Abstract:
:High fat diet (HFD) consumption alters the synchronized circadian timing system resulting in harmful loss, gain or shift of transcriptional oscillations. The aryl hydrocarbon receptor (AhR) shares structural homology to clock genes, containing both PAS domains and basic helix-loop helix structural motifs, allowing for interaction with components of the primary circadian feedback loop. Activation of AhR alters circadian rhythmicity, primarily through inhibition of Clock/Bmal1-mediated regulation of Per1. AhR-deficient mice are protected from diet-induced metabolic dysfunction, exhibiting enhanced insulin sensitivity and glucose tolerance. This study examined whether AhR haploinsufficiency can also protect against diet-induced alterations in rhythm. After feeding AhR+/+ and AhR+/- mice an HFD (60% fat) for 15 weeks, samples were collected every 4 hours over a 24-hour period. HFD altered the rhythm of serum glucose and the metabolic transcriptome, including hepatic nuclear receptors Rev-erbα and PPARγ in wild-type c57bl6/j mice. AhR reduction provided protection against diet-induced transcriptional oscillation changes; serum glucose and metabolic gene rhythms were protected from the disruption caused by HFD feeding. These data highlight the critical role of AhR signaling in the regulation of metabolism and provide a potential therapeutic target for diseases characterized by rhythmic desynchrony.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Jaeger C,Xu C,Sun M,Krager S,Tischkau SAdoi
10.1080/07420528.2016.1256298subject
Has Abstractpub_date
2017-01-01 00:00:00pages
318-336issue
3eissn
0742-0528issn
1525-6073journal_volume
34pub_type
杂志文章abstract::Light is an important environmental stimulus for the entrainment of the circadian clock and for increasing alertness. The intrinsically photosensitive ganglion cells in the retina play an important role in transferring this light information to the circadian system and they are elicited in particular by short-waveleng...
journal_title:Chronobiology international
pub_type: 杂志文章,随机对照试验
doi:10.3109/07420528.2014.893242
更新日期:2014-06-01 00:00:00
abstract::Fourteen ambulatory subjects, varying in their amount of habitual physical activity, were studied for 24 h during a total of 25 "typical" days. Rectal temperature was recorded every 6 minutes, an activity diary was filled in every half hour, and wrist activity and heart rate were monitored every minute. Actimetry and ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529908998721
更新日期:1999-07-01 00:00:00
abstract::In Cushing's syndrome, the cortisol rhythm is impaired and can be associated with the disruption in the rhythmic expression of clock genes. In this study, we evaluated the expression of CLOCK, BMAL1, CRY1, CRY2, PER1, PER2, PER3 genes in peripheral blood leukocytes of healthy individuals (n = 13) and Cushing's disease...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1758126
更新日期:2020-06-01 00:00:00
abstract::During a 7-10 day span, circadian rhythms of sleep-wake, self-rated fatigue and mood, oral temperature, eye-hand skill and right and left hand grip strength were investigated in eight subjects: five males (21-28 years of age), members of the French sabre fencing team selected for the 1984 Olympic Games in Los Angeles,...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528509055559
更新日期:1985-01-01 00:00:00
abstract::A number of Djungarian hamsters (Phodopus sungorus) of our institute show activity patterns that seem incompatible with proper adjustment to a periodic environment. The activity onset of those animals is continuously delayed, whereas the activity offset is stably coupled to "lights-on", leading to compression of activ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420520903398583
更新日期:2010-01-01 00:00:00
abstract::In 33 patients with heart failure (NYHA II-III), the 24-h blood pressure rhythm was examined before and after the titration period of two ACE inhibitors. Blood pressure was measured by the oscillometric method using the blood pressure monitor 90202 from SpaceLabs, Inc. The measurements were taken from 06:00 to 22:00 h...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07420529109059177
更新日期:1991-01-01 00:00:00
abstract::We assessed the impact of 12h fixed night shift (19:00-07:00h) work, followed by 36h of off-time, on the sleep-wake cycle, sleep duration, self-perceived sleep quality, and work-time alertness on a group composed of 5 registered and 15 practical nurses. Wrist actigraphy (Ambulatory Monitoring, Inc.), with data analysi...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120019341
更新日期:2003-03-01 00:00:00
