Diurnal redistribution of human lymphocytes and their temporal associations with salivary cortisol.

Abstract:

:Immune cell trafficking is crucial for surveillance and effector functions of the immune system. Circadian rhythms of the hypothalamic-pituitary-adrenal (HPA) axis and of cortisol have been implicated in circadian redistribution of circulating lymphocytes and granulocytes. However, information regarding the diurnal redistribution of immune cells and their temporal correlations with cortisol is scarce. In this study, we investigated the diurnal redistribution of T, B, and natural killer (NK) cell subsets in relation to the endogenous cortisol rhythm. Saliva and blood samples were collected every 15 min over an 8-h period. Salivary-free cortisol was measured by enzyme-linked immunosorbent assay (ELISA). Surface markers (CD3, CD19, CD8, CD56, CD16, KIR) were measured in whole blood samples by 6-color flow cytometry and cell subsets quantified as a percentage of the total lymphocyte population. To study associations between the diurnal cortisol rhythm and the redistribution of T, B, and NK cells, we calculated cross-correlations with lag periods of 15 min. The salivary cortisol levels showed the typical diurnal variations with a significant morning cortisol awakening response (CAR) peaking around 07:30 h followed by an afternoon nadir. Whereas B cells remained stable throughout the 8 h, T cells (CD3 + CD8+ and CD3 + CD8-) showed a significant positive cross-correlation with cortisol levels when a delay of 30-105 min was taken into account. This was followed by a negative correlation covering a period of 165-285 min after the cortisol peak. Conversely, NK cells showed an initial negative correlation at 45-105 min, followed by a positive correlation at 120-285 min. The major CD56 + CD16+ subset and the CD56 - CD16+ population showed similar temporal correlation profiles. The minor CD56 + CD16- NK cell subset showed no temporal changes. The major NK subset (CD56 + CD16+) contains cells with higher cytolytic activity (KIR+) cells, whereas the single-positive subsets CD56 + CD16- and CD56 - CD16+ are mainly involved in cytokine production. Significant positive correlations were observed in KIR+ subsets coincident with this of NK cells covering a period of 105-300 min after the cortisol peak. In conclusion, our results suggest that cortisol and the HPA axis orchestrate tidal waves of immune cells that are alternatively based toward innate and acquired immune surveillance.

journal_name

Chronobiol Int

authors

Trifonova ST,Zimmer J,Turner JD,Muller CP

doi

10.3109/07420528.2013.775654

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

669-81

issue

5

eissn

0742-0528

issn

1525-6073

journal_volume

30

pub_type

杂志文章
  • The birth of chronobiology: Julien Joseph Virey 1814.

    abstract::Julien-Joseph Virey (1775-1846) held the position of pharmacist-in-chief at the Val-de-Grâce, a military hospital. He was an innovative pharmacist, naturalist, anthropologist, and philosopher and a prolific author. His writings encompassed a wide range of topics, although many of his ideas were sometimes harshly quest...

    journal_title:Chronobiology international

    pub_type: 传,历史文章,杂志文章

    doi:10.1081/cbi-100103184

    authors: Reinberg AE,Lewy H,Smolensky M

    更新日期:2001-03-01 00:00:00

  • The effect of experimental diabetes on the twenty-four-hour pattern of the vasodilator responses to acetylcholine and isoprenaline in the rat aorta.

    abstract::The aim of this study was to investigate whether time-dependent variations in the relaxant effect of acetylcholine, an endothelium-dependent vasorelaxant via muscarinic receptors, and isoprenaline, a nonselective beta-adrenoceptor agonist in rat aorta, are influenced by streptozotocin (STZ)-induced experimental diabet...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420520701795332

    authors: Uluoglu C,Durakoglugil DB,Karasu C,Ozbey G,Gunes A,Zengil H

    更新日期:2007-01-01 00:00:00

  • Modeling inter-sex and inter-individual variability in response to chronopharmacological administration of synthetic glucocorticoids.

    abstract::Endogenous glucocorticoids have diverse physiological effects and are important regulators of metabolism, immunity, cardiovascular function, musculoskeletal health and central nervous system activity. Synthetic glucocorticoids have received widespread attention for their potent anti-inflammatory activity and have beco...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2019.1660357

    authors: Scherholz ML,Rao RT,Androulakis IP

    更新日期:2020-02-01 00:00:00

  • Diurnal modulation of visual motion prediction.

    abstract::Predicting the future position of moving objects is an essential cognitive function used for many daily activities, such as driving, walking and reaching. The experiments described in this paper show a marked diurnal modulation of motion prediction in inflating image perception. This motion prediction was shown to be ...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2015.1053564

    authors: Takao M,Miyajima H,Shinagawa T

    更新日期:2015-01-01 00:00:00

  • Associations between chronotypes and psychological vulnerability factors of depression.

