Abstract:
:The effect of varying the dose-delivery time within a 24 h period (12:12 light-dark cycle) on the immunomodulatory properties of corn oil administered by gavage to 120 B6C3F1 female mice was investigated. Mice, housed in six separate boxes equipped with timers to regulate light onset and offset (staggered by 4 h increments), were treated for 5 consecutive days by intragastric (i.g.), administration of 5 mL/kg corn oil. Negative and positive control mice were given sham injections (needle inserted, but no injection). Sheep red blood cells (SRBCs) were injected intraperitoneally (i.p.) on the fifth day. Three days later, positive control mice were given cyclophosphamide intraperitoneally (80 mg/kg). Four days after SRBC injection, mice were weighed and killed, and spleens and thymuses were removed and weighed. Spleens were brought to single-cell suspensions and tested for an antibody response to the SRBC. Plaque-forming cells (PFCs), as measured per spleen, per 10(6) viable spleen cells or per 10(6) total spleen cells, exhibited significant circadian rhythms for mice given corn oil, but not for sham-gavage- and cyclophosphamide-treated mice. The peak response (acrophase, phi) occurred at 21 h, 22 h, and 23 h after lights on (HALO), respectively, with PFC values significantly different between the different time points. Corn oil and sham gavage affected the circadian pattern of antibody production; there was a high-amplitude (21-27%) rhythm observed when mice were treated with corn oil and no rhythm when mice received the sham-gavage treatment. In addition to testing mice near the end of the daily dark span and/or early light span to obtain a maximum immune response, this finding points to the importance of including as controls a group of animals that are not treated at all and a group given vehicle alone, rather than only sham-treated animals, for comparison with experimentally treated animals.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Ratajczak HV,Sothern RB,Dozier MM,Gaworski CLdoi
10.3109/07420529909019085subject
Has Abstractpub_date
1999-03-01 00:00:00pages
185-97issue
2eissn
0742-0528issn
1525-6073journal_volume
16pub_type
杂志文章abstract::Earlier we reported that in a number of experiments pineal melatonin production in rats under constant laboratory conditions displayed seasonal rhythms but subsequently were not always able to confirm this. Since there was no indication under which conditions such rhythms may be present, we performed four consecutive ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.719958
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abstract::Thirty-six undergraduate subjects were divided into 'larks' and 'owls' by median split using the morningness test devised by Horne and Ostberg. Each was given a battery of two performance tests at six times of day, in a design that counter-balanced for practice effects. Oral temperatures were also recorded. Slight (1 ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528609066364
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abstract::Intense artificial light can phase-shift circadian rhythms and improve performance, sleep, and well-being during shiftwork simulations. In real shiftworkers, however, exposure to sunlight and other time cues may decrease the efficacy of light treatment, and occupational and family responsibilities may make it impracti...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529509064509
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abstract:OBJECTIVE:Morning stiffness and plasma cytokine levels in rheumatoid arthritis (RA) patients exhibit 24-hour variations. Tumor necrosis factor-α (TNF-α) plays a central role in RA clinical conditions, including the invasion of inflammatory cells, destruction of cartilage, systemic inflammatory response and its levels s...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.878350
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abstract::Although daily rhythms regulate multiple aspects of human physiology, rhythmic control of the metabolome remains poorly understood. The primary objective of this proof-of-concept study was identification of metabolites in human plasma that exhibit significant 24-h variation. This was assessed via an untargeted metabol...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.699122
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abstract::The circadian clock of man and mammals shows a hierarchic organization. The master clock, located in the suprachiasmatic nuclei (SCN), controls peripheral oscillators distributed throughout the body. Rhythm generation depends on molecular clockworks based on transcriptional/translational interaction of clock genes. Nu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.949735
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abstract::In Channa punctatus, a significant daily variation in hypothalamic 5-HT level and monoamine oxidase (MAO) activity was noticed in preparatory phase (February), but not in prespawning (May) or postspawning (November) phases. Hypothalamic dopamine (DA) and noradrenaline (NA), on the other hand, showed marked daily varia...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528809067776
更新日期:1988-01-01 00:00:00
abstract::Two different medications, one assumed to be a tranquilizer and the other an antifatigue agent, were tested. Both were found to be ineffective and thus were viewed as placebos and named P1 and P2. The effect of P1 and P2 on the circadian rhythms of a set of variables (e.g., sleep/wake, oral temperature and grip streng...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-02-01 00:00:00
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journal_title:Chronobiology international
pub_type: 杂志文章
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journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529808993198
更新日期:1998-11-01 00:00:00
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journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701420725
更新日期:2007-01-01 00:00:00
abstract::Chronic sympathetic denervation of the pineal gland by bilateral removal of the superior cervical ganglia (SCG) was performed on female rats 30 days before impregnation. The offspring, maintained in the dark from birth, had disruption of the malate dehydrogenase circadian rhythm in the testes at 25 days of age. A dail...
