Abstract:
:Thermoregulatory processes have long been implicated in the initiation of human sleep. In this paper, we review our own studies conducted over the last decade showing a crucial role for melatonin as a mediator between the thermoregulatory and arousal system in humans. Distal heat loss, via increased skin temperature, seems to be intimately coupled with increased sleepiness and sleep induction. Exogenous melatonin administration during the day when melatonin is essentially absent mimics the endogenous thermophysiological processes occurring in the evening and induces sleepiness. Using a cold thermic challenge test, it was shown that melatonin-induced sleepiness occurs in parallel with reduction in the thermoregulatory set-point (threshold); thus, melatonin may act as a circadian modulator of the thermoregulatory set-point. In addition, an orthostatic challenge can partially block the melatonin-induced effects, suggesting an important role of the sympathetic nervous system as a link between the thermoregulatory and arousal systems. A topographical analysis of finger skin temperature with infrared thermometry revealed that the most distal parts of the fingers, i.e., fingertips, represent the important skin regions for heat loss regulation, most probably via opening the arteriovenous anastomoses, and this is clearly potentiated by melatonin. Taken together, melatonin is involved in the fine-tuning of vascular tone in selective vascular beds, as circulating melatonin levels rise and fall throughout the night. Besides the role of melatonin as "nature's soporific", it can also serve as nature's nocturnal vascular modulator.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Kräuchi K,Cajochen C,Pache M,Flammer J,Wirz-Justice Adoi
10.1080/07420520500545854subject
Has Abstractpub_date
2006-01-01 00:00:00pages
475-84issue
1-2eissn
0742-0528issn
1525-6073pii
K0340276X3700740journal_volume
23pub_type
杂志文章,评审abstract::The evening chronotype is strongly associated with greater alcohol use, though mechanisms underlying this association are not well understood. The current study evaluated emotion regulation as a potential mechanism linking evening chronotype and alcohol use. Participants were 81 undergraduate students. Chronotype was ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1800028
更新日期:2020-12-01 00:00:00
abstract::Biological clock components have been detected in many epithelial tissues of the digestive tract of mammals (oral mucosa, pancreas, and liver), suggesting the existence of peripheral circadian clocks that may be entrainable by food. Our aim was to investigate the expression of main peripheral clock genes in colonocyte...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520500395011
更新日期:2005-01-01 00:00:00
abstract::Hyperphosphatemia is a common complication of chronic kidney disease (CKD) and is associated with cardiovascular disease (CVD), which has contributed to an increase in mortality of CKD patients. The onset of CVD often varies by time-of-day. Acute myocardial infarction or ventricular arrhythmia occurs most frequently d...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1486850
更新日期:2018-09-01 00:00:00
abstract::This study aimed to investigate the associations between individual difference factors (chronotype, Big Five, emotional competences) and perceived stress in French university students. In total, 362 students agreed to take part (Mage = 20.19 ± 1.75 years). Participants completed the Caen Chronotype Questionnaire, Big ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1752705
更新日期:2020-07-01 00:00:00
abstract::We assessed the impact of 12h fixed night shift (19:00-07:00h) work, followed by 36h of off-time, on the sleep-wake cycle, sleep duration, self-perceived sleep quality, and work-time alertness on a group composed of 5 registered and 15 practical nurses. Wrist actigraphy (Ambulatory Monitoring, Inc.), with data analysi...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120019341
更新日期:2003-03-01 00:00:00
abstract::The length of the free-running period (τ) affects how an animal re-entrains after phase shifts of the light-dark (LD) cycle. Those with shorter periods adapt faster to phase advances than those with longer periods, whereas those with longer periods adapt faster to phase delays than those with shorter periods. The free...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.700670
更新日期:2012-10-01 00:00:00
abstract::Twenty-two depressed subjects who met criteria for major depressive disorder were grouped according to their initial REM latency. Subjects with short (less than or equal to 60 min) initial REM latency were separated from those with normal (greater than 60 min) initial REM latency. Subjects with short initial REM laten...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529009056968
更新日期:1990-01-01 00:00:00
