts of healthcare workers: a risk to the patients?

    abstract::We assessed the impact of 12h fixed night shift (19:00-07:00h) work, followed by 36h of off-time, on the sleep-wake cycle, sleep duration, self-perceived sleep quality, and work-time alertness on a group composed of 5 registered and 15 practical nurses. Wrist actigraphy (Ambulatory Monitoring, Inc.), with data analysi...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1081/cbi-120019341

    authors: Borges FN,Fischer FM

    更新日期:2003-03-01 00:00:00

  • Evening chronotype, alcohol use disorder severity, and emotion regulation in college students.

    abstract::The evening chronotype is strongly associated with greater alcohol use, though mechanisms underlying this association are not well understood. The current study evaluated emotion regulation as a potential mechanism linking evening chronotype and alcohol use. Participants were 81 undergraduate students. Chronotype was ...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2020.1800028

    authors: Taylor BJ,Bowman MA,Brindle A,Hasler BP,Roecklein KA,Krafty RT,Matthews KA,Hall MH

    更新日期:2020-12-01 00:00:00

  • Association of overtime work and hypertension in a Japanese working population: a cross-sectional study.

    abstract::Long working hours have been associated with an increased risk of cardiovascular disease, but its relationship with hypertension remains unclear. The objective of this study is to examine the relationship between overtime and presence of hypertension using data from a large-scale multi-company study in Japan. Particip...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2014.957298

    authors: Imai T,Kuwahara K,Nishihara A,Nakagawa T,Yamamoto S,Honda T,Miyamoto T,Kochi T,Eguchi M,Uehara A,Kuroda R,Omoto D,Nagata T,Pham NM,Kurotani K,Nanri A,Akter S,Kabe I,Mizoue T,Sone T,Dohi S,Japan Epidemiology Coll

    更新日期:2014-12-01 00:00:00

  • Temporal variations of adenosine metabolism in human blood.

    abstract::Eight diurnally active (06:00-23:00 h) subjects were adapted for 2 days to the room conditions where the experiments were performed. Blood sampling for adenosine metabolites and metabolizing enzymes was done hourly during the activity span and every 30 min during sleep. The results showed that adenosine and its catabo...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420529609012650

    authors: Chagoya de Sánchez V,Hernández-Muñoz R,Suárez J,Vidrio S,Yáñez L,Aguilar-Roblero R,Oksenberg A,Vega-González A,Villalobos L,Rosenthal L,Fernández-Cancino F,Drucker-Colín R,Díaz-Muñoz M

    更新日期:1996-08-01 00:00:00

  • Diurnal variations in cycling kinematics.

    abstract::Physiological and biomechanical constraints as well as their fluctuations throughout the day must be considered when studying determinant factors in the preferred pedaling rate of elite cyclists. The aim of this study was to monitor the diurnal variation of spontaneous pedaling rate and movement kinematics over the cr...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1081/cbi-120024220

    authors: Moussay S,Bessot N,Gauthier A,Larue J,Sesboüe B,Davenne D

    更新日期:2003-09-01 00:00:00

  • Systematic review of light exposure impact on human circadian rhythm.

    abstract::Light is necessary for life, and artificial light improves visual performance and safety, but there is an increasing concern of the potential health and environmental impacts of light. Findings from a number of studies suggest that mistimed light exposure disrupts the circadian rhythm in humans, potentially causing fu...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2018.1527773

    authors: Tähkämö L,Partonen T,Pesonen AK

    更新日期:2019-02-01 00:00:00

  • Common migraine as a weekly and seasonal headache.

    abstract::The aim of this study was to demonstrate that a possible recurrence may pertain to migraine attacks (MAs). The study was carried out by checking the personal diaries of 30 migraine sufferers ("migraineurs") who carefully annotated the date of their MA over twelve consecutive months. The group was composed of 15 males ...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420529009059158

    authors: Cugini P,Romit A,Di Palma L,Giacovazzo M

    更新日期:1990-01-01 00:00:00

  • When work calls-associations between being contacted outside of regular working hours for work-related matters and health.

    abstract::Boundaries between work and private life are diminishing, but little is known on how this influences worker health. Therefore, we examined the association between work-related contacts outside of regular working hours by e-mail or phone and self-reported health in a representative sample of European employees (n = 23 ...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2013.800089

    authors: Arlinghaus A,Nachreiner F

    更新日期:2013-11-01 00:00:00

  • Seasonal variation of body weight loss after bariatric surgery.