    abstract::Chronotypes have been associated with psychopathology. The eveningness chronotype has been consistently linked with depressed states or depressive disorder, but the underlying mechanism remains unclear. Prior studies have shown associations between chronotype and personality traits that are linked to depression (e.g. ...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2017.1345932

    authors: Antypa N,Verkuil B,Molendijk M,Schoevers R,Penninx BWJH,Van Der Does W

    更新日期:2017-01-01 00:00:00

  • Valsartan chronotherapy reverts the non-dipper pattern and improves blood pressure control through mediation of circadian rhythms of the renin-angiotensin system in spontaneous hypertension rats.

    abstract::Background: Numerous clinical studies have evaluated valsartan and found more efficacious control of blood pressure (BP) variability when administered before sleep. The treatment leads to improved outcomes when compared to administration upon awakening. The mechanism underlying this etiology is not fully understood. T...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2019.1610419

    authors: Yang K,Wang Y,Ding Y,Cui H,Zhou D,Chen L,Ma Z,Wang W,Zhang W,Luan J

    更新日期:2019-08-01 00:00:00

  • Diurnal sensitivity of the neuroendocrine-reproductive axis to the antigonadotrophic influence of melatonin in male Syrian hamsters with experimentally altered cortisol rhythms.

    abstract::Two different experimental models were used to test if a temporal relationship exists between the rhythm of adrenal steroid secretion and the vulnerability of the hamster reproductive system to short photoperiod exposure or to the daily afternoon injection of melatonin. In the first experiment adrenalectomized hamster...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528509055541

    authors: Joshi BN,Vaughan MK,Nürnberger F,Reiter RJ

    更新日期:1985-01-01 00:00:00

  • Pharmacological blockage of serotonin biosynthesis and circadian changes in oxaliplatin toxicity in rats.

    abstract::This study investigates if the serotoninergic system plays a role in chronotoxic effects of the anticancer agent oxaliplatin (l-OHP). Four groups of female rats (120 in total) synchronized with light-dark (12 h:12 h) were treated with: (i) saline, (ii) para-chlorophenylalanine (pCPA, an inhibitor of serotonin biosynth...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1081/cbi-120015957

    authors: Boughattas NA,Ben Attia M,Ixart G,Lemaigre G,Mechkouri M,Reinberg A

    更新日期:2002-11-01 00:00:00

  • Melatonin entrains free-running blind people according to a physiological dose-response curve.

    abstract::The specific circadian role proposed for endogenous melatonin production was based on a study of sighted people who took low pharmacological doses (500 microg) of this chemical signal for the "biological night": the magnitude and direction of the induced phase shifts were dependent on what time of day exogenous melato...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420520500398064

    authors: Lewy AJ,Emens JS,Lefler BJ,Yuhas K,Jackman AR

    更新日期:2005-01-01 00:00:00

  • Effect of chronic caloric restriction on the circadian regulation of physiological and behavioral variables in old male B6C3F1 mice.

    abstract::The circadian rhythms of food and water consumption, the number of feeding and drinking episodes, oxygen consumption, carbon dioxide production, respiratory quotient, gross motor activity, and body temperature were measured in male B6C3F1 mice that were fed ad libitum (AL) or fed a caloric-restricted diet (CR). The CR...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420529009064635

    authors: Duffy PH,Feuers RJ,Hart RW

    更新日期:1990-01-01 00:00:00

  • The relationship between workload, performance and fatigue in a short-haul airline.

    abstract::The aim of this study was to determine the relationship between pilot workload, performance, subjective fatigue, sleep duration, number of sectors and flight duration during short-haul operations. Ninety pilots completed a NASA Task Load Index, Psychomotor Vigilance Task and a Samn-Perelli fatigue scale on top-of-desc...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2020.1804924

    authors: Arsintescu L,Chachad R,Gregory KB,Mulligan JB,Flynn-Evans EE

    更新日期:2020-08-24 00:00:00

  • When work calls-associations between being contacted outside of regular working hours for work-related matters and health.

    abstract::Boundaries between work and private life are diminishing, but little is known on how this influences worker health. Therefore, we examined the association between work-related contacts outside of regular working hours by e-mail or phone and self-reported health in a representative sample of European employees (n = 23 ...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2013.800089

    authors: Arlinghaus A,Nachreiner F

    更新日期:2013-11-01 00:00:00

  • Epidemiological study on chronotype among preschool children in Japan: Prevalence, sleep-wake patterns, and associated factors.

    abstract::Our current 24-h society and the weekday-weekend switch of our social clocks may affect young children's sleep and circadian rhythms. However, such evidence is scarce. We conducted a nationwide epidemiological study of sleep and health in preschool children aged 3-5 years attending kindergarten or childcare centers in...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2016.1217231

    authors: Doi Y,Ishihara K,Uchiyama M

    更新日期:2016-01-01 00:00:00

  • A longitudinal large-scale objective sleep data analysis revealed a seasonal sleep variation in the Japanese population.