abstract::The appropriate time and place for sleep and waking are important factors for survival. Sleep and waking, rest and activity, flight and fight, feeding, and reproduction are all organized in relation to the day and night. A biological clock, the suprachiasmatic nucleus (SCN), synchronized by photic influences and other...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1080/07420520500545961
更新日期:2006-01-01 00:00:00
abstract::Using structural equation modeling, it can be shown that long weekly working hours and work on weekends, nights, and in shifts have detrimental effects on psychovegetative health. Employees' reported subjective work-life balance also decreases with increasing number of hours worked/week, days worked on weekends, or at...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2010.490099
更新日期:2010-07-01 00:00:00
abstract::In young healthy subjects salmon calcitonin (SCT), intranasally administered, increased in serum as a function of the drug administration time. The serum concentration of a 400 IU SCT dose monitored 10 min after dosing was statistically more significant when inhaled at 0000 than at other, more conventional, administra...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528809079555
更新日期:1988-01-01 00:00:00
abstract::Despite results linking shift work with ill health, only a few studies have addressed its relation with mortality. The purpose of the present study was to examine the hypothesis that shift work is a predictor of mortality. The study involved a sample of 22,411 individuals of the Swedish population. Data were obtained ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-200038520
更新日期:2004-01-01 00:00:00
abstract::Sleep disturbances, chronotype and social jetlag (SJL) have been associated with increased risks for major chronic diseases that take decades to develop, such as obesity, metabolic syndrome and cardiovascular disease. Potential relationships between poor sleep, chronotype and SJL as they relate to metabolic risk facto...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1563094
更新日期:2019-04-01 00:00:00
abstract::Various processes associated with mammalian reproduction exhibit circadian rhythms, yet no information is available concerning the presence of rhythmicity in meiosis-the crucial process of the production of sex cells. Following meiosis in cells derived from male mice exposed in vivo to daily light-dark cycles (LD), we...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529808998665
更新日期:1998-01-01 00:00:00
abstract::The aims of this study were to examine the genetic and environmental influences on diurnal preference and sleep quality, the association between these phenotypes, the genetic and environmental influences on this association, and the magnitude of overlap between these influences. Using a twin design, data on diurnal pr...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420521003663801
更新日期:2010-01-01 00:00:00
abstract::Freshwater crayfish have three known photoreceptive systems: the compound eyes, extraretinal brain photoreceptors, and caudal photoreceptors. The primary goal of the work described here was to explore the contribution of the brain photoreceptors to circadian locomotory activity and define some of the underlying neural...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420520903217960
更新日期:2009-08-01 00:00:00
abstract::A synopsis of the effects of exercise on the circadian system in nocturnal rodents is followed by a review of the few studies investigating the influence of exercise on the human circadian system. It is premature to make specific recommendations about using exercise to promote synchronization in people because of the ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529709001157
更新日期:1997-03-01 00:00:00
abstract::We ask if epidemiological studies into shift work and cancer may be prone to chronobiological errors. We illustrate how ignoring internal time (IT), or chronotype, may lead to what we call IT errors. Errors from truncating relevant external time (ET) information (activities start before and do not end with the shift) ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.877921
更新日期:2014-05-01 00:00:00
abstract::Although several studies of glia have examined glial fibrillary acid protein (GFAP) and its relationship to the circadian rhythms of different organisms, they have not explored the daily GFAP oscillations in the putative pacemakers of the crayfish Procambarus clarkii or in other crustaceans. In this study we investiga...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1071385
更新日期:2015-01-01 00:00:00
abstract::Recently, attention has been focused on the relationship among circadian typology, psychiatric symptoms, and personality traits. This study analyzes the influence of circadian typology on psychological distress, and the sensation-seeking personality trait. Five hundred seventeen college students (173 males), aged 17 t...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.790044