    abstract::Seasonal variations have been described in humans in several variables such as sleep, mood, appetite, food preferences, or body weight. We hypothesized that these variations could also influence the decrease in body weight rate in patients submitted to body weight loss interventions. Thus, here we tested the variation...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2019.1580716

    authors: Cambras T,Pardina E,Carmona J,Ricart-Jane D,Minarro A,Ferrer R,Lecube A,Balibrea JM,Caubet E,González O,Vilallonga R,Cuello E,Fort JM,Baena-Fustegueras JA,Díez-Noguera A,Peinado-Onsurbe J

    更新日期:2019-05-01 00:00:00

  • Effects of light on the circadian activity rhythm of Djungarian hamsters (Phodopus sungorus) with delayed activity onset.

    abstract::A number of Djungarian hamsters (Phodopus sungorus) of our institute show activity patterns that seem incompatible with proper adjustment to a periodic environment. The activity onset of those animals is continuously delayed, whereas the activity offset is stably coupled to "lights-on", leading to compression of activ...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420520903398583

    authors: Schottner K,Weinert D

    更新日期:2010-01-01 00:00:00

  • Spatiotemporal variability in activity patterns of urban street cattle as function of environmental factors.

    abstract::In the current study, we studied behavioral patterns, such as foraging, activity, standing, and laying in a population of cattle wandering on streets of Raipur city. We also determined the effects of four environmental factors (temperature, humidity, light, and noise intensities) on these behaviors. We recorded all fo...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2019.1644345

    authors: Sahu BK,Parganiha A,Pati AK

    更新日期:2019-10-01 00:00:00

  • Chronic ethanol intake alters circadian period-responses to brief light pulses in rats.

    abstract::Although chronic alcohol intake is associated with widespread disruptions of sleep-wake cycles and other daily biological rhythms in both human alcoholics and experimental animals, the extent to which the chronobiological effects of alcohol are mediated by effects on the underlying circadian pacemaker remains unknown....

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1081/cbi-200053496

    authors: Rosenwasser AM,Logan RW,Fecteau ME

    更新日期:2005-01-01 00:00:00

  • Sleep quality, chronotype and metabolic syndrome components in bipolar disorders during the remission period: Results from the FACE-BD cohort.

    abstract::Data on sleep or circadian abnormalities and metabolic disturbances in euthymic bipolar disorders are scarce and based on small sample sizes. The aim of this study was to explore the associations between sleep disturbances, chronotype and metabolic components in a large sample of euthymic patients with bipolar disorde...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2017.1332071

    authors: Godin O,Henry C,Leboyer M,Azorin JM,Aubin V,Bellivier F,Polosan M,Courtet P,Gard S,Kahn JP,Loftus J,Passerieux C,Costagliola D,Etain B

    更新日期:2017-01-01 00:00:00

  • Embryonic development and maternal regulation of murine circadian clock function.

    abstract::The importance of circadian clocks in the regulation of adult physiology in mammals is well established. In contrast, the ontogenesis of the circadian system and its role in embryonic development are still poorly understood. Although there is experimental evidence that the clock machinery is present prior to birth, da...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2014.986576

    authors: Landgraf D,Achten C,Dallmann F,Oster H

    更新日期:2015-04-01 00:00:00

  • Effects of CLOCK gene variants and early stress on hopelessness and suicide in bipolar depression.

    abstract:BACKGROUND:Patients with mood disorders show a high dependence of behavior on the molecular characteristics of the biological clock. CLOCK rs1801260 gene polymorphism influences circadian behavior in bipolar disorder (BD), with *C carriers showing a delayed sleep onset and worse insomnia. Sleep phase delay and insomnia...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2015.1060603

    authors: Benedetti F,Riccaboni R,Dallaspezia S,Locatelli C,Smeraldi E,Colombo C

    更新日期:2015-01-01 00:00:00

  • Weight gain and body mass index following change from daytime to night shift - a panel study with nursing professionals.

    abstract::We analyzed the association between change in work schedule and modifications in nutritional status. We performed a panel study with nursing professionals based on two surveys seven year apart (n = 372). Groups with no change in work schedule, change from daytime to night shift, and change from night to daytime shift ...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2016.1167719

    authors: Siqueria K,Griep R,Rotenberg L,Silva-Costa A,Mendes da Fonseca Mde J

    更新日期:2016-01-01 00:00:00

  • Reversal learning deficits during sleep deprivation: investigating the role of information acquisition failures.

