Abstract:
:Sleep and fatigue-associated symptoms are prominent during chemotherapy. The purpose of this pilot study was to examine bright light effects on sleep disruption, fatigue, daytime sleepiness, depression, and quality of life (QOL) in women with stage I-III breast cancer undergoing chemotherapy. In this 2-group randomized controlled trial (NCT02658708), participants were randomized to receive either blue-green light of 12,000 lux (experimental) or dim red light of 5 lux (control). Light therapy was self-administered using a light visor cap at home. Both groups received 30-minute daily light therapy for 21 consecutive days following the 2nd cycle of chemotherapy. Sleep quality, fatigue, daytime sleepiness, depression, and QOL were self-reported, and nocturnal sleep was monitored by ambulatory polysomnography before the initiation of chemotherapy (baseline) and following the light intervention (posttest). Relative change was assessed at posttest controlling for pretest scores. At posttest, the experimental group self-reported significantly shorter sleep latency than controls (10 vs. 20 min, p = .045) consistent with polysomnography findings (14 vs. 63 min). Polysomnography also revealed longer total sleep time (467 vs. 315 min) and higher sleep efficiency (74% vs. 58%) in experimental vs. controls. Participants receiving bright light experienced a 30% relative decrease in depression, while there was a 24% increase in the controls. The experimental group reported substantially fewer increases in symptom intensity than controls (33% vs. 166%). These findings suggest that bright light likely improved sleep quality and depression and mitigated worsening intensity of symptoms during the first three cycles of chemotherapy. However, features of bright light, e.g., treatment duration, frequency, and timing in relation to chemotherapy treatment require further investigation.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Wu HS,Davis JE,Chen Ldoi
10.1080/07420528.2021.1871914subject
Has Abstractpub_date
2021-01-21 00:00:00pages
1-11eissn
0742-0528issn
1525-6073pub_type
杂志文章abstract::The effect of varying the dose-delivery time within a 24 h period (12:12 light-dark cycle) on the immunomodulatory properties of corn oil administered by gavage to 120 B6C3F1 female mice was investigated. Mice, housed in six separate boxes equipped with timers to regulate light onset and offset (staggered by 4 h incre...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529909019085
更新日期:1999-03-01 00:00:00
abstract::The prevalence of delayed sleep phase syndrome (DSPS) has been estimated to be quite low. Although no genetic inheritance pattern has been described, it has been reported that close to 50% of DSPS patients have biological relatives with similar symptoms. A pedigree of one extended family with symptoms suggestive of DS...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100107518
更新日期:2001-09-01 00:00:00
abstract::The specific circadian role proposed for endogenous melatonin production was based on a study of sighted people who took low pharmacological doses (500 microg) of this chemical signal for the "biological night": the magnitude and direction of the induced phase shifts were dependent on what time of day exogenous melato...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520500398064
更新日期:2005-01-01 00:00:00
abstract::Recently, attention has been focused on the relationship among circadian typology, psychiatric symptoms, and personality traits. This study analyzes the influence of circadian typology on psychological distress, and the sensation-seeking personality trait. Five hundred seventeen college students (173 males), aged 17 t...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.790044
更新日期:2013-08-01 00:00:00
abstract::The circadian clock regulates many cellular processes, notably including the cell cycle, metabolism and aging. Mitochondria play essential roles in metabolism and are the major sites of reactive oxygen species (ROS) production in the cell. The clock regulates mitochondrial functions by driving daily changes in NAD(+) ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1085388
更新日期:2015-01-01 00:00:00
abstract::Intense artificial light can phase-shift circadian rhythms and improve performance, sleep, and well-being during shiftwork simulations. In real shiftworkers, however, exposure to sunlight and other time cues may decrease the efficacy of light treatment, and occupational and family responsibilities may make it impracti...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529509064509
更新日期:1995-04-01 00:00:00
abstract::The importance of circadian clocks in the regulation of adult physiology in mammals is well established. In contrast, the ontogenesis of the circadian system and its role in embryonic development are still poorly understood. Although there is experimental evidence that the clock machinery is present prior to birth, da...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.986576