更新日期:2013-08-01 00:00:00
abstract::Field observations spanning 1 year of the visits of two bee species--Tetraglossula bigamica (Hymenoptera: Colletidae) and Pseudagapostemon brasiliensis (Hymenoptera: Halictidae)--to the flowers of Ludwigia elegans (Onagraceae) evinced the existence of circadian and circannual components in the rhythms of activity both...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529309064478
更新日期:1993-02-01 00:00:00
abstract::In mammals, non-visual responses to light involve intrinsically photosensitive melanopsin-expressing retinal ganglion cells (ipRGCs) that receive synaptic inputs from rod and cone photoreceptors. Several studies have shown that cones also play a role in light entrainment, photic responses of the suprachiasmatic nucleu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420521003695704
更新日期:2010-06-01 00:00:00
abstract::Twenty-one children aged 5-6 years (mean age: 71.2 months; S.D. = 2.7) were videotaped in 4 different kindergartens throughout the school day for a period of one week. Eighteen of these children were then followed up after the summer holidays and videotaped for one week while attending the first year of primary school...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528709078544
更新日期:1987-01-01 00:00:00
abstract::Fatigue is an increasingly noted factor in road accidents. The ability to predict and be aware of impairment in terms of driving capability is important for potential legal liability and road safety. However, to date, there have been few studies that have investigated the accuracy of individuals in predicting how safe...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520601083391
更新日期:2006-01-01 00:00:00
abstract::The aim of this study was to examine the impact of brief, unscheduled naps during work periods on alertness and vigilance in coastal pilots along the Great Barrier Reef. On certain routes, the duration of the work period can extend well beyond 24 h. Seventeen coastal pilots volunteered for the study, representing almo...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520802106819
更新日期:2008-04-01 00:00:00
abstract::The suprachiasmatic nucleus (SCN) of the hypothalamus is considered the master circadian oscillator in mammals. However, extra-SCN structures in the brain also display daily rhythms. Recently, we have demonstrated that the choroid plexus (CP) expresses core clock genes that are subjected to circadian regulation in a s...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1400978
更新日期:2018-02-01 00:00:00
abstract::The effect of varying the dose-delivery time within a 24 h period (12:12 light-dark cycle) on the immunomodulatory properties of corn oil administered by gavage to 120 B6C3F1 female mice was investigated. Mice, housed in six separate boxes equipped with timers to regulate light onset and offset (staggered by 4 h incre...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529909019085
更新日期:1999-03-01 00:00:00
abstract::Serious adverse cardiovascular events, including myocardial infarction, sudden cardiac death, and stroke, frequently result from rupture of atherosclerotic plaques with superimposed thrombosis and exhibit a pronounced circadian rhythmicity, peaking in the morning hours. Two potentially synergistic mechanisms play a pa...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-100001175
更新日期:2001-01-01 00:00:00
abstract::Previous studies have reported sex differences in the pathophysiology of hypertension and responses to blood pressure (BP)-lowering medications. Moreover, men exhibit typically higher BP than women, the differences being greater for systolic (SBP) than diastolic (DBP) BP. These differences become apparent during adole...
journal_title:Chronobiology international
pub_type: 杂志文章,随机对照试验
doi:10.3109/07420528.2012.701487
更新日期:2013-03-01 00:00:00
abstract::The circadian melatonin rhythm is highly reproducible and generally not easily altered. The few perturbations that are capable of significantly changing either the amplitude or the pattern of the 24-h melatonin rhythm are summarized herein. Aging alters cyclic melatonin production by decreasing the amplitude of the no...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529209064541
更新日期:1992-08-01 00:00:00
abstract::Julien-Joseph Virey (1775-1846) held the position of pharmacist-in-chief at the Val-de-Grâce, a military hospital. He was an innovative pharmacist, naturalist, anthropologist, and philosopher and a prolific author. His writings encompassed a wide range of topics, although many of his ideas were sometimes harshly quest...
journal_title:Chronobiology international
pub_type: 传,历史文章,杂志文章
doi:10.1081/cbi-100103184
更新日期:2001-03-01 00:00:00