abstract::In 24h studies of bone marrow (BM), circadian stage-dependent variations were demonstrated in the proliferative activity of BM cells from subsets of 35 healthy diurnally active men. On an average, the percentage of total BM cells in deoxyribonucleic acid (DNA) synthesis phase was 188% greater at midday than at midnigh...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-120002594
更新日期:2002-01-01 00:00:00
abstract::The length of the free-running period (τ) affects how an animal re-entrains after phase shifts of the light-dark (LD) cycle. Those with shorter periods adapt faster to phase advances than those with longer periods, whereas those with longer periods adapt faster to phase delays than those with shorter periods. The free...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.700670
更新日期:2012-10-01 00:00:00
abstract::Humans may be subject to seasonal variations, as evidenced by the existence of seasonal affective disorder (SAD) and midwinter insomnia. However, some recent studies have shown that the seasonal variation in the phase of the circadian rhythm is relatively weak in healthy humans. In the present study, evidence is found...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529808993198
更新日期:1998-11-01 00:00:00
abstract::The organizing committee of the 2016 Rio Olympic Games recently announced that some of the preliminary and final competitions will be held at night. The present article discusses the potential harmful effects of these late-night competitions on sleep, circadian rhythms and athletic performance during the Olympic Games...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2016.1150290
更新日期:2016-01-01 00:00:00
abstract::Besides degrading vigilant attention, total sleep deprivation (TSD) impairs reversal learning performance and blunts affective reactions to feedback. Whether these effects are downstream consequences of information acquisition failures from degraded vigilant attention, or distinct from degraded vigilant attention, is ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1819306
更新日期:2020-09-22 00:00:00
abstract::Multiple components of the circadian central clock are phosphoproteins, and it has become increasingly clear that posttranslational modification is an important regulator of circadian rhythm in diverse organisms, from dinoflagellates to humans. Genetic studies in Drosophila have identified double-time (dbt), a serine/...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-100103963
更新日期:2001-05-01 00:00:00
abstract::Recent studies of shift-working women have reported that excessive exposure to light at night (LAN) may be a risk factor for breast cancer. However, no studies have yet attempted to examine the co-distribution of LAN and breast cancer incidence on a population level with the goal to assess the coherence of these earli...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520801921572
更新日期:2008-02-01 00:00:00
abstract::Shiftwork, particularly that including night work, causes disruption of biological rhythms and perturbation of the social and family life that can negatively affect performance efficiency, health, and social relations. Adverse effects can manifest themselves in the short term as sleep disturbances, shiftlag syndrome, ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529709001147
更新日期:1997-03-01 00:00:00
abstract::Career decisions are based on the fit between an individual and his/her environment. This study explores the effect of person-environment fit regarding actual and preferred weekly working hours on early and late retirement intentions in a sample of 7,859 employees aged 50 to 65 years of age living in Germany. Findings...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1806291
更新日期:2020-08-24 00:00:00
abstract::Sleep and fatigue-associated symptoms are prominent during chemotherapy. The purpose of this pilot study was to examine bright light effects on sleep disruption, fatigue, daytime sleepiness, depression, and quality of life (QOL) in women with stage I-III breast cancer undergoing chemotherapy. In this 2-group randomize...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2021.1871914
更新日期:2021-01-21 00:00:00
abstract::Changes in rectal temperature during mild exercise in the middle of the rising (11:00 h) and falling (23:00 h) phases of the circadian rhythm of resting core temperature have been compared. Seven healthy males were studied at rest, while exercising on a cycle ergometer (60 min at 80 W), and during the first 30 min of ...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章
doi:10.1080/07420520601142551
更新日期:2007-01-01 00:00:00
abstract::The properties of the circadian photoperiodic oscillator have been investigated in detail only in the Japanese quail. While the study of the quail is clearly very important, one cannot simply assume that other species, especially passerines that seem to have a different circadian organization than quail, function the ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120014570