更新日期:2015-04-01 00:00:00
abstract::Besides degrading vigilant attention, total sleep deprivation (TSD) impairs reversal learning performance and blunts affective reactions to feedback. Whether these effects are downstream consequences of information acquisition failures from degraded vigilant attention, or distinct from degraded vigilant attention, is ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1819306
更新日期:2020-09-22 00:00:00
abstract::The human sleep-wake cycle is characterized by significant individual differences. Those differences in the sleep-wake cycle are partially heritable but are also influenced by environmental factors like the light/dark cycle or social habits. In this study we analyse for the first time the sleep-wake rhythm of adolesce...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.741173
更新日期:2012-12-01 00:00:00
abstract::Social anxiety has recently been linked to morningness-eveningness; however, the psychological mechanisms underlying this relationship are not well known. As such, the purpose of the current study is to propose a model by which morningness-eveningness is related to social anxiety symptoms through punishment sensitivit...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1529679
更新日期:2019-02-01 00:00:00
abstract::The first aim of the study was to assess clock-time patterning of work-related injuries (WRIs) of firemen (FM) of Saône et Loire-71 (France) during the 4-yr span of 1 January 2004 to 31 December 2007. FM of this service are legally required to log every WRI and seek its evaluation by the medical service, whether the W...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.603170
更新日期:2011-10-01 00:00:00
abstract::A physiological dose of orally administered melatonin shifts circadian rhythms in humans according to a phase-response curve (PRC) that is nearly opposite in phase with the PRCs for light exposure: melatonin delays circadian rhythms when administered in the morning and advances them when administered in the afternoon ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529209064550
更新日期:1992-10-01 00:00:00
abstract::Previous literature suggests that human behaviour and physiology are somehow altered by the moon-cycle, with particular emphasis on poorer sleep quality and increased aggressive behaviour during full moon. The latter variables can negatively impact athletes' recovery and increase the likelihood of injury resulting fro...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1483943
更新日期:2018-09-01 00:00:00
abstract::Shift workers are known to have an increased risk of developing cardiovascular disease (CVD) compared with day workers. An important factor contributing to this increased risk could be the increased incidence of postprandial metabolic risk factors for CVD among shift workers, as a consequence of the maladaptation of e...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1081/cbi-200037171
更新日期:2004-01-01 00:00:00
abstract::A synopsis of the effects of exercise on the circadian system in nocturnal rodents is followed by a review of the few studies investigating the influence of exercise on the human circadian system. It is premature to make specific recommendations about using exercise to promote synchronization in people because of the ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529709001157
更新日期:1997-03-01 00:00:00
abstract::Circadian rhythms in mammals are driven by a central clock in the suprachiasmatic nucleus (SCN). In vitro, temperature cycles within the physiological range can act as potent entraining cues for biological clocks. We altered the body temperature (Tc) rhythm in rats by manipulating energy intake (EI) to determine wheth...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1112395
更新日期:2016-01-01 00:00:00
abstract::Visual sensitivity rhythm has been assessed by several authors in animals. It shows an intrinsic circadian rhythm of some retinal mechanisms that could account for fluctuating sensitivity to light during the day in these species. However, very little is known concerning a possible circadian rhythm of visual sensitivit...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529709040540
更新日期:1997-01-01 00:00:00
abstract::Multiple components of the circadian central clock are phosphoproteins, and it has become increasingly clear that posttranslational modification is an important regulator of circadian rhythm in diverse organisms, from dinoflagellates to humans. Genetic studies in Drosophila have identified double-time (dbt), a serine/...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-100103963
更新日期:2001-05-01 00:00:00
