Melatonin entrains free-running blind people according to a physiological dose-response curve.

Abstract:

:The specific circadian role proposed for endogenous melatonin production was based on a study of sighted people who took low pharmacological doses (500 microg) of this chemical signal for the "biological night": the magnitude and direction of the induced phase shifts were dependent on what time of day exogenous melatonin was administered and were described by a phase-response curve that turned out to be the opposite of that for light. We now report that lower (physiological) doses of up to 300 microg can entrain (synchronize) free-running circadian rhythms of 10 totally blind subjects that would otherwise drift later each day. The resulting log-linear dose-response curve in the physiological range adds support for a circadian function of endogenous melatonin in humans. Efficacy of exogenous doses in the physiological range are of clinical significance for totally blind people who will need to take melatonin daily over their entire lifetimes in order to remain entrained to the 24 h day. Left untreated, their free-running endocrine, metabolic, behavioral, and sleep/wake cycles can be almost as burdensome as not having vision.

journal_name

Chronobiol Int

authors

Lewy AJ,Emens JS,Lefler BJ,Yuhas K,Jackman AR

doi

10.1080/07420520500398064

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

1093-106

issue

6

eissn

0742-0528

issn

1525-6073

pii

RL876X5P42U2L6Q1

journal_volume

22

pub_type

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