    abstract::In the contemporary era, when life habits are largely determined by social needs and individual preferences, sleep is nevertheless affected by seasonal environmental changes. Japan has large seasonal and geographical alterations of photoperiod and climate. Japan does not adopt the daylight saving time (DST) system, ma...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2018.1443118

    authors: Hashizaki M,Nakajima H,Shiga T,Tsutsumi M,Kume K

    更新日期:2018-07-01 00:00:00

  • Chronotype, gender, and time for sex.

    abstract::The study aimed at testing chronotype and gender differences in the time of day when humans feel the greatest need for sex and the time of day they actually undertake sexual activity. A Polish sample of 565 participants aged between 18 and 57 was tested. In females, regardless of chronotype, the greatest need for sex ...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2014.925470

    authors: Jankowski KS,Díaz-Morales JF,Randler C

    更新日期:2014-10-01 00:00:00

  • Systematic review of light exposure impact on human circadian rhythm.

    abstract::Light is necessary for life, and artificial light improves visual performance and safety, but there is an increasing concern of the potential health and environmental impacts of light. Findings from a number of studies suggest that mistimed light exposure disrupts the circadian rhythm in humans, potentially causing fu...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2018.1527773

    authors: Tähkämö L,Partonen T,Pesonen AK

    更新日期:2019-02-01 00:00:00

  • Spatiotemporal variability in activity patterns of urban street cattle as function of environmental factors.

    abstract::In the current study, we studied behavioral patterns, such as foraging, activity, standing, and laying in a population of cattle wandering on streets of Raipur city. We also determined the effects of four environmental factors (temperature, humidity, light, and noise intensities) on these behaviors. We recorded all fo...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2019.1644345

    authors: Sahu BK,Parganiha A,Pati AK

    更新日期:2019-10-01 00:00:00

  • Effect of Ramadan fasting on feelings, dietary intake, rating of perceived exertion and repeated high intensity short-term maximal performance.

    abstract::The present study was designed to investigate the effect of Ramadan fasting on feelings, dietary intake, rating of perceived exertion (RPE) and repeated high-intensity short-term maximal performance. Thirteen physically active men (age: 21.2 ± 2.9 years, height: 175.6 ± 5.6 cm, body-mass: 72.4 ± 8.6 kg) performed a 5-...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2018.1513943

    authors: Boukhris O,Hsouna H,Chtourou L,Abdesalem R,BenSalem S,Tahri N,Trabelsi K,Stannard SR,Chtourou H

    更新日期:2019-01-01 00:00:00

  • Brain photoreceptor pathways contributing to circadian rhythmicity in crayfish.

    abstract::Freshwater crayfish have three known photoreceptive systems: the compound eyes, extraretinal brain photoreceptors, and caudal photoreceptors. The primary goal of the work described here was to explore the contribution of the brain photoreceptors to circadian locomotory activity and define some of the underlying neural...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420520903217960

    authors: Sullivan JM,Genco MC,Marlow ED,Benton JL,Beltz BS,Sandeman DC

    更新日期:2009-08-01 00:00:00

  • Temporal variations of adenosine metabolism in human blood.

    abstract::Eight diurnally active (06:00-23:00 h) subjects were adapted for 2 days to the room conditions where the experiments were performed. Blood sampling for adenosine metabolites and metabolizing enzymes was done hourly during the activity span and every 30 min during sleep. The results showed that adenosine and its catabo...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420529609012650

    authors: Chagoya de Sánchez V,Hernández-Muñoz R,Suárez J,Vidrio S,Yáñez L,Aguilar-Roblero R,Oksenberg A,Vega-González A,Villalobos L,Rosenthal L,Fernández-Cancino F,Drucker-Colín R,Díaz-Muñoz M

    更新日期:1996-08-01 00:00:00

  • Relationships between chronotype, social jetlag, sleep, obesity and blood pressure in healthy young adults.

    abstract::Sleep disturbances, chronotype and social jetlag (SJL) have been associated with increased risks for major chronic diseases that take decades to develop, such as obesity, metabolic syndrome and cardiovascular disease. Potential relationships between poor sleep, chronotype and SJL as they relate to metabolic risk facto...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2018.1563094

    authors: McMahon DM,Burch JB,Youngstedt SD,Wirth MD,Hardin JW,Hurley TG,Blair SN,Hand GA,Shook RP,Drenowatz C,Burgess S,Hebert JR

    更新日期:2019-04-01 00:00:00

  • Facebook use and chronotype: Results of a cross-sectional study.

