Abstract:
:The specific circadian role proposed for endogenous melatonin production was based on a study of sighted people who took low pharmacological doses (500 microg) of this chemical signal for the "biological night": the magnitude and direction of the induced phase shifts were dependent on what time of day exogenous melatonin was administered and were described by a phase-response curve that turned out to be the opposite of that for light. We now report that lower (physiological) doses of up to 300 microg can entrain (synchronize) free-running circadian rhythms of 10 totally blind subjects that would otherwise drift later each day. The resulting log-linear dose-response curve in the physiological range adds support for a circadian function of endogenous melatonin in humans. Efficacy of exogenous doses in the physiological range are of clinical significance for totally blind people who will need to take melatonin daily over their entire lifetimes in order to remain entrained to the 24 h day. Left untreated, their free-running endocrine, metabolic, behavioral, and sleep/wake cycles can be almost as burdensome as not having vision.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Lewy AJ,Emens JS,Lefler BJ,Yuhas K,Jackman ARdoi
10.1080/07420520500398064subject
Has Abstractpub_date
2005-01-01 00:00:00pages
1093-106issue
6eissn
0742-0528issn
1525-6073pii
RL876X5P42U2L6Q1journal_volume
22pub_type
杂志文章abstract::We ask if epidemiological studies into shift work and cancer may be prone to chronobiological errors. We illustrate how ignoring internal time (IT), or chronotype, may lead to what we call IT errors. Errors from truncating relevant external time (ET) information (activities start before and do not end with the shift) ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.877921
更新日期:2014-05-01 00:00:00
abstract::In this study, we aimed to show how age affects hibernation in the Syrian hamster. Experimentally, we used 30 male animals differing in age. The old animals were 20 months of age and the adults were 8 months of age at the end of the test. The young animals were 3 weeks old at the start of testing and 5 months old at t...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100101069
更新日期:2000-09-01 00:00:00
abstract::In two experiments, triazolam (2.5 and 1.5 mg/animal) failed to significantly enhance the rate of reentrainment of hamsters (Mesocricetus auratus) to an 8-hr advance of their light-dark cycle. Evidently the phase-shifting effects of triazolam are not robust. The animals did not run much in their wheels in response to ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529009056952
更新日期:1990-01-01 00:00:00
abstract::Dysregulation of the system of nitric oxide (NO)-cyclic 3',5'-guanosine monophosphate (cGMP) might be involved in the development of hypertension in transgenic hypertensive TGR(mREN2)27 (TGR) rats. The present study was performed to determine possible differences in the day-night pattern and the urinary excretion rate...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529909116860
更新日期:1999-05-01 00:00:00
abstract::A number of Djungarian hamsters (Phodopus sungorus) of our institute show activity patterns that seem incompatible with proper adjustment to a periodic environment. The activity onset of those animals is continuously delayed, whereas the activity offset is stably coupled to "lights-on", leading to compression of activ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420520903398583
更新日期:2010-01-01 00:00:00
abstract::This study aimed to verify the prevalence and factors associated with excessive daytime sleepiness (EDS) among adolescents. In all, 1.132 people participated. They were aged between 14 and 19 years, of both sexes and they came from a city in southern Brazil. Many socio-demographic variables were collected (sex, age gr...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1633661
更新日期:2019-09-01 00:00:00
abstract::We analyzed the association between change in work schedule and modifications in nutritional status. We performed a panel study with nursing professionals based on two surveys seven year apart (n = 372). Groups with no change in work schedule, change from daytime to night shift, and change from night to daytime shift ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2016.1167719
更新日期:2016-01-01 00:00:00
abstract::Nonrestorative sleep (NRS), characterized by a lack of refreshment upon awakening, has received little attention in the sleep literature even though it can occur and cause impairment apart from other sleep difficulties associated with insomnia. The Restorative Sleep Questionnaire (RSQ) is one of the first validated se...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2016.1212870
更新日期:2016-01-01 00:00:00
abstract::The degu (Octodon degus) is a diurnal rodent, although phase inversions to nocturnal behavior have been reported under specific laboratory conditions. The reliability of this animal as a diurnal model of sleep therefore requires further characterization of intrinsic circadian pacemaker properties. A phase response cur...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701420352
更新日期:2007-01-01 00:00:00
abstract::The circadian rhythms of food and water consumption, the number of feeding and drinking episodes, oxygen consumption, carbon dioxide production, respiratory quotient, gross motor activity, and body temperature were measured in male B6C3F1 mice that were fed ad libitum (AL) or fed a caloric-restricted diet (CR). The CR...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420529009064635
更新日期:1990-01-01 00:00:00
abstract::The circadian clock regulates many cellular processes, notably including the cell cycle, metabolism and aging. Mitochondria play essential roles in metabolism and are the major sites of reactive oxygen species (ROS) production in the cell. The clock regulates mitochondrial functions by driving daily changes in NAD(+) ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1085388
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Morning stiffness and plasma cytokine levels in rheumatoid arthritis (RA) patients exhibit 24-hour variations. Tumor necrosis factor-α (TNF-α) plays a central role in RA clinical conditions, including the invasion of inflammatory cells, destruction of cartilage, systemic inflammatory response and its levels s...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.878350
更新日期:2014-05-01 00:00:00
abstract::A variable number tandem repeat polymorphism (VNTR) in the period 3 (PER3) gene has been associated with heritable sleep and circadian variables, including self-rated chronotypes, polysomnographic (PSG) variables, insomnia and circadian sleep-wake disorders. This report describes novel molecular and clinical analyses ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1287083
