Abstract:
:Eight diurnally active (06:00-23:00 h) subjects were adapted for 2 days to the room conditions where the experiments were performed. Blood sampling for adenosine metabolites and metabolizing enzymes was done hourly during the activity span and every 30 min during sleep. The results showed that adenosine and its catabolites (inosine, hypoxanthine, and uric acid), adenosine synthesizing (S-adenosylhomocysteine hydrolase and 5'-nucleotidase), degrading (adenosine deaminase) and nucleotide-forming (adenosine kinase) enzymes as well as adenine nucleotides (AMP, ADP, and ATP) undergo statistically significant fluctuations (ANOVA) during the 24 h. However, energy charge was invariable. Glucose and lactate chronograms were determined as metabolic indicators. The same data analyzed by the chi-square periodogram and Fourier series indicated ultradian oscillatory periods for all the metabolites and enzymatic activities determined, and 24-h oscillatory components for inosine, hypoxanthine, adenine nucleotides, glucose, and the activities of SAH-hydrolase, 5'-nucleotidase, and adenosine kinase. The single cosinor method showed significant oscillatory components exclusively for lactate. As a whole, these results suggest that adenosine metabolism may play a role as a biological oscillator coordinating and/or modulating the energy homeostasis and physiological status of erythrocytes in vivo and could be an important factor in the distribution of purine rings for the rest of the organism.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Chagoya de Sánchez V,Hernández-Muñoz R,Suárez J,Vidrio S,Yáñez L,Aguilar-Roblero R,Oksenberg A,Vega-González A,Villalobos L,Rosenthal L,Fernández-Cancino F,Drucker-Colín R,Díaz-Muñoz Mdoi
10.3109/07420529609012650subject
Has Abstractpub_date
1996-08-01 00:00:00pages
163-77issue
3eissn
0742-0528issn
1525-6073journal_volume
13pub_type
杂志文章abstract::A synopsis of the effects of exercise on the circadian system in nocturnal rodents is followed by a review of the few studies investigating the influence of exercise on the human circadian system. It is premature to make specific recommendations about using exercise to promote synchronization in people because of the ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
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abstract::Few studies have focused on the influence of circadian typology on drug use, and none has considered the use of illegal drugs and hazardous alcohol consumption. This study analyzes the influence of circadian typology on several types of drug consumption (habitual or sporadic), hangover symptoms (past 12 mos), and, mor...
journal_title:Chronobiology international
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abstract::Ninety-five nonresident girls of a private school volunteered for the study with the teachers' help as well as parental consent. Ages were approximately 8, 9, and 10 years. They were synchronized with diurnal activity from 0730 to 2100 h and nocturnal rest. Fatigue, drowsiness, and attention were self-rated using visu...
journal_title:Chronobiology international
pub_type: 杂志文章
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
pub_type: 杂志文章,评审
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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