    abstract::Facebook has become the most popular social networking site round the world. In seeking an explanation for this phenomenon, individual differences in circadian functioning seem to be an interesting issue. The main aim of this study was to examine the potential associations between morningness/eveningness and Facebook ...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2015.1083998

    authors: Blachnio A,Przepiorka A,Díaz-Morales JF

    更新日期:2015-01-01 00:00:00

  • Differences in toxicity and outcome associated with circadian variations between patients undergoing daytime and evening radiotherapy for prostate adenocarcinoma.

    abstract::This retrospective study tested the hypothesis that disease control and treatment-related toxicity in patients undergoing high-dose radiotherapy (HDRT) for prostate cancer varies in a circadian manner. Patients with localized prostate adenocarcinoma receiving HDRT (median 78 Gy) to the prostate and involved seminal ve...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2015.1130049

    authors: Hsu FM,Hou WH,Huang CY,Wang CC,Tsai CL,Tsai YC,Yu HJ,Pu YS,Cheng JC

    更新日期:2016-01-01 00:00:00

  • Proxisome proliferator-activated receptor-α mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice.

    abstract::Acute thrombotic events frequently occur in the early morning among hyperlipidemic patients. The activity of plasminogen activator inhibitor-1 (PAI-1), a potent inhibitor of the fibrinolytic system, oscillates daily, and this is considered one mechanism that underlies the morning onset of acute thrombotic events in hy...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2010.515324

    authors: Hayashida S,Kuramoto Y,Koyanagi S,Oishi K,Fujiki J,Matsunaga N,Ikeda E,Ohdo S,Shimeno H,Soeda S

    更新日期:2010-10-01 00:00:00

  • Time course of neurobehavioral alertness during extended wakefulness in morning- and evening-type healthy sleepers.

    abstract::The aim of the study was to evaluate the influence of chronotype (morning-type versus evening-type) living in a fixed sleep-wake schedule different from one's preferred sleep schedules on the time course of neurobehavioral performance during controlled extended wakefulness. The authors studied 9 morning-type and 9 eve...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2011.590623

    authors: Taillard J,Philip P,Claustrat B,Capelli A,Coste O,Chaumet G,Sagaspe P

    更新日期:2011-07-01 00:00:00

  • Association between specific diurnal preference questionnaire items and PER3 VNTR genotype.

    abstract::Although there are significant intra-individual differences in self-reported diurnal preference, as measured by validated questionnaires, the relative contribution of exogenous and endogenous factors to self-reported diurnal preference largely remains to be investigated. The present study examined which items from the...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420520902820970

    authors: Ellis J,von Schantz M,Jones KH,Archer SN

    更新日期:2009-04-01 00:00:00

  • Salivary cortisol concentration after high-intensity interval exercise: Time of day and chronotype effect.

    abstract::Due to personal and working necessities, the time for exercise is often short, and scheduled early in the morning or late in the afternoon. Cortisol plays a central role in the physiological and behavioral response to a physical challenge and can be considered as an index of exercise stress. Therefore, the aim of this...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.1080/07420528.2017.1311336

    authors: Bonato M,La Torre A,Saresella M,Marventano I,Merati G,Vitale JA

    更新日期:2017-01-01 00:00:00

  • Effects of a chronic reduction of short-wavelength light input on melatonin and sleep patterns in humans: evidence for adaptation.

    abstract::Light is an important environmental stimulus for the entrainment of the circadian clock and for increasing alertness. The intrinsically photosensitive ganglion cells in the retina play an important role in transferring this light information to the circadian system and they are elicited in particular by short-waveleng...

    journal_title:Chronobiology international

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/07420528.2014.893242

    authors: Giménez MC,Beersma DG,Bollen P,van der Linden ML,Gordijn MC

    更新日期:2014-06-01 00:00:00

  • Irradiation with X-rays phase-advances the molecular clockwork in liver, adrenal gland and pancreas.

    abstract::The circadian clock of man and mammals shows a hierarchic organization. The master clock, located in the suprachiasmatic nuclei (SCN), controls peripheral oscillators distributed throughout the body. Rhythm generation depends on molecular clockworks based on transcriptional/translational interaction of clock genes. Nu...

    journal_title:Chronobiology international

    pub_type: 杂志文章

    doi:10.3109/07420528.2014.949735

    authors: Müller MH,Rödel F,Rüb U,Korf HW

    更新日期:2015-02-01 00:00:00

  • Some perturbations that disturb the circadian melatonin rhythm.

    abstract::The circadian melatonin rhythm is highly reproducible and generally not easily altered. The few perturbations that are capable of significantly changing either the amplitude or the pattern of the 24-h melatonin rhythm are summarized herein. Aging alters cyclic melatonin production by decreasing the amplitude of the no...

    journal_title:Chronobiology international

    pub_type: 杂志文章,评审

    doi:10.3109/07420529209064541

    authors: Reiter RJ,Richardson BA

    更新日期:1992-08-01 00:00:00