journal_title:Chronobiology international
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journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1080/07420528709078511
更新日期:1987-01-01 00:00:00
abstract::The phase and period responses to short light pulses were studied in the jerboa, a seasonal, hibernating, nocturnal rodent from the Atlas region in Morocco. The jerboa, which is a saltatory species, showed precise activity onsets and offsets under a light-dark (LD) cycle using infrared captors to record locomotor acti...
journal_title:Chronobiology international
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doi:10.3109/07420528.2010.504315
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journal_title:Chronobiology international
pub_type: 杂志文章
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journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528709078520
更新日期:1987-01-01 00:00:00
abstract::The circadian clock regulates many cellular processes, notably including the cell cycle, metabolism and aging. Mitochondria play essential roles in metabolism and are the major sites of reactive oxygen species (ROS) production in the cell. The clock regulates mitochondrial functions by driving daily changes in NAD(+) ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1085388
更新日期:2015-01-01 00:00:00
abstract::It has long been recognized that older shift workers may have shorter and more disturbed day sleeps between successive night shifts than their younger colleagues. This has given rise to considerable concern over the safety of aging shift workers because of the increasing age of the work force and increases in retireme...
journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
pub_type: 杂志文章
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journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100107518
更新日期:2001-09-01 00:00:00
abstract::In amphibians, voltage-gated sodium (Nav) channels in cone ON bipolar cells (ON-CBC) amplify cone signals in the dark and in mesopic background light. However, during light adaptation, dopamine, acting through D1 receptors (D1R), suppresses Nav channels and therefore act as a gain control mechanism. Curiously in roden...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.951054
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abstract::Circadian rhythms in plants are liable to masking, i.e. alterations by environmental influencing agents. Experiments have been reported for both positive and negative masking, attributed to a Zeitgeber which may either increase or decrease the amplitude of a circadian rhythm (CR). In some instances, the CR may even be...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528909059138
更新日期:1989-01-01 00:00:00
abstract::The degu (Octodon degus) is a diurnal rodent, although phase inversions to nocturnal behavior have been reported under specific laboratory conditions. The reliability of this animal as a diurnal model of sleep therefore requires further characterization of intrinsic circadian pacemaker properties. A phase response cur...
journal_title:Chronobiology international
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
abstract::The 10 min psychomotor vigilance task (PVT) is commonly used in laboratory studies to assess the impact of sleep loss, sustained wakefulness, and/or time of day on neurobehavioral performance. In field settings, though, it may be impractical for participants to perform a test of this length. The aim of this study was ...
journal_title:Chronobiology international
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abstract::We analyzed the association between change in work schedule and modifications in nutritional status. We performed a panel study with nursing professionals based on two surveys seven year apart (n = 372). Groups with no change in work schedule, change from daytime to night shift, and change from night to daytime shift ...
journal_title:Chronobiology international
pub_type: 杂志文章
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abstract::The aim of this study was to examine the effect of the interaction of circamensal and diurnal rhythms in temperature upon the production of maximal voluntary muscle force. Ten eumenorrheic females (mean age: 24 +/- 3 yr mean body mass: 58.4 +/- 6.9 kg) participated in the experiment at both 06:00 and 18:00h at the mid...
journal_title:Chronobiology international
pub_type: 杂志文章
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