abstract::Diurnal and seasonal rhythms of cortisol, testosterone, and DHEA were examined, as little is known about the relationship between these rhythmicities and pubertal development. Salivary samples were obtained from 60 boys and 60 girls at approximately 07:45, 08:00, 08:30, 12:00, 16:50, and 21:00 h. The participants' age...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701649471
更新日期:2007-01-01 00:00:00
abstract::Circadian rhythmicity of the structural morphometric model of rat endocrine pancreas has been studied in 24 Wistar female rats, four months old, kept in LD 12:12. The following parameters were evaluated: the volume fractions of nucleus and cytoplasm of exocrine cells, the size distribution and number in unit tissue vo...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529009059148
更新日期:1990-01-01 00:00:00
abstract::In young healthy subjects salmon calcitonin (SCT), intranasally administered, increased in serum as a function of the drug administration time. The serum concentration of a 400 IU SCT dose monitored 10 min after dosing was statistically more significant when inhaled at 0000 than at other, more conventional, administra...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528809079555
更新日期:1988-01-01 00:00:00
abstract::In previous research, it was determined that the altitude of origin altered the parameters of photic entrainment and free-running rhythmicity of adult locomotor activity of the high-altitude Himalayan (haH) strain (Hemkund-Sahib, 4121 m above sea level) of Drosophila helvetica compared to the low-altitude Himalayan (l...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701649448
更新日期:2007-01-01 00:00:00
abstract::The objectives of the study were to investigate the associations between night work and disability pension (DP) due to all causes, cardiovascular (CVD), mental, and other diagnoses, adjusting for familial confounding. The material of the study included comprehensive survey data on 27 165 Swedish twins born in 1935-195...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1399137
更新日期:2018-02-01 00:00:00
abstract::Several substances change the period length of the circadian oscillator in the laminar pulvinus of Phaseolus coccineus L. if offered continuously via the transpiration stream to the isolated leaves in continuous light and constant temperature. The osmotica mannitol and PEG 6000 (polyethylene glycol) lengthen the circa...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528509055537
更新日期:1985-01-01 00:00:00
abstract::The influence of environmental (extracellular) pH on the sporulation rhythm in Neurospora crassa was investigated for wild-type (frq+) and the mutants chr, frq1, frq7, and frq8. In all mutants, including wild type, the growth rate was found to be influenced strongly by extracellular pH in the range 4-9. On the other h...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100102109
更新日期:2000-11-01 00:00:00
abstract::Correlation between systolic (SBP) and diastolic (DBP) blood pressure (BP) level and target organ damage, cardiovascular disease (CVD) risk, and long-term prognosis is much greater for ambulatory BP monitoring (ABPM) than daytime office measurements. The 2013 ABPM guidelines specified herein are based on ABPM patient ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.750490
更新日期:2013-04-01 00:00:00
abstract::Eight diurnally active (approximately 0730-1100 hr) adults (41-61 yr) suffering from nocturnal asthma volunteered for a double-blind, cross-over randomized study of a once-daily dosing (600-900 mg/24 hr) of Armophylline (Rorer s.a., France), a sustained-release theophylline given either at 0800 hr or 2000 hr for 8-day...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07420528709083530
更新日期:1987-01-01 00:00:00
abstract::The circadian system is organized in a hierarchy of multiple oscillators, with the suprachiasmatic nucleus (SCN) as the master oscillator in mammals. The SCN is formed by a group of coupled cell oscillators. Knowledge of this coupling mechanism is essential to understanding entrainment and the expression of circadian ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1380658
更新日期:2018-01-01 00:00:00
abstract::In two experiments, triazolam (2.5 and 1.5 mg/animal) failed to significantly enhance the rate of reentrainment of hamsters (Mesocricetus auratus) to an 8-hr advance of their light-dark cycle. Evidently the phase-shifting effects of triazolam are not robust. The animals did not run much in their wheels in response to ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529009056952
更新日期:1990-01-01 00:00:00
abstract::The pharmacokinetics of naproxen was studied in 12 healthy male volunteers after a single oral dose of 500 mg at 10:00 and 22:00 h. Ingestion of drug at 22:00 h delayed the occurrence of peak serum levels (p < 0.0212). None of the other pharmacokinetic parameters exhibited any significant diurnal variations. ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529309059703
更新日期:1993-04-01 00:00:00