更新日期:2002-09-01 00:00:00
abstract::Corticosterone levels were determined in the 7-week-old male rat maintained under different feeding and lighting schedules. At 4 weeks of age, the animals were kept either under a natural photoperiod (LD) or were subjected to continuous illumination (LL). Access to food was either ad libitum or restricted to an 8 hr s...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528409063909
更新日期:1984-01-01 00:00:00
abstract::Circadian phase dependency in pharmacokinetics and hemodynamic effects on blood pressure and heart rate of different galenic formulations of nifedipine (immediate-release, sustained-release, and i.v. solution) were studied in healthy subjects or in hypertensive patients. Pharmacokinetics of immediate-release but not s...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529109059184
更新日期:1991-01-01 00:00:00
abstract::The effect of stocking density on the locomotor activity of African catfish C. gariepinus under different light regimes was investigated. C. gariepinus were stocked under different densities (1, 5, or 10 fish/tank), and their locomotor activity recorded under light-dark (LD), constant light (LL), constant darkness (DD...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.606388
更新日期:2011-11-01 00:00:00
abstract::It has long been recognized that older shift workers may have shorter and more disturbed day sleeps between successive night shifts than their younger colleagues. This has given rise to considerable concern over the safety of aging shift workers because of the increasing age of the work force and increases in retireme...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1080/07420520802106694
更新日期:2008-04-01 00:00:00
abstract::The suprachiasmatic nucleus (SCN) of the hypothalamus is considered the master circadian oscillator in mammals. However, extra-SCN structures in the brain also display daily rhythms. Recently, we have demonstrated that the choroid plexus (CP) expresses core clock genes that are subjected to circadian regulation in a s...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1400978
更新日期:2018-02-01 00:00:00
abstract::Ninety-five nonresident girls of a private school volunteered for the study with the teachers' help as well as parental consent. Ages were approximately 8, 9, and 10 years. They were synchronized with diurnal activity from 0730 to 2100 h and nocturnal rest. Fatigue, drowsiness, and attention were self-rated using visu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529109059164
更新日期:1991-01-01 00:00:00
abstract::Data on sleep or circadian abnormalities and metabolic disturbances in euthymic bipolar disorders are scarce and based on small sample sizes. The aim of this study was to explore the associations between sleep disturbances, chronotype and metabolic components in a large sample of euthymic patients with bipolar disorde...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1332071
更新日期:2017-01-01 00:00:00
abstract::Recent studies suggest melatonin, due to its antioxidant and free-radical-scavenging actions, may play a role in the neuroprotection against amyloid, which is implicated in the pathogenesis of Alzheimer's disease (AD). In this study, we determined urinary 6-sulfatoxymelatonin (aMT6s) excretion together with actigraphi...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100103973
更新日期:2001-05-01 00:00:00
abstract::Few studies have focused on the influence of circadian typology on drug use, and none has considered the use of illegal drugs and hazardous alcohol consumption. This study analyzes the influence of circadian typology on several types of drug consumption (habitual or sporadic), hangover symptoms (past 12 mos), and, mor...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.553018
更新日期:2011-04-01 00:00:00
abstract::The aim of this study was to examine the sleep strategies used in breaks between consecutive shifts. For two weeks, 253 shiftworkers collected data regarding the timing of all shifts and sleeps. The final dataset included 395 between-shift breaks that had a standard duration (i.e. ~16 h). If a break included an entire...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2016.1167716
更新日期:2016-01-01 00:00:00
abstract::In order to optimize chronotherapeutic schedules (designs), we examined the interindividual differences in chronopharmacologic effects of drugs with consideration of the following three factors: (a) inherited factors of direct relevance to chronopharmacology (genetic variability, gender-related differences) as well as...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529309059721
更新日期:1993-12-01 00:00:00