    abstract::Besides degrading vigilant attention, total sleep deprivation (TSD) impairs reversal learning performance and blunts affective reactions to feedback. Whether these effects are downstream consequences of information acquisition failures from degraded vigilant attention, or distinct from degraded vigilant attention, is ...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2020.1819306

    authors: Lawrence-Sidebottom D,Hinson JM,Whitney P,Van Dongen HPA,Honn KA

    更新日期:2020-09-22 00:00:00

  • Light at night and melatonin have opposite effects on breast cancer tumors in mice assessed by growth rates and global DNA methylation.

    abstract::Light-at-night (LAN) is a worldwide problem co-distributed with breast cancer prevalence. We hypothesized that exposure to LAN is coincided with a decreased melatonin (MLT) secretion level, followed by epigenetic modifications and resulted in higher breast cancer tumors growth-rate. Accordingly, we studied the effect ...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2013.842925

    authors: Schwimmer H,Metzer A,Pilosof Y,Szyf M,Machnes ZM,Fares F,Harel O,Haim A

    更新日期:2014-02-01 00:00:00

  • Seasonal postembryonic maturation of the diurnal rhythm of serotonin in the chicken pineal gland.

    abstract::Previously, we have demonstrated the postembryonic development of chicken (Gallus gallus domesticus L.) pineal gland functions expressed as changes in melatonin (MEL) biosynthesis. Pineal concentrations of MEL and its precursor serotonin (5-HT) were shown to increase between the 2nd and 16th day of life. We also found...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2014.955185

    authors: Piesiewicz A,Kedzierska U,Turkowska E,Adamska I,Majewski PM

    更新日期:2015-02-01 00:00:00

  • Circadian rhythm of blood pressure in congestive heart failure and effects of ACE inhibitors.

    abstract::In 33 patients with heart failure (NYHA II-III), the 24-h blood pressure rhythm was examined before and after the titration period of two ACE inhibitors. Blood pressure was measured by the oscillometric method using the blood pressure monitor 90202 from SpaceLabs, Inc. The measurements were taken from 06:00 to 22:00 h...

    journal_title:Chronobiology international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/07420529109059177

    authors: Osterziel KJ,Dietz R,Lemmer B

    更新日期:1991-01-01 00:00:00

  • 24-hour pattern of work-related injury risk of French firemen: nocturnal peak time.

    abstract::The first aim of the study was to assess clock-time patterning of work-related injuries (WRIs) of firemen (FM) of Saône et Loire-71 (France) during the 4-yr span of 1 January 2004 to 31 December 2007. FM of this service are legally required to log every WRI and seek its evaluation by the medical service, whether the W...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2011.603170

    authors: Riedel M,Berrez S,Pelisse D,Brousse E,Forget C,Marlot M,Smolensky MH,Touitou Y,Reinberg A

    更新日期:2011-10-01 00:00:00

  • How well does a commercially available wearable device measure sleep in young athletes?

    abstract::The validity of a commercially available wearable device for measuring total sleep time was examined in a sample of well-trained young athletes during night-time sleep periods and daytime naps. Participants wore a FitBit HR Charge on their non-dominant wrist and had electrodes attached to their face and scalp to enabl...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2018.1466800

    authors: Sargent C,Lastella M,Romyn G,Versey N,Miller DJ,Roach GD

    更新日期:2018-06-01 00:00:00

  • Thermoregulatory effects of melatonin in relation to sleepiness.

    abstract::Thermoregulatory processes have long been implicated in the initiation of human sleep. In this paper, we review our own studies conducted over the last decade showing a crucial role for melatonin as a mediator between the thermoregulatory and arousal system in humans. Distal heat loss, via increased skin temperature, ...

    journal_title:Chronobiology international

    pub_type: 杂志文章,评审

    doi:10.1080/07420520500545854

    authors: Kräuchi K,Cajochen C,Pache M,Flammer J,Wirz-Justice A

    更新日期:2006-01-01 00:00:00

  • Identification of human plasma metabolites exhibiting time-of-day variation using an untargeted liquid chromatography-mass spectrometry metabolomic approach.

    abstract::Although daily rhythms regulate multiple aspects of human physiology, rhythmic control of the metabolome remains poorly understood. The primary objective of this proof-of-concept study was identification of metabolites in human plasma that exhibit significant 24-h variation. This was assessed via an untargeted metabol...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2012.699122

    authors: Ang JE,Revell V,Mann A,Mäntele S,Otway DT,Johnston JD,Thumser AE,Skene DJ,Raynaud F

    更新日期:2012-08-01 00:00:00