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to examine the impact of brief, unscheduled naps during work periods on alertness and vigilance in coastal pilots along the Great Barrier Reef. On certain routes, the duration of the work period can extend well beyond 24 h. Seventeen coastal pilots volunteered for the study, representing almo...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520802106819
更新日期:2008-04-01 00:00:00
abstract::The phase and period responses to short light pulses were studied in the jerboa, a seasonal, hibernating, nocturnal rodent from the Atlas region in Morocco. The jerboa, which is a saltatory species, showed precise activity onsets and offsets under a light-dark (LD) cycle using infrared captors to record locomotor acti...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2010.504315
更新日期:2010-08-01 00:00:00
abstract::Postoperative delirium, a common perioperative complication, is frequently observed in elderly surgical patients. Few studies have investigated the life rhythm of preoperative patients, and whether or not the preoperative life rhythm is associated with the development of postoperative delirium. The purpose of this stu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1764012
更新日期:2020-07-01 00:00:00
abstract::Dysfunctional regulation of brain dopamine (DA) functions has been found in patients with drug addiction and various neurological disorders that frequently accompany disturbance in sleep behavior. In this study, the roles of the dopaminergic nervous system on the regulation of daily locomotor activity rhythm were inve...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.741169
更新日期:2013-05-01 00:00:00
abstract::The aim of this study was to demonstrate that a possible recurrence may pertain to migraine attacks (MAs). The study was carried out by checking the personal diaries of 30 migraine sufferers ("migraineurs") who carefully annotated the date of their MA over twelve consecutive months. The group was composed of 15 males ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529009059158
更新日期:1990-01-01 00:00:00
abstract::Thermoregulatory processes have long been implicated in the initiation of human sleep. In this paper, we review our own studies conducted over the last decade showing a crucial role for melatonin as a mediator between the thermoregulatory and arousal system in humans. Distal heat loss, via increased skin temperature, ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1080/07420520500545854
更新日期:2006-01-01 00:00:00
abstract::The present study was designed to investigate the effect of Ramadan fasting on feelings, dietary intake, rating of perceived exertion (RPE) and repeated high-intensity short-term maximal performance. Thirteen physically active men (age: 21.2 ± 2.9 years, height: 175.6 ± 5.6 cm, body-mass: 72.4 ± 8.6 kg) performed a 5-...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1513943
更新日期:2019-01-01 00:00:00
abstract::In the contemporary era, when life habits are largely determined by social needs and individual preferences, sleep is nevertheless affected by seasonal environmental changes. Japan has large seasonal and geographical alterations of photoperiod and climate. Japan does not adopt the daylight saving time (DST) system, ma...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1443118
更新日期:2018-07-01 00:00:00
abstract::Behavior, physiological functions and cognitive performance change over the time of the day. These daily rhythms are either externally driven by rhythmic environmental cues such as the light/dark cycle (masking) or controlled by an internal circadian clock, the suprachiasmatic nucleus (SCN), which can be entrained to ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.956218
更新日期:2015-02-01 00:00:00
abstract::Fourteen ambulatory subjects, varying in their amount of habitual physical activity, were studied for 24 h during a total of 25 "typical" days. Rectal temperature was recorded every 6 minutes, an activity diary was filled in every half hour, and wrist activity and heart rate were monitored every minute. Actimetry and ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529908998721
更新日期:1999-07-01 00:00:00
abstract::Changes in the free-running period of the circadian rhythms of hamsters occur after single nonphotic events such as a 3-h pulse of running induced by being put in a novel wheel. These changes are mostly in the direction of longer periods, and can exceed 0.2 h; the magnitude of the effect depends on the circadian phase...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529309059709
更新日期:1993-08-01 00:00:00
abstract::In the current study, we studied behavioral patterns, such as foraging, activity, standing, and laying in a population of cattle wandering on streets of Raipur city. We also determined the effects of four environmental factors (temperature, humidity, light, and noise intensities) on these behaviors. We recorded all fo...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1644345
更新日期:2019-10-01 00:00:00
abstract::Total sleep deprivation (TSD) is known to impair sustained attention. However, previously reported effects of TSD on response inhibition are mixed. We administered a "stop-signal" variation of the psychomotor vigilance test, which included 25% of trials requiring withholding of a response to assess response inhibition...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1811718
更新日期:2020-08-25 00:00:00
abstract::The present article analyzes locomotor activity rhythms in Tinca tinca. To that end, three different experiments were conducted on 24 animals (20 g body weight) kept in pairs in 60-liter aquaria fitted with infrared sensors connected to a computer to continuously record fish movements. The first experiment was designe...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120025246
更新日期:2003-11-01 00:00:00
abstract::Fatigue is an increasingly noted factor in road accidents. The ability to predict and be aware of impairment in terms of driving capability is important for potential legal liability and road safety. However, to date, there have been few studies that have investigated the accuracy of individuals in predicting how safe...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520601083391
更新日期:2006-01-01 00:00:00
abstract::In order to optimize chronotherapeutic schedules (designs), we examined the interindividual differences in chronopharmacologic effects of drugs with consideration of the following three factors: (a) inherited factors of direct relevance to chronopharmacology (genetic variability, gender-related differences) as well as...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529309059721
更新日期:1993-12-01 00:00:00
abstract::The circalunidian-clock hypothesis is a formulation describing the means by which the tide-associated rhythms of intertidal organisms are generated. The postulate was described in a 1995 article in this journal (12:299-310). A recent paper published here (13:153-62) by Prof. Ernest Naylor challenges the validity of th...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529709001455
更新日期:1997-07